5,574 research outputs found
Leg Sympathetic Response to Noxious Skin Stimuli is Similar in High and Low Level Human Spinal Cord Injury
Objective To determine if sympathetically mediated vasoconstriction in the lower extremities is injury level dependent. Although sympathetic responses have been measured in the limbs of people with high and low level SCI using blood flow measurements, including Doppler ultrasound and venous plethysmography, a direct comparison between injury levels has not been made. Methods Volunteers with chronic SCI were grouped according to injury level. Above T6: high level (HL, n = 7), and T6 and below: low level (LL, n = 6). All subjects had complete motor and sensory loss. Leg arterial flows were recorded by venous occlusion plethysmography, and continuous heart rate and mean arterial pressure (MAP) were measured. The conditioning stimulus consisted of transcutaneous stimulation to the arch of the contralateral foot. Results HL and LL subjects demonstrated a significant decrease in arterial conductance during stimulation with no significant difference found between groups. As expected, only group HL demonstrated a significant increase in MAP. Conclusions These results support our hypothesis that local (leg) sympathetic responses are similar for both high and low level SCI. Significance While low level SCI does not typically present with autonomic dysreflexia, bouts of increased reflex sympathetic activity could have ramifications for metabolism as well as renal and motor system functio
Leg Sympathetic Response to Noxious Skin Stimuli is Similar in High and Low Level Human Spinal Cord Injury
Objective To determine if sympathetically mediated vasoconstriction in the lower extremities is injury level dependent. Although sympathetic responses have been measured in the limbs of people with high and low level SCI using blood flow measurements, including Doppler ultrasound and venous plethysmography, a direct comparison between injury levels has not been made. Methods Volunteers with chronic SCI were grouped according to injury level. Above T6: high level (HL, n = 7), and T6 and below: low level (LL, n = 6). All subjects had complete motor and sensory loss. Leg arterial flows were recorded by venous occlusion plethysmography, and continuous heart rate and mean arterial pressure (MAP) were measured. The conditioning stimulus consisted of transcutaneous stimulation to the arch of the contralateral foot. Results HL and LL subjects demonstrated a significant decrease in arterial conductance during stimulation with no significant difference found between groups. As expected, only group HL demonstrated a significant increase in MAP. Conclusions These results support our hypothesis that local (leg) sympathetic responses are similar for both high and low level SCI. Significance While low level SCI does not typically present with autonomic dysreflexia, bouts of increased reflex sympathetic activity could have ramifications for metabolism as well as renal and motor system functio
SLIQ: Simple Linear Inequalities for Efficient Contig Scaffolding
Scaffolding is an important subproblem in "de novo" genome assembly in which
mate pair data are used to construct a linear sequence of contigs separated by
gaps. Here we present SLIQ, a set of simple linear inequalities derived from
the geometry of contigs on the line that can be used to predict the relative
positions and orientations of contigs from individual mate pair reads and thus
produce a contig digraph. The SLIQ inequalities can also filter out unreliable
mate pairs and can be used as a preprocessing step for any scaffolding
algorithm. We tested the SLIQ inequalities on five real data sets ranging in
complexity from simple bacterial genomes to complex mammalian genomes and
compared the results to the majority voting procedure used by many other
scaffolding algorithms. SLIQ predicted the relative positions and orientations
of the contigs with high accuracy in all cases and gave more accurate position
predictions than majority voting for complex genomes, in particular the human
genome. Finally, we present a simple scaffolding algorithm that produces linear
scaffolds given a contig digraph. We show that our algorithm is very efficient
compared to other scaffolding algorithms while maintaining high accuracy in
predicting both contig positions and orientations for real data sets.Comment: 16 pages, 6 figures, 7 table
Quantized Friction across Ionic Liquid Thin Films
Ionic liquids, salts in the liquid state under ambient conditions, are of
great interest as precision lubricants. Ionic liquids form layered structures
at surfaces, yet it is not clear how this nano-structure relates to their
lubrication properties. We measured the friction force between atomically
smooth solid surfaces across ionic liquid films of controlled thickness in
terms of the number of ion layers. Multiple friction-load regimes emerge, each
corresponding to a different number of ion layers in the film. In contrast to
molecular liquids, the friction coefficients differ for each layer due to their
varying composition
National trends in total hip arthroplasty for traumatic hip fractures: An analysis of a nationwide all-payer database.
BACKGROUND: Hemiarthroplasty (HA) has traditionally been the treatment of choice for elderly patients with displaced femoral neck fractures. Ideal treatment for younger, ambulatory patients is not as clear. Total hip arthroplasty (THA) has been increasingly utilized in this population however the factors associated with undergoing HA or THA have not been fully elucidated.
AIM: To examine what patient characteristics are associated with undergoing THA or HA. To determine if outcomes differ between the groups.
METHODS: We queried the Nationwide Inpatient Sample (NIS) for patients that underwent HA or THA for a femoral neck fracture between 2005 and 2014. The NIS comprises a large representative sample of inpatient hospitalizations in the United States. International Classifications of Disease, Ninth Edition (ICD-9) codes were used to identify patients in our sample. Demographic variables, hospital characteristics, payer status, medical comorbidities and mortality rates were compared between the two procedures. Multivariate logistic regression analysis was then performed to identify independent risk factors of treatment utilized.
RESULTS: Of the total 502060 patients who were treated for femoral neck fracture, 51568 (10.3%) underwent THA and the incidence of THA rose from 8.3% to 13.7%. Private insurance accounted for a higher percentage of THA than hemiarthroplasty. THA increased most in urban teaching hospitals relative to urban non-teaching hospitals. Mean length of stay (LOS) was longer for HA. The mean charges were less for HA, however charges decreased steadily for both groups. HA had a higher mortality rate, however, after adjusting for age and comorbidities HA was not an independent risk factor for mortality. Interestingly, private insurance was an independent predictor for treatment with THA.
CONLUSION: There has been an increase in the use of THA for the treatment of femoral neck fractures in the United States, most notably in urban hospitals. HA and THA are decreasing in total charges and LOS
The Compositional Structure of the Asteroid Belt
The past decade has brought major improvements in large-scale asteroid
discovery and characterization with over half a million known asteroids and
over 100,000 with some measurement of physical characterization. This explosion
of data has allowed us to create a new global picture of the Main Asteroid
Belt. Put in context with meteorite measurements and dynamical models, a new
and more complete picture of Solar System evolution has emerged. The question
has changed from "What was the original compositional gradient of the Asteroid
Belt?" to "What was the original compositional gradient of small bodies across
the entire Solar System?" No longer is the leading theory that two belts of
planetesimals are primordial, but instead those belts were formed and sculpted
through evolutionary processes after Solar System formation. This article
reviews the advancements on the fronts of asteroid compositional
characterization, meteorite measurements, and dynamical theories in the context
of the heliocentric distribution of asteroid compositions seen in the Main Belt
today. This chapter also reviews the major outstanding questions relating to
asteroid compositions and distributions and summarizes the progress and current
state of understanding of these questions to form the big picture of the
formation and evolution of asteroids in the Main Belt. Finally, we briefly
review the relevance of asteroids and their compositions in their greater
context within our Solar System and beyond.Comment: Accepted chapter in Asteroids IV in the Space Science Series to be
published Fall 201
Sixty-four-slice multidetector computed tomography: the future of ED cardiac care
Multidetector computed tomography (MDCT) imaging, a technological advance over traditional CT, is a promising possible alternative to cardiac catheterization for evaluating patients with chest pain in the emergency department (ED). In comparison with traditional CT, MDCT offers increased spatial and temporal resolution that allows reliable visualization of the coronary arteries. In addition, a triple scan, which includes evaluation for pulmonary embolism and thoracic aortic dissection, can be incorporated into a single study. This test will enable emergency physicians to rapidly evaluate patients for life-threatening illnesses and may allow safer and earlier discharges of many patients with chest pain in comparison with a traditional rule-out protocol. In this article, we will highlight the technological advances of MDCT imaging, review the literature on coronary angiography via MDCT, and discuss the future of this technology as it relates to the ED
Effects of Neuronic Shutter Observed in the EEG Alpha Rhythm
The posterior alpha (α) rhythm, seen in human electroencephalogram (EEG), is posited to originate from cycling inhibitory/excitatory states of visual relay cells in the thalamus. These cycling states are thought to lead to oscillating visual sensitivity levels termed the “neuronic shutter effect.” If true, perceptual performance should be predictable by observed α phase (of cycling inhibitory/excitatory states) relative to the timeline of afferentiation onto the visual cortex. Here, we tested this hypothesis by presenting contrast changes at near perceptual threshold intensity through closed eyelids to 20 participants (balanced for gender) during times of spontaneous α oscillations. To more accurately and rigorously test the shutter hypothesis than ever before, α rhythm phase and amplitude were calculated relative to each individual’s retina-to-primary visual cortex (V1) conduction delay, estimated from the individual’s C1 visual-evoked potential (VEP) latency. Our results show that stimulus observation rates (ORs) are greater at a trough than a peak of the posterior α rhythm when phase is measured at the individual’s conduction delay relative to stimulus onset. Specifically, the optimal phase for stimulus observation was found to be 272.41°, where ORs are 20.96% greater than the opposing phase of 92.41°. The perception-phase relationship is modulated by α rhythm amplitude and is not observed at lower amplitude oscillations. Collectively, these results provide support to the “neuronic shutter” hypothesis and demonstrate a phase and timing relationship consistent with the theory that cycling excitability in the thalamic relay cells underly posterior α oscillations
Exploring the nuclear pion dispersion relation through the anomalous coupling of photon to photon and neutral pion
We investigate the possibility of measuring the pion dispersion relation in
nuclear matter through the anomalous coupling in the reaction \gamma - \gamma'
\pi_0. It is shown that this reaction permits the study of pionic modes for
space-like momenta. If the pion is softened in nuclear matter due to mixing
with the delta-hole state, significant strength for this reaction is expected
to move into the space-like region. Competing background processes are
evaluated, and it is concluded that useful insight can be obtained
experimentally, but only through a difficult exclusive measurement
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