Demonstration of surface electron rejection with interleaved germanium detectors for dark matter searches

The SuperCDMS experiment in the Soudan Underground Laboratory searches for dark matter with a 9-kg array of cryogenic germanium detectors. Symmetric sensors on opposite sides measure both charge and phonons from each particle interaction, providing excellent discrimination between electron and nuclear recoils, and between surface and interior events. Surface event rejection capabilities were tested with two [superscript 210] Pb sources producing ∼130 beta decays/hr. In ∼800 live hours, no events leaked into the 8–115 keV signal region, giving upper limit leakage fraction 1.7 × 10[superscript −5] at 90% C.L., corresponding to < 0.6 surface event background in the future 200-kg SuperCDMS SNOLAB experiment.United States. Dept. of Energy (Contract No. DE-AC03-76SF00098)United States. Dept. of Energy (Contract No. DE-FG02-92ER40701)United States. Dept. of Energy (Contract No. DE-FG02-94ER40823)United States. Dept. of Energy (Contract No. DE-FG03-90ER40569)United States. Dept. of Energy (Contract No. DE-FG03-91ER40618)United States. Dept. of Energy (Contract No. DE-SC0004022)National Science Foundation (U.S.) (Grant No. AST-9978911)National Science Foundation (U.S.) (Grant No. NSF-0847342)National Science Foundation (U.S.) (Grant No. PHY-1102795)National Science Foundation (U.S.) (Grant No. NSF-1151869)National Science Foundation (U.S.) (Grant No. PHY-0542066)National Science Foundation (U.S.) (Grant No. PHY-0503729)National Science Foundation (U.S.) (Grant No. PHY-0503629)National Science Foundation (U.S.) (Grant No. PHY-0503641)National Science Foundation (U.S.) (Grant No. PHY-0504224)National Science Foundation (U.S.) (Grant No. PHY-0705052)National Science Foundation (U.S.) (Grant No. PHY-0801708)National Science Foundation (U.S.) (Grant No. PHY-0801712)National Science Foundation (U.S.) (Grant No. PHY-0802575)National Science Foundation (U.S.) (Grant No. PHY-0847342)National Science Foundation (U.S.) (Grant No. PHY-0855299)National Science Foundation (U.S.) (Grant No. PHY-0855525)National Science Foundation (U.S.) (Grant No. PHY-1205898

Till the ocean do us part: Italian and American therapists representations of stepfamilies in treatment

Research often focuses on the characteristics of stepfamilies and their differences with first-union families; however, few studies take into account the therapis's perspective with regards to the treatment of such families. Also, cross-cultural research on the topic is limited. To fill these gaps, a content analysis of responses from 125 Italian and 45 American therapists regarding their representations of stepfamilies and stepfamily therapy was undertaken. Results show that American therapists emphasized specific stepfamily characteristics (e.g., the lack of a shared family history, the occurrence of conflict between former spouses, the presence of unrealistic expectations towards treatment) to a greater extent if compared to Italian therapists. By contrast, besides being more general in their definition of stepfamilies, Italian therapists focused more on themselves, their theoretical models, and their professional and personal skills. The study provides insights on both the differences in the clinical cultures of the two countries and implications for stepfamily therapy and training

Vitamin and Mineral Supplementation and Rate of Gain in Beef Heifers II: Effects on Concentration of Trace Minerals in Maternal Liver and Fetal Liver, Muscle, Allantoic, and Amniotic Fluids at Day 83 of Gestation

We evaluated the effects of vitamin and mineral supplementation (from pre-breeding to day 83 of gestation) and two rates of gain (from breeding to day 83 of gestation) on trace mineral concentrations in maternal and fetal liver, fetal muscle, and allantoic (ALF) and amniotic (AMF) fluids. Crossbred Angus heifers (n = 35; BW = 359.5 ± 7.1 kg) were randomly assigned to one of two vitamin and mineral supplementation treatments (VMSUP; supplemented (VTM) vs. unsupplemented (NoVTM)). The VMSUP factor was initiated 71 to 148 d before artificial insemination (AI), allowing time for the mineral status of heifers to be altered in advance of breeding. The VTM supplement (113 g·heifer−1·d−1) provided macro and trace minerals and vitamins A, D, and E to meet 110% of the requirements specified by the NASEM, and the NoVTM supplement was a pelleted product fed at a 0.45 kg·heifer−1·day−1 with no added vitamin and mineral supplement. At AI, heifers were assigned to one of two rates of gain treatments (GAIN; low gain (LG) 0.28 kg/d or moderate gain (MG) 0.79 kg/d) within their respective VMSUP groups. On d 83 of gestation fetal liver, fetal muscle, ALF, and AMF were collected. Liver biopsies were performed prior to VMSUP factor initiation, at the time of AI, and at the time of ovariohysterectomy. Samples were analyzed for concentrations of Se, Cu, Zn, Mo, Mn, and Co. A VMSUP × GAIN × day interaction was present for Se and Cu (p \u3c 0.01 and p = 0.02, respectively), with concentrations for heifers receiving VTM being greater at AI and tissue collection compared with heifers not receiving VTM (p \u3c 0.01). A VMSUP × day interaction (p = 0.01) was present for Co, with greater (p \u3c 0.01) concentrations for VTM than NoVTM at the time of breeding. VTM-MG heifers had greater concentrations of Mn than all other treatments (VMSUP × GAIN, p \u3c 0.01). Mo was greater (p = 0.04) for MG than LG, while Zn concentrations decreased throughout the experiment (p \u3c 0.01). Concentrations of Se (p \u3c 0.01), Cu (p = 0.01), Mn (p = 0.04), and Co (p = 0.01) were greater in fetal liver from VTM than NoVTM. Mo (p ≤ 0.04) and Co (p \u3c 0.01) were affected by GAIN, with greater concentrations in fetal liver from LG than MG. In fetal muscle, Se (p = 0.02) and Zn (p \u3c 0.01) were greater for VTM than NoVTM. Additionally, Zn in fetal muscle was affected by GAIN (p \u3c 0.01), with greater concentrations in LG than MG. The ALF in VTM heifers (p \u3c 0.01) had greater Se and Co than NoVTM. In AMF, trace mineral concentrations were not affected (p ≥ 0.13) by VMSUP, GAIN, or their interaction. Collectively, these data suggest that maternal nutrition pre-breeding and in the first trimester of gestation affects fetal reserves of some trace minerals, which may have long-lasting impacts on offspring performance and health

The WiggleZ Dark Energy Survey: Direct constraints on blue galaxy intrinsic alignments at intermediate redshifts

Correlations between the intrinsic shapes of galaxy pairs, and between the intrinsic shapes of galaxies and the large-scale density field, may be induced by tidal fields. These correlations, which have been detected at low redshifts (z<0.35) for bright red galaxies in the Sloan Digital Sky Survey (SDSS), and for which upper limits exist for blue galaxies at z~0.1, provide a window into galaxy formation and evolution, and are also an important contaminant for current and future weak lensing surveys. Measurements of these alignments at intermediate redshifts (z~0.6) that are more relevant for cosmic shear observations are very important for understanding the origin and redshift evolution of these alignments, and for minimising their impact on weak lensing measurements. We present the first such intermediate-redshift measurement for blue galaxies, using galaxy shape measurements from SDSS and spectroscopic redshifts from the WiggleZ Dark Energy Survey. Our null detection allows us to place upper limits on the contamination of weak lensing measurements by blue galaxy intrinsic alignments that, for the first time, do not require significant model-dependent extrapolation from the z~0.1 SDSS observations. Also, combining the SDSS and WiggleZ constraints gives us a long redshift baseline with which to constrain intrinsic alignment models and contamination of the cosmic shear power spectrum. Assuming that the alignments can be explained by linear alignment with the smoothed local density field, we find that a measurement of \sigma_8 in a blue-galaxy dominated, CFHTLS-like survey would be contaminated by at most +/-0.02 (95% confidence level, SDSS and WiggleZ) or +/-0.03 (WiggleZ alone) due to intrinsic alignments. [Abridged]Comment: 18 pages, 12 figures, accepted to MNRAS; v2 has correction to one author's name, NO other changes; v3 has minor changes in explanation and calculations, no significant difference in results or conclusions; v4 has an additional footnote about model interpretation, no changes to data/calculations/result

JWST/NIRCam Imaging of Young Stellar Objects. II. Deep Constraints on Giant Planets and a Planet Candidate Outside of the Spiral Disk Around SAO 206462

We present JWST/NIRCam F187N, F200W, F405N and F410M direct imaging data of the disk surrounding SAO 206462. Previous images show a very structured disk, with a pair of spiral arms thought to be launched by one or more external perturbers. The spiral features are visible in three of the four filters, with the non-detection in F410M due to the large detector saturation radius. We detect with a signal-to-noise ratio of 4.4 a companion candidate (CC1) that, if on a coplanar circular orbit, would orbit SAO 206462 at a separation of $\sim300$ au, $2.25\sigma$ away from the predicted separation for the driver of the eastern spiral. According to the BEX models, CC1 has a mass of $M_\mathrm{CC1}=0.8\pm0.3~M_\mathrm{J}$. No other companion candidates were detected. At the location predicted by simulations of both spirals generated by a single massive companion, the NIRCam data exclude objects more massive than $\sim2.2~M_\mathrm{J}$ assuming the BEX evolutionary models. In terms of temperatures, the data are sensitive to objects with $T_{\text{eff}}\sim650-850$ K, when assuming planets emit like blackbodies ($R_\mathrm{p}$ between 1 and $3 R_\mathrm{J}$). From these results, we conclude that if the spirals are driven by gas giants, these must be either cold or embedded in circumplanetary material. In addition, the NIRCam data provide tight constraints on ongoing accretion processes. In the low extinction scenario we are sensitive to mass accretion rates of the order $\dot{M}\sim10^{-9} M_\mathrm{J}$ yr$^{-1}$. Thanks to the longer wavelengths used to search for emission lines, we reach unprecedented sensitivities to processes with $\dot{M}\sim10^{-7} M_\mathrm{J}$ yr$^{-1}$ even towards highly extincted environments ($A_\mathrm{V}\approx50$~mag).Comment: 18 pages, 8 figures, 3 table

JWST/NIRCam Imaging of Young Stellar Objects. I. Constraints on Planets Exterior to The Spiral Disk Around MWC 758

MWC 758 is a young star hosting a spiral protoplanetary disk. The spirals are likely companion-driven, and two previously-identified candidate companions have been identified -- one at the end the Southern spiral arm at ~0.6 arcsec, and one interior to the gap at ~0.1 arcsec. With JWST/NIRCam, we provide new images of the disk and constraints on planets exterior to ~1". We detect the two-armed spiral disk, a known background star, and a spatially resolved background galaxy, but no clear companions. The candidates that have been reported are at separations that are not probed by our data with sensitivity sufficient to detect them -- nevertheless, these observations place new limits on companions down to ~2 Jupiter-masses at ~150 au and ~0.5 Jupiter masses at ~600 au. Owing to the unprecedented sensitivity of JWST and youth of the target, these are among the deepest mass-detection limits yet obtained through direct imaging observations, and provide new insights into the system's dynamical nature.Comment: Accepted for publication in A

Maternal Vitamin and Mineral Supplementation and Rate of Maternal Weight Gain Affects Placental Expression of Energy Metabolism and Transport-Related Genes

Maternal nutrients are essential for proper fetal and placental development and function. However, the effects of vitamin and mineral supplementation under two rates of maternal weight gain on placental genome-wide gene expression have not been investigated so far. Furthermore, biological processes and pathways in the placenta that act in response to early maternal nutrition are yet to be elucidated. Herein, we examined the impact of maternal vitamin and mineral supplementation (from pre-breeding to day 83 post-breeding) and two rates of gain during the first 83 days of pregnancy on the gene expression of placental caruncles (CAR; maternal placenta) and cotyledons (COT; fetal placenta) of crossbred Angus beef heifers. We identified 267 unique differentially expressed genes (DEG). Among the DEGs from CAR, we identified ACAT2, SREBF2, and HMGCCS1 that underlie the cholesterol biosynthesis pathway. Furthermore, the transcription factors PAX2 and PAX8 were over-represented in biological processes related to kidney organogenesis. The DEGs from COT included SLC2A1, SLC2A3, SLC27A4, and INSIG1. Our over-representation analysis retrieved biological processes related to nutrient transport and ion homeostasis, whereas the pathways included insulin secretion, PPAR signaling, and biosynthesis of amino acids. Vitamin and mineral supplementation and rate of gain were associated with changes in gene expression, biological processes, and KEGG pathways in beef cattle placental tissues

Untangling the placentome gene network of beef heifers in early gestation

The cotyledon and caruncle tissues provide a functional bridge between the fetus and the dam. However, the relationship between these tissues and the transcriptomic profile that underlies the tissue functions remains elusive. Herein we investigate the expression profile of cotyledon and caruncle from nulliparous beef heifers carrying female fetuses at day 83 of pregnancy to identify changes occurring across tissues that contribute to placental function and their tissue-specific roles. We identified 2654 differentially expressed genes [padj ≤ 0.05, abs(log2FC) ≥ 1], including nutrient transporters and paternally imprinted genes. We found key regulators of tissue function and differentiation, including FOXO4, GATA2, GATA3, and HAND1, rewired between the tissues. Finally, we shed light on the over-represented pathways related to immune tolerance, tissue differentiation and remodeling. Our findings highlighted the intricate and coordinated cross-talk between fetal-maternal tissues. They provided evidence of a fine-tuned gene regulatory network underlying pregnancy and tissue-specific function in the bovine placenta

Vitamin and Mineral Supplementation and Rate of Weight Gain during the First Trimester of Gestation in Beef Heifers Alters the Fetal Liver Amino Acid, Carbohydrate, and Energy Profile at Day 83 of Gestation

The objective of this study was to evaluate the effects of feeding heifers a vitamin and mineral supplement and targeting divergent rates of weight gain during early gestation on the fetal liver amino acid, carbohydrate, and energy profile at d 83 of gestation. Seventy-two crossbred Angus heifers were randomly assigned in a 2 × 2 factorial arrangement to one of four treatments comprising the main effects of vitamin and mineral supplementation (VTM or NOVTM) and feeding to achieve different rates of weight gain (low gain [LG] 0.28 kg/day vs. moderate gain [MG] 0.79 kg/day). Thirty-five gestating heifers with female fetuses were ovariohysterectomized on d 83 of gestation and fetal liver was collected and analyzed by reverse phase UPLC-tandem mass spectrometry with positive and negative ion mode electrospray ionization, as well as by hydrophilic interaction liquid chromatography UPLC-MS/MS with negative ion mode ESI for compounds of known identity. The Glycine, Serine, and Threonine metabolism pathway and the Leucine, Isoleucine, and Valine metabolism pathway had a greater total metabolite abundance in the liver of the NOVTM-LG group and least in the VTM-LG group (p \u3c 0.01). Finally, both the TCA Cycle and Oxidative Phosphorylation pathways within the Energy Metabolism superpathway were differentially affected by the main effect of VTM, where the TCA cycle metabolites were greater (p = 0.04) in the NOVTM fetal livers and the Oxidative Phosphorylation biochemicals were greater (p = 0.02) in the fetal livers of the VTM supplemented heifers. These data demonstrate that the majority of metabolites that are affected by rate of weight gain or vitamin/mineral supplementation are decreased in heifers on a greater rate of weight gain or vitamin/mineral supplementation

The Milky Way Tomography with SDSS: III. Stellar Kinematics

We study Milky Way kinematics using a sample of 18.8 million main-sequence stars with r<20 and proper-motion measurements derived from SDSS and POSS astrometry, including ~170,000 stars with radial-velocity measurements from the SDSS spectroscopic survey. Distances to stars are determined using a photometric parallax relation, covering a distance range from ~100 pc to 10 kpc over a quarter of the sky at high Galactic latitudes (|b|>20 degrees). We find that in the region defined by 1 kpc <Z< 5 kpc and 3 kpc <R< 13 kpc, the rotational velocity for disk stars smoothly decreases, and all three components of the velocity dispersion increase, with distance from the Galactic plane. In contrast, the velocity ellipsoid for halo stars is aligned with a spherical coordinate system and appears to be spatially invariant within the probed volume. The velocity distribution of nearby ($Z<1$ kpc) K/M stars is complex, and cannot be described by a standard Schwarzschild ellipsoid. For stars in a distance-limited subsample of stars (<100 pc), we detect a multimodal velocity distribution consistent with that seen by HIPPARCOS. This strong non-Gaussianity significantly affects the measurements of the velocity ellipsoid tilt and vertex deviation when using the Schwarzschild approximation. We develop and test a simple descriptive model for the overall kinematic behavior that captures these features over most of the probed volume, and can be used to search for substructure in kinematic and metallicity space. We use this model to predict further improvements in kinematic mapping of the Galaxy expected from Gaia and LSST.Comment: 90 pages, 26 figures, submitted to Ap