Epidemiological pattern of corneal foreign bodies and utilization of protective eye devices: a hospital-based cross-sectional study

Introduction: A corneal foreign body is the most common occupational ocular injury that can cause secondary infection or scars on the visual axis, decreasing vision. The study aimed to find out practices of wearing protective eye devices in the workplace and the factors influencing the utilization of such devices among patients with corneal foreign body (CFB) injury. Methods: This cross-sectional study was conducted in a tertiary eye hospital in Bhaktapur from April 2021 to August 2021. All patients with CFB attending the hospital were included in the study. CFB was removed with ocular examination under a slit lamp biomicroscope, and face-to-face interview was conducted. Results: Among 142 patients, only one was female, and 41.5% had a previous history of CFB. The most common CFB particle was metallic (n=124, 87.3%),. Three-fourths (75.1%) of patients were not using eye-protective devices at the time of injury, and 45.1% tried physically removing the CFB in a harmful way. Nearly two in five (19.7%) had used topical antibiotics eye drops before presenting for CFB removal. Sixty-six (46.5%) reported never wearing any protective eye devices, and the main reason for not-wearing was the unavailability (48.4%) of such devices in their workplace. The awareness of the need for protective eye devices (p<0.001) was significantly associated with using protective eye devices during work. Conclusion: The workers should be made aware of the consequences of harmful practices following CFB injury. The workers should wear protective eye devices to minimize the risk of ocular injury and consequent visual impairment

Comparative Study of Carbon Stock and Tree Diversity between Scientifically and Conventionally Managed Community Forests of Kanchanpur District, Nepal

The present study was accomplished to assess and compare tree diversity, carbon stock, and to find the relationship between carbon stock and tree diversity in scientifically and conventionally managed community forests (CFs) of Kanchanpur District, Nepal. A total of 94 sample plots were overlaid with a systematic random sampling method (51 plots in scientifically managed Singhapur CF and 43 plots were established in conventionally managed Kalika CF). The height and DBH of each tree were measured to calculate biomass and carbon stock. Shannon-Wiener and Simpson’s indexes were calculated for tree diversity. The data were pooled and analyzed using MS Excel and SPSS software. The values were statistically compared using a t-test. The total carbon stock and tree diversity were higher in scientifically managed CF (207.58 tons/ha and H= 0.97) than conventionally managed CF (183.72 tons/ha and H=0.85). Shorea robusta has a major contribution on total carbon stock in both CFs (Kalika: 66.34% and Singhapur: 70.43%) followed by Terminalia tomentosa (Kalika: 24.65% and Singhapur: 13.36%). The t-test did not show any significant difference for the mean values of carbon stocks and tree diversity between the CFs at a 5% level of significance. However, carbon stock showed a weak but positive relationship with species richness and negative with evenness. The result of the study recommends managing forests scientifically for increased tree diversity leading to enhanced carbon deposition

STUDY OF IN VITRO ANTI-OXIDANT AND ANTI-DIABETIC ACTIVITY BY MUSSAENDA MACROPHYLLA ROOT EXTRACTS

Objective: The systematic study of effective alternative anti-diabetic drugs has great importance to manage diabetes as well as other oxidative stress-related diseases. According to previous research, root and bark of Mussaenda macrophylla plant has anti-microbial, anti-coagulant, anti-inflammatory, and hepatoprotective activity. Ethnomedicinal data shows that Mussaenda macrophylla is used to treat diabetes as well as oxidative stress. The objective of this research is to investigate in vitro anti-diabetic and anti-oxidant activity of root extract of Mussaenda macrophylla. Methods: DPPH free radical scavenging assay was used to detect anti-oxidant potency of ethanol and methanol root extract of the plant and expressed as % of radicle inhibition. Anti-diabetic activity was determined by the glucose diffusion method using a glucose oxidase kit and results were expressed as mean±SD. Results: The ethanol root extract at the concentration of 50 mg/ml and 100 mg/ml showed better glucose diffusion inhibition than that of methanol extract at the same concentration on increasing time interval. Ethanol extract at the concentration 100 µg/ml displayed better DPPH scavenging activity (89.83±0.19 %) than that of methanol extract (86.61±0.75%). Conclusion: This study concluded that ethanol and methanol root extract of Mussenda macrophylla have potent anti-diabetic as well as anti-oxidant activity but further advance research is necessary in the animal model

Farmers’ seed networks and agrobiodiversity conservation for sustainable food security: a case from the mid-hills of Nepal

This paper was funded by the International Development Research Centre as well as Global Affairs Canada.This paper evaluates the nature and functioning of seed networks for rice, maize and finger millet, and explores the effect of such networks on agrobiodiversity conservation and food security. Using snowball sampling, ninety-five farmers from the Dhikurpokhari Village Development Committee in Kaski district, a representative site for western mid-hills of Nepal, were interviewed. Data were collected through semi-structured interviews, focus group discussions and field observations. Social network analysis tools and maps, with the help of NetDraw software, were used to examine the status of the network and identify the key nodal and connector farmers. It was revealed that there is a loose network of seed exchange in the community, varying according to crop. While nodal farmers play a more pivotal role than other farmers in seed exchange, only marginal differences were found in the characteristics of nodal and non-nodal farmers, apart from their age and education. More than 90% of farmers had saved seeds of maize and finger millet on their own, mainly local varieties, while only 70% of farmers had saved rice seed. Farmers’ practices of saving seed at home, limited varietal options in locality, a declining interest in agriculture, rural-to-urban migration and thence scarcity of labour have all contributed to a reduction in the exchange of seed. This in turn has affected the on-farm conservation of agrobiodiversity and food security at the local level

Analysis of cardiac autonomic modulation in normotensive obese and eutrophic adults of Nepal

Background: Obese people have a higher prevalence of cardiovascular disease, though unknown mechanism, supposed to be due to autonomic dysfunction which is still in controversy. This study aimed to assess and compare heart rate variability (HRV) between normotensive obese and adults.Methods: The study was conducted on 30 normotensive obese adults (mean age 32.07±7.25 years) with BMI>30 and 29 age- and sex-matched normal weight controls (mean age 30.48±8.01 years) with BMI: 18-24 Kg/m2. Short-term HRV variables were assessed using standard protocol. The data were compared between the groups using Mann Whitney ‘U’ test.Results: In obese group, there was significant increase in the mean heart rate [79.17±8.80 Vs 71.48±8.41 beats/min, p=0.001], systolic blood pressure [121.20±9.89 Vs 113.24±11.07, mmHg, p=0.004] and diastolic blood pressure [84.97±7.87 Vs 74.83±10.31 mmHg, p=0.000]. The HRV parasympathetic indicators were less [RMSSD {28.75(16.72-38.35) Vs 41.55(30.6-56.75) ms, p=0.018}, NN50 {15.5(2-39) Vs 83.5(32.75-116.25), p=0.010}], and sympathetic indicator LF/HF ratio [1.2(0.65-2.20) Vs 0.79(0.5-1.02), p=0.004] was more in obese group.Conclusions: Obese persons have increased sympathetic activity with a reduction in parasympathetic (vagal) tone indicating poor autonomic cardiac rhythm control. Moreover, the altered autonomic activity could be the reason for increased mean heart rate and blood pressures in normotensive obese persons

Geotechnical Effects of the 2015 Magnitude 7.8 Gorkha, Nepal, Earthquake and Aftershocks

This article summarizes the geotechnical effects of the 25 April 2015 M 7.8 Gorkha, Nepal, earthquake and aftershocks, as documented by a reconnaissance team that undertook a broad engineering and scientific assessment of the damage and collected perishable data for future analysis. Brief descriptions are provided of ground shaking, surface fault rupture, landsliding, soil failure, and infrastructure performance. The goal of this reconnaissance effort, led by Geotechnical Extreme Events Reconnaissance, is to learn from earthquakes and mitigate hazards in future earthquakes