Performance improvements of an F-15 airplane with an integrated engine-flight control system

An integrated flight and propulsion control system has been developed and flight demonstrated on the NASA Ames-Dryden F-15 research aircraft. The highly integrated digital control (HIDEC) system provides additional engine thrust by increasing engine pressure ratio (EPR) at intermediate and afterburning power. The amount of EPR uptrim is modulated based on airplane maneuver requirements, flight conditions, and engine information. Engine thrust was increased as much as 10.5 percent at subsonic flight conditions by uptrimming EPR. The additional thrust significantly improved aircraft performance. Rate of climb was increased 14 percent at 40,000 ft and the time to climb from 10,000 to 40,000 ft was reduced 13 percent. A 14 and 24 percent increase in acceleration was obtained at intermediate and maximum power, respectively. The HIDEC logic performed fault free. No engine anomalies were encountered for EPR increases up to 12 percent and for angles of attack and sideslip of 32 and 11 degrees, respectively

Static Structures and Dynamic Processes of Participation and Access: a Case Study of Connemara Community Radio

CONNEMARA COMMUNITY RADIO (CCR) is a community-based radio station broadcasting from Letterfrack in the North West Connemara area of Co. Galway since 1995. On air for 10 hours daily, it is possibly the smallest community radio station in Ireland serving a remote, yet large and sparsely populated rural franchise area. One of the main motivations behind CCR’s original establishment was that the radio station would promote community development in its franchise area (Day, 2007b; Heanue, 2002). Set against the literatures on community radio (Day, 2007a, b; Kanayama, 2007; Rennie, 2006; Sánchez, 2003; Heanue, 2002; Girard, 1992) and community development (Tilly, 2004; Moseley, 2003; Varley and Curtin, 2002; Lowe et al., 1998; Mannion, 1996; Curtin et al., 1991; Varley, 1991; Griffiths, 1974; Armstrong, 1971) this article uses a mixture of quantitative and qualitative data collected over the period 2000 to 2008 to analyse the community development aspects of this radio station. The explicit community development focus is important for two reasons. First, as a core principle, community radio seeks to contribute to community development. Second, North West Connemara as a remote, economically challenged rural area relies heavily on endogenous development and has a long-standing and vibrant community development sector (see Heanue et al., 2012). A central objective behind the establishment of CCR by Connemara West Plc was to support and engage in community development efforts. This article seeks to assess the extent to which that objective is being reached by describing and analysing various indicators and processes of participation of local people with the radio station and the form of access they have to it

Water Delivery and Giant Impacts in the 'Grand Tack' Scenario

A new model for terrestrial planet formation (Hansen 2009, Walsh et al. 2011) has explored accretion in a truncated protoplanetary disk, and found that such a configuration is able to reproduce the distribution of mass among the planets in the Solar System, especially the Earth/Mars mass ratio, which earlier simulations have generally not been able to match. Walsh et al. tested a possible mechanism to truncate the disk--a two-stage, inward-then-outward migration of Jupiter and Saturn, as found in numerous hydrodynamical simulations of giant planet formation. In addition to truncating the disk and producing a more realistic Earth/Mars mass ratio, the migration of the giant planets also populates the asteroid belt with two distinct populations of bodies--the inner belt is filled by bodies originating inside of 3 AU, and the outer belt is filled with bodies originating from between and beyond the giant planets (which are hereafter referred to as `primitive' bodies). We find here that the planets will accrete on order 1-2% of their total mass from primitive planetesimals scattered onto planet-crossing orbits during the formation of the planets. For an assumed value of 10% for the water mass fraction of the primitive planetesimals, this model delivers a total amount of water comparable to that estimated to be on the Earth today. While the radial distribution of the planetary masses and the dynamical excitation of their orbits are a good match to the observed system, we find that the last giant impact is typically earlier than 20 Myr, and a substantial amount of mass is accreted after that event. However, 5 of the 27 planets larger than half an Earth mass formed in all simulations do experience large late impacts and subsequent accretion consistent with the dating of the Moon-forming impact and the estimated amount of mass accreted by Earth following that event

The Compositional Structure of the Asteroid Belt

The past decade has brought major improvements in large-scale asteroid discovery and characterization with over half a million known asteroids and over 100,000 with some measurement of physical characterization. This explosion of data has allowed us to create a new global picture of the Main Asteroid Belt. Put in context with meteorite measurements and dynamical models, a new and more complete picture of Solar System evolution has emerged. The question has changed from "What was the original compositional gradient of the Asteroid Belt?" to "What was the original compositional gradient of small bodies across the entire Solar System?" No longer is the leading theory that two belts of planetesimals are primordial, but instead those belts were formed and sculpted through evolutionary processes after Solar System formation. This article reviews the advancements on the fronts of asteroid compositional characterization, meteorite measurements, and dynamical theories in the context of the heliocentric distribution of asteroid compositions seen in the Main Belt today. This chapter also reviews the major outstanding questions relating to asteroid compositions and distributions and summarizes the progress and current state of understanding of these questions to form the big picture of the formation and evolution of asteroids in the Main Belt. Finally, we briefly review the relevance of asteroids and their compositions in their greater context within our Solar System and beyond.Comment: Accepted chapter in Asteroids IV in the Space Science Series to be published Fall 201

Evaluating the neurophysiological evidence for predictive processing as a model of perception

For many years, the dominant theoretical framework guiding research into the neural origins of perceptual experience has been provided by hierarchical feedforward models, in which sensory inputs are passed through a series of increasingly complex feature detectors. However, the long‐standing orthodoxy of these accounts has recently been challenged by a radically different set of theories that contend that perception arises from a purely inferential process supported by two distinct classes of neurons: those that transmit predictions about sensory states and those that signal sensory information that deviates from those predictions. Although these predictive processing (PP) models have become increasingly influential in cognitive neuroscience, they are also criticized for lacking the empirical support to justify their status. This limited evidence base partly reflects the considerable methodological challenges that are presented when trying to test the unique predictions of these models. However, a confluence of technological and theoretical advances has prompted a recent surge in human and nonhuman neurophysiological research seeking to fill this empirical gap. Here, we will review this new research and evaluate the degree to which its findings support the key claims of PP

Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients

<p>Abstract</p> <p>Background</p> <p>Ischaemic preconditioning (IPC) has emerged as a method of reducing ischaemia-reperfusion injury. However, the complex mechanism through which IPC elicits this protection is not fully understood. The aim of this study was to investigate the genomic response induced by IPC in muscle biopsies taken from the operative leg of total knee arthroplasty patients in order to gain insight into the IPC mechanism.</p> <p>Methods</p> <p>Twenty patients, undergoing primary total knee arthroplasty, were randomly assigned to IPC (n = 10) and control (n = 10) groups. Patients in the IPC group received ischaemic preconditioning immediately prior to surgery. IPC was induced by three five-minute cycles of tourniquet insufflation interrupted by five-minute cycles of reperfusion. A muscle biopsy was taken from the operative knee of control and IPC-treated patients at the onset of surgery and, again, at one hour into surgery. The gene expression profile of muscle biopsies was determined using the Affymetrix Human U113 2.0 microarray system and validated using real-time polymerase chain reaction (RT-PCR). Measurements of C-reactive protein (CRP), erythrocyte sedimentation (ESR), white cell count (WCC), cytokines and haemoglobin were also made pre- and post-operatively.</p> <p>Results</p> <p>Microarray analysis revealed a significant increase in the expression of important oxidative stress defence genes, immediate early response genes and mitochondrial genes. Upregulation of pro-survival genes was also observed and correlated with a downregulation of pro-apoptotic gene expression. CRP, ESR, WCC, cytokine and haemoglobin levels were not significantly different between control and IPC patients.</p> <p>Conclusions</p> <p>The findings of this study suggest that IPC of the lower limb in total knee arthroplasty patients induces a protective genomic response, which results in increased expression of immediate early response genes, oxidative stress defence genes and pro-survival genes. These findings indicate that ischaemic preconditioning may be of potential benefit in knee arthroplasty and other musculoskeletal conditions.</p

Physical characterization and origin of binary near-Earth asteroid (175706) 1996 FG3

The near-Earth asteroid (NEA) (175706) 1996 FG3 is a particularly interesting spacecraft target: a binary asteroid with a low-DeltaV heliocentric orbit. The orbit of its satellite has provided valuable information about its mass density while its albedo and colors suggest it is primitive or part of the C-complex taxonomic grouping. We extend the physical characterization of this object with new observations of its emission at mid-Infrared (IR) wavelengths and with near-IR reflection spectroscopy. We derive an area-equivalent system diameter of 1.90 \pm 0.28 km (corresponding to approximate component diameters of 1.83 km and 0.51 km, respectively) and a geometric albedo of 0.039 \pm 0.012. 1996 FG3 was previously classified as a C-type asteroid, though the combined 0.4--2.5 micron spectrum with thermal correction indicates classification as B-type; both are consistent with the low measured albedo. Dynamical studies show that 1996 FG3 has most probably originated in the inner main asteroid belt. Recent work has suggested the inner Main Belt (142) Polana family as the possible origin of another low-DeltaV B-type NEA, (101955) 1999 RQ36. A similar origin for 1996 FG3 would require delivery by the overlapping Jupiter 7:2 and Mars 5:9 mean motion resonances rather than the nu-6 resonance, and we find this to be a low probability, but possible, origin.Comment: Published in Ap

When Less is More: Validating a Brief Scale to Rate Interprofessional Team Competencies

Background: There is a need for validated and easy-to-apply behavior-based tools for assessing interprofessional team competencies in clinical settings. The seven-item observerbased Modified McMaster-Ottawa scale was developed for the Team Objective Structured Clinical Encounter (TOSCE) to assess individual and team performance in interprofessional patient encounters. Objective: We aimed to improve scale usability for clinical settings by reducing item numbers while maintaining generalizability; and to explore the minimum number of observed cases required to achieve modest generalizability for giving feedback. Design: We administered a two-station TOSCE in April 2016 to 63 students split into 16 newly-formed teams, each consisting of four professions. The stations were of similar difficulty. We trained sixteen faculty to rate two teams each. We examined individual and team performance scores using generalizability (G) theory and principal component analysis (PCA). Results: The seven-item scale shows modest generalizability (.75) with individual scores. PCA revealed multicollinearity and singularity among scale items and we identified three potential items for removal. Reducing items for individual scores from seven to four (measuring Collaboration, Roles, Patient/Family-centeredness, and Conflict Management) changed scale generalizability from .75 to .73. Performance assessment with two cases is associated with reasonable generalizability (.73). Students in newly-formed interprofessional teams show a learning curve after one patient encounter. Team scores from a two-station TOSCE demonstrate low generalizability whether the scale consisted of four (.53) or seven items (.55). Conclusion: The four-item Modified McMaster-Ottawa scale for assessing individual performance in interprofessional teams retains the generalizability and validity of the seven-item scale. Observation of students in teams interacting with two different patients provides reasonably reliable ratings for giving feedback. The four-item scale has potential for assessing individual student skills and the impact of IPE curricula in clinical practice settings

The very large G-protein coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles

Sensory hair bundles in the inner ear are composed of stereocilia that can be interconnected by a variety of different link types, including tip links, horizontal top connectors, shaft connectors, and ankle links. The ankle link antigen is an epitope specifically associated with ankle links and the calycal processes of photoreceptors in chicks. Mass spectrometry and immunoblotting were used to identify this antigen as the avian ortholog of the very large G-protein-coupled receptor VLGR1, the product of the Usher syndrome USH2C (Mass1) locus. Like ankle links, Vlgr1 is expressed transiently around the base of developing hair bundles in mice. Ankle links fail to form in the cochleae of mice carrying a targeted mutation in Vlgr1 (Vlgr1/del7TM), and the bundles become disorganized just after birth. FM1-43 [N-(3-triethylammonium)propyl)-4-(4-(dibutylamino)styryl) pyridinium dibromide] dye loading and whole-cell recordings indicate mechanotransduction is impaired in cochlear, but not vestibular, hair cells of early postnatal Vlgr1/del7TM mutant mice. Auditory brainstem recordings and distortion product measurements indicate that these mice are severely deaf by the third week of life. Hair cells from the basal half of the cochlea are lost in 2-month-old Vlgr1/del7TM mice, and retinal function is mildly abnormal in aged mutants. Our results indicate that Vlgr1 is required for formation of the ankle link complex and the normal development of cochlear hair bundles

A low mass for Mars from Jupiter's early gas-driven migration

Jupiter and Saturn formed in a few million years (Haisch et al. 2001) from a gas-dominated protoplanetary disk, and were susceptible to gas-driven migration of their orbits on timescales of only ~100,000 years (Armitage 2007). Hydrodynamic simulations show that these giant planets can undergo a two-stage, inward-then-outward, migration (Masset & Snellgrove 2001, Morbidelli & Crida 2007, Pierens & Nelson 2008). The terrestrial planets finished accreting much later (Klein et al. 2009), and their characteristics, including Mars' small mass, are best reproduced by starting from a planetesimal disk with an outer edge at about one astronomical unit from the Sun (Wetherill 1978, Hansen 2009) (1 AU is the Earth-Sun distance). Here we report simulations of the early Solar System that show how the inward migration of Jupiter to 1.5 AU, and its subsequent outward migration, lead to a planetesimal disk truncated at 1 AU; the terrestrial planets then form from this disk over the next 30-50 million years, with an Earth/Mars mass ratio consistent with observations. Scattering by Jupiter initially empties but then repopulates the asteroid belt, with inner-belt bodies originating between 1 and 3 AU and outer-belt bodies originating between and beyond the giant planets. This explains the significant compositional differences across the asteroid belt. The key aspect missing from previous models of terrestrial planet formation is the substantial radial migration of the giant planets, which suggests that their behaviour is more similar to that inferred for extrasolar planets than previously thought.Comment: 12 pages, 4 figures + Supplementary Material 46 pages, 10 figure