First-passage dynamics of obstructed tracer particle diffusion in one-dimensional systems

The standard setup for single-file diffusion is diffusing particles in one dimension which cannot overtake each other, where the dynamics of a tracer (tagged) particle is of main interest. In this article we generalise this system and investigate first-passage properties of a tracer particle when flanked by crowder particles which may, besides diffuse, unbind (rebind) from (to) the one-dimensional lattice with rates $k_{\rm off}$ ($k_{\rm on}$). The tracer particle is restricted to diffuse with rate $k_D$ on the lattice. Such a model is relevant for the understanding of gene regulation where regulatory proteins are searching for specific binding sites ona crowded DNA. We quantify the first-passage time distribution, $f(t)$ ($t$ is time), numerically using the Gillespie algorithm, and estimate it analytically. In terms of our key parameter, the unbinding rate $k_{\rm off}$, we study the bridging of two known regimes: (i) when unbinding is frequent the particles may effectively pass each other and we recover the standard single particle result $f(t)\sim t^{-3/2}$ with a renormalized diffusion constant, (ii) when unbinding is rare we recover well-known single-file diffusion result $f(t)\sim t^{-7/4}$. The intermediate cases display rich dynamics, with the characteristic $f(t)$-peak and the long-time power-law slope both being sensitive to $k_{\rm off}$

Мечети региона Заказанье в трактате Ш. Марджани «Мустафад ал-Ахбар фи Ахвали Казан ва Булгар»

The article introduces the content, structure, and features of one of the chapters of historical treatise of Shihabaddin Mardjani “Mustafad al-Akhbar fi Ahvali Kazan wa Bulgar”. In this Chapter, the author described the history of the most important Tatar mosques located in the historical and cultural region of Qazan Arty, as well as in the extreme geographical points of the chosen area. In addition, the author left valuable biographical information about the imams who served in these mosques. Understanding of this material allowed us to establish the prerequisites for the formation of Sh. Mardjani as a historian and probable reasons that prompted him to turn to the historical and local history topics. In addition, the significance of studied layer of scientist’s heritage for the culture of Tatar people, Tatar historiography, Islamic studies, local history and genealogy is shown. The article is accompanied by illustrative material.Статья знакомит ссодержанием, структурой иособенностями одной из глав исторического трактата Шихабаддина Марджани «Мустафад ал-ахбар фи Ахвали Казан ва Булгар». В рассматриваемой главе автор изложил историю наиболее значимых татарских мечетей, расположенных в историко-культурном регионе Заказанье, а также в крайних географических точках выбранного им ареала. Кроме этого, автор оставил ценные биографические сведения о служивших в мечетях имамах. Осмысление данного материала позволило установить предпосылки становления Ш. Марджани как ученого-историка и вероятные причины, побудившие его обратиться к историко-краеведческой тематике. Кроме этого, показывается значимость исследованного пласта наследия ученого для культуры татарского народа, татарской историографии, исламоведения, краеведения и генеалогии. Статья сопровождается иллюстративным материалом

The revival of a Russian village : a case study

Statistical indicators and economic markers demonstrate objectively the difficult situation faced by contemporary Russian village. Old ways of life are irretrievably lost, new market mechanisms are still requiring some refinement. It is necessary to make some adjustments to the formulation and implementation of agricultural development programs. In addition to other priority tasks of this area, special attention should be paid to the problem of staff shortage in rural areas. This problem requires a detailed, comprehensive consideration (continuity recovery university – enterprise, practical knowledge multiplication share, the work prestige increase in rural areas, etc. - in an integrated approach). The Naberezhnye Chelny Institute CFI scientists project "School for farmer managers" which involves a feasible relief action in advice (legal and economic) in the formation and development of farms, in the development and testing of models of effective entrepreneurship land and in the creation of comfortable information environment for participants is aimed on personnel issues and problem acuity ease.peer-reviewe

Information competence development on the basis of professional-oriented video materials

The article deals with the challenges of the development of university students’ information competence in the process of foreign language teaching. It discusses the potential of foreign languages in the professional-oriented training. Interrelation of critical thinking, communication skills and the level of information competence development is observed. The dynamics of the indicators of its development is investigated. The results of the experiment give reasons to conclude that the dynamics of students’ information competence formation are directly dependent on their ability to work with facts in a proper way, grasping necessary details, considering different approaches to professional problem, dealing with controversial issues, interpreting the information adequately, using and expressing the acquired knowledge appropriately.peer-reviewe

Subject-object orientations for students with different learning profiles

The relevance of the research problem due to the necessity of studying the psychology of students as a period of intense development of personal and activity-related characteristics among which there are basic life orientation of a person as a subject of own life to account for them in educational process. The purpose of this article is to identify the specifics of the subject-object orientations for students concerning general personal and professional orientation of a person trained for different profiles. The leading method to study this problem is the original questionnaire of the subject-object orientations in accordance with their structure allowing to identify the priority development of certain components of the subject-object orientations reflecting the creative or adaptive orientation of life and the high life or low locus of control. The findings suggest significant differences in the subject-object orientations of students carried out different career choices and ultimately a way of life. Students – future psychologists differ moderately expressed subjectivity, creative direction to internal and external world, decreases as the learning; students – future artists are characterized by bright creative direction; students ‒ the future military doctors are characterized by less bright subjectiveness and distinct adaptive orientation. The article can be useful in the process of training and education of students of different profile as well as in the development of training programs of different specialties.peer-reviewe

Генетический паспорт больного псориазом

The article systematizes information about genetic polymorphisms associated with the risk of psoriasis and psoriatic arthritis development. Gene variants that are potentially essential for their inclusion in genetic tests were sampled taking into consideration polymorphism localization. The presented data are sufficient to prepare the genetic profile of psoriatic patients, forecast the clinical course of the disease and potential efficacy of treatment, and calculate the risk of the disease development in the patients relatives.В статье систематизированы сведения о генных полиморфизмах, ассоциированных с риском развития псориаза и псориатического артрита. Проведен отбор вариантов генов, потенциально значимых для включения их в генетические тесты, с учетом локализации полиморфизмов. Представленные данные позволяют составить «генетический паспорт» больного псориазом, прогнозировать клиническое течение болезни, возможную эффективность терапии, рассчитать риск развития заболевания у родственников пациента

Особенности терапии больных псориазом с метаболическим синдромом

The article provides information on the prevalence of metabolic syndrome in patients with psoriasis. The criteria for the diagnosis of metabolic syndrome are presented. The General mechanisms of inflam - mation development in psoriasis and diseases forming the metabolic syndrome are described. Systemic subclinical inflammatory process developing in psoriasis and metabolic syndrome is considered as the main pathogenetic mechanism of their mutual negative influence. The difficulties of treatment of patients with psoriasis with metabolic syndrome are largely associated with the choice of a safe and effective method of treatment. The description of the drug apremilast (OTEZLA®) is a selective inhibitor of the enzyme phosphodiesterase 4, which may be the best drug in the therapy of patients with psoriasis and metabolic syndrome.В статье приведены сведения о распространенности метаболического синдрома у больных псориазом. Представлены критерии диагностики метаболического синдрома. Описаны общие механизмы развития воспаления при псориазе и заболеваниях, формирующих метаболический синдром. Системный субклинический воспалительный процесс, развивающийся при псориазе и метаболическом синдроме, рассматривается как основной патогенетический механизм их взаимного негативного влияния. Трудности терапии больных псориазом с метаболическим синдромом во многом связаны с выбором безопасного и эффективного метода лечения. Приведено описание препарата апремиласта (ОТЕСЛА®) — селективного ингибитора фермента фософодиэстеразы 4, который может быть оптимальным лекарственным средством в терапии пациентов с псориазом и сопутствующим метаболическим синдромом

Asymmetry of pholidosis bilateral traits in sand lizard (Lacerta agilis, Reptilia, Squamata) from the Republic of Tatarstan

Such deviations as asymmetry and abnormalities can occur because of some external and internal factors that affect the organism during embryogenesis. The asymmetry of bilateral traits in sand lizards found in six areas of the Republic of Tatarstan is considered. Asymmetric features are estimated statistically; integral characteristics of fluctuating asymmetry are presented. The asymmetry in the number of femoral pores, cheek scutes, and supraciliar scutes is more common. Most of the characteristics demonstrate fluctuating asymmetry. It is observed in 41% of all the individuals. There are neither significant sex nor age differences in the values of fluctuating asymmetry. The populations from Bekser, Kordon and Spassk differ from the others by high levels of fluctuating asymmetry, and these differences can be explained by isolation, the genetic structure of populations, microclimatic conditions and other factors

NATIONAL SELF-CONSCIOUSNESS OF STUDENTS IN HIGHER EDUCATIONAL STUDIES IN THE REPUBLIC OF TATARSTAN BY MEANS OF HUMANITARIAN DISCIPLINES

Purpose: The article describes the view of the author to the actualization of national consciousness of students by means of humanitarian disciplines. The processes of globalization and integration of Tatarstan Republic into the world space exacerbate the problem of preserving the uniqueness and identity, national cultures in the conditions of cultural diversity. Methodology: To solve the problems, we used the following research methods: theoretical (study and analysis of philosophical, psychological, ethnological, sociological, pedagogical, cultural, linguistic, methodological and other literature on the research topic); empirical (pedagogical observation, group and individual conversations, oral and written surveys, testing, questioning, pedagogical experiment); mathematical methods (registration of obtained data, method of mathematical processing of experimental research results). Result: The analysis of the research showed that developed national self-consciousness promotes spiritual development and self-development of the individual. National self-consciousness is the recognition of belonging to a certain national community, along with a positive assessment of representatives of other national cultures, the individual's representation of language, culture, typical features of the community, the common historical past, religion, territory, and statehood. Applications: This research can be used for the universities, teachers, and students. Novelty/Originality: In this research, the model of National Self-Consciousness of Students in Higher Educational Studies in the Republic of Tatarstan by Means of Humanitarian Disciplines is presented in a comprehensive and complete manner

Прецизионная терапия больных псориазом

In this review, we systematized information in a new direction — precision medicine in the aspect of the study of psoriasis. An idea of relevance, basic concepts is given, a modern classification of biomarkers is given. Examples of each type of biomarker are presented, their role in the diagnosis and treatment of patients. The relationship of a personalized and precise approach to patient management is indicated. The main directions of development of this section of medicine are indicated.В данном обзоре проведена систематизация сведений по новому направлению — прецизионной медицине в аспекте изучения псориаза. Дано представление об актуальности, базовых понятиях, приведена современная классификация биомаркеров. Представлены примеры каждого типа биомаркера, их роль в диагностике и лечении больных. Указана взаимосвязь персонализированного и прецизионного подхода к ведению пациентов. Обозначены основные направления развития данного раздела медицины