Risk-oriented technique of real investments management: Consepts

© 2014, Mediterranean Center of Social and Educational Research. All rights reserved. One of the main objectives of real investment management is increasing in company’s revenues and market value. Long time lag of income from investments, the scale of investments, and a high level of uncertainty in their implementation makes the questions of project risk management actual. We focused on systematization of methods to measure, report and manage project risks. The paper suggests the concepts of risk-oriented methodology of project risk management. We assumed similar results ranking of investment projects in terms of risks, using Monte Carlo simulation and the fuzzy sets theory for risk assessment. In this study, was formed the empirical base, including investment projects of Russian pharmaceutical companies. The obtained results confirmed our hypothesis

Determination of the Optimal Number of Realizations of the Modulating Sequence of the PSK-n signal Necessary for Estimating the Error Probability per Symbol Caused by the ISI Produced by Linear Selective Systems

© 2018 IEEE. the problem of estimation of the optimal number of realizations for necessary PSK-n modulating sequence to estimate symbol error rate caused by ISI produced by linear selective systems is considered in the paper. Estimation of the optimal realization number for this case is carried out based on numerical simulation of communicating channel. Dependencies, which allow to estimate value of specific number of optimal of realization per discrete state, are shown in the article, appropriate recommendations are provided

Myogenic Trigger Zone of Trapezius Muscle Increases the Tone of the Middle Cerebral Artery

© 2016, Springer Science+Business Media New York.A myogenic trigger zone (MTZ) has been shown to affect the tone of the surface arteries of the head and lower limbs. However, it remains largely unknown whether the tone of the intracranial arteries is regulated by MTZ. The aim of the present study was to investigate the effect of MTZ in trapezius muscle on the tone of the middle cerebral artery. Using ultrasound measurements of the peak velocity of blood flow and the Lindegaard index (LI), we found that the presence of an active MTZ in a trapezius muscle was per se associated with an increased LI values and that pressure stimulation of the MTZ further increases LI. When MTZ was eliminated by means of manual therapy, the indices of blood flow and LI returned to normal values. We conclude that the reflex spasm of the middle cerebral artery can occur in the presence of an active MTZ-TM and that this phenomenon contributes to the pathogenesis and the clinical symptoms associated with the cervicogenic and tension headaches

Cognitive impairment in diabetes mellitus and hypertension, a possibility of correction

Objective: to evaluate cognitive functions in patients with type 2 diabetes mellitus (DM2) and hypertension and the efficacy of Ginkgo biloba extract Egb 761®. Patients and methods: 120 patients with DM2 and 50 hypertensive patients with no complications or a history of stroke and/or myocardial infarction, without active complaints of hypomnesia and other cognitive functions were examined. The exclusion criteria were prior stroke and/or myocardial infarction; clinically significant diseases of the peripheral arteries and major arteries of the head; DM2 decompensation; glomerular filtration rate <60 ml/min; proliferative retinopathy; and other endocrine diseases. The investigators used the following methods for the evaluation of cognitive functions: the Mini-Mental State Examination, the Montreal Cognitive Assessment, and the hand-eye coordination test (Parts A and B). Results and discussion: 85% of the patients with DM2 were found to have cognitive impairments (CI): disorders of attention, short-term memory, and thinking speed. Out of them, 82.5% had moderate CI and 2.5% had dementia. 30% of the hypertensive patients were diagnosed as having moderate CIs and 10% had dementia. At the same time, the degree of CI was higher in the patients with MD2 than in those with hypertension. The use of Egb 761® 240 mg/day for 3 months had a statistically significant positive impact on cognitive functions (improvements in short-term memory, concentration, and thinking speed) and everyday activity. Conclusion: The authors consider that CIs are the first sign of encephalopathy in DM2. It is also noted that DM2 has a more pronounced impact on cognitive functions than hypertension. Egb 761® can be used as an effective drug to treat CI in these diseases

Key performance indicators in corporate finance

© 2015, Asian Social Science. All rights reserved. The relevance of the study caused by the necessity to assess the impact of KPI system for growth of shareholders welfare and the satisfaction of the interests of other stakeholders. KPI concept suggests widespread use of these factors as measures of internal and external efficiency, as well as an incentive for management to meet the strategic objectives of the company. The article examines the influence of key performance indicators on the value of Russian companies. We used the following tools of econometric research: content analysis and econometric modeling to conduct the study

National traditions as a means to upbringing humanity in teenagers

© 2016 by iSER, International Society of Educational Research.The relevance of the research is proved due to the following. The educational sphere in Russia, that includes an upbrining component as well, is undergoing nowadays quality changes the cornerstone of which is the comprehension of universal values and a focus on the rational use of the experience that has been accumulated in the world education. The appeal in this context to the richest heritage of national upbringing traditions as the foundation for the solution of modern problems in humanistic upbrining of the youth is, in our opinion, urgent and relevant. In this regard the article aimes to identify pedagogical conditions of teenagers’ humanity upbringing with progressive national traditions in view. The leading research methods were systematization and generalization of historical-pedagogical facts and concepts, the analysis of actions results, teenagers’ activity and behavior, study and synthesis of educational institutions experience in learners’ humanity upbringing and the use of progressive national traditions in this process, diagnostic techniques, pedagogic experiment. In the article characteristics of teenagers’ humany development have been revealed; criteria of teenagers’ humanity development have been singled out; pedagogical conditions necessary and sufficient for upbringing teenagers’ humanity on progressive national traditions have been substantiated. The materials of this article may be useful to school teachers, guidance teachers, tutors, providers of education

World population estimates and projections: Data and methods

In work results of the carried-out demographic forecasting as in general for the world and by certain parts of the world (Africa, South America, North America, Asia, Europe) are provided. It allowed to carry out at the same time the analysis of the population growth dynamics by groups of the countries "North" - "South". The analysis of the world population dynamics and certain parts of the world during 1950 - 2010 allowed to carry out the forecast of the world population and certain parts of the world before 2050. In work methods of regression and correlation analysis were applied. The received results in case of the various options choice like the approximating functions differ in the high level of the actual compliance and calculated values, i.e. insignificant errors of approximation,in case of high significance value of results (p>0.05). In the course of forecasting it was revealed that in the first half of the 21st century population growth will continue. This growth will be extremely uneven both on continents, and over groups of the countries. As a result of globalization processes the stage of demographic transition will be entered by all countries of the world (though differentiation in this plan will be very essential). In the second half of the century the period of demographic stabilization at the planetary level will begin

The Influence of Diabetes Mellitus Duration and Type of Therapy on Cognitive Decline

© 2016, Springer Science+Business Media New York.We studied 120 patients with compensated diabetes mellitus type 2 (DM-2). The inclusion criterion was the absence of memory loss complaints from the patient and/or his/her relatives. The exclusion criteria were diabetes decompensation, myocardial infarction and/or stroke in anamnesis, glomerular filtration rate below 60 ml/min, the presence of proliferative retinopathy, and/or other endocrine diseases. To diagnose the cognitive decline (CD) we used Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA test), Trail Making Test (parts A and B). 77.5 % patients with type 2 diabetes out of 120 had moderate CD; 5 % had a significant CD (dementia). The control group consisted of 50 patients with arterial hypertension, which was comparable with the DM-2 group. In assessing the correlations, we found that the CD in DM-2 group is independent of disease duration and the type of diabetic therapy. We discovered a positive correlation between the age of patients and the speed of cognitive decline. Comparison of patients in DM-2 group with the control group showed that results in patients with hypertension (MMSE, MoCA test) were significantly higher (p < 0.01), and the test time of TMT part A and part B was significantly lower (p < 0.01) than that in patients with DM-2. The authors believe that the CD in DM-2 has different pathogenic mechanisms than other complications of type 2 diabetes mellitus, in particular, the insulin resistance of brain tissue

Quality of Life in Patients with Type 2 Diabetes Mellitus

© 2016, Springer Science+Business Media New York.The article presents the results of a survey which included 120 patients with type 2 diabetes mellitus (DM-2) without complications, without stroke in anamnesis, with no active complaints about loss of memory, and/or other cognitive functions. The assessment tools for cognitive functions were MMSE, MoCA test, and TMT (parts A and B). SF-36 test was used to assess the quality of life (QoL). It was revealed that the QoL in patients with type 2 diabetes was significantly lower than in the general population. The correlation between QoL and the duration of the disease, the degree of cognitive impairment, and emotional state of patients was evaluated. It was revealed that QoL indicators significantly reduced with the growth of cognitive impairment and emotional disorders. The most significant reduction is revealed in the role functioning indexes and role-emotional functioning indexes

Tension type headache: GABA-ergic drug anvifen efficacy

© 2016, Media Sphera. All rights reserved.Objective. To assess the efficacy of aminophenylbutyric acid (anvifen), a synthetic GABA-receptor agonist, in the treatment of adult patients with tension type headache (TTH). Material and methods. Eighty-seven patients with episodic TTH (ETTH) and 30 patients with chronic TTH (CTTH) were examined. The area under the headache curve, sleep quality, the Hospital Anxiety and Depression Scale (HADS) scores and stress resistance measured by an original questionnaire were evaluated. Results. Anvifen in dose of 250 mg TID during 3 weeks had a positive effect on all parameters studied, excluding the area under the headache curve in CTTH. Similar results were demonstrated after the subsequent course of treatment for 3 weeks. Conclusion. Anvifen was highly effective in ETTH but less effective in CTTH. A combination of anvifen with antidepressants can be recommended for patients with CTTH