Three-Qubit Gate Realization Using Single Quantum Particle

Using virtual spin formalism it is shown that a quantum particle with eight energy levels can store three qubits. The formalism allows to realize a universal set of quantum gates. Feasible formalism implementation is suggested which uses nuclear spin-7/2 as a storage medium and radio frequency pulses as the gates. One pulse realization of all universal gates has been found, including three-qubit Toffoli gate.Comment: LaTeX, 6 pages, no figures; Submitted to "Pis'ma v Zh. Eksp. Teor. Fiz.

Particle acceleration due to shocks in the interplanetary field: High time resolution data and simulation results

Data were examined from two experiments aboard the Explorer 50 (IMP 8) spacecraft. The Johns Hopkins University/Applied Lab Charged Particle Measurement Experiment (CPME) provides 10.12 second resolution ion and electron count rates as well as 5.5 minute or longer averages of the same, with data sampled in the ecliptic plane. The high time resolution of the data allows for an explicit, point by point, merging of the magnetic field and particle data and thus a close examination of the pre- and post-shock conditions and particle fluxes associated with large angle oblique shocks in the interplanetary field. A computer simulation has been developed wherein sample particle trajectories, taken from observed fluxes, are allowed to interact with a planar shock either forward or backward in time. One event, the 1974 Day 312 shock, is examined in detail

Challenges and Opportunities for Spark Plasma Sintering: A Key Technology for a New Generation of Materials

This is an open access article distributed under the terms of the Creative Commons Attribution License.-- et al.Peer reviewe

Randomized study exploring the combination of radiotherapy with two types of acupuncture treatment (ROSETTA): study protocol for a randomized controlled trial.

Adverse effects such as fatigue, pain, erythema, nausea and vomiting are commonly known in patients undergoing irradiation (RT) alone or in combination with chemotherapy (RCHT). Patients suffering from these symptoms are limited in their daily life and their quality of life (QOL) is often reduced. As addressed in several trials, acupuncture can cause amelioration of these specific disorders. Especially for pain symptoms, several groups have shown efficacy of acupuncture. To what extent the difference between traditional acupuncture (verum acupuncture) and false acupuncture (sham acupuncture) is in reducing side effects and improvement of QOL is not clear. ROSETTA is a prospective randomized phase II trial (version 1.0) to examine the efficacy of traditional acupuncture in patients with RT-related side effects. In the experimental (verum) arm (n = 37) an experienced acupuncture-trained person will treat dedicated acupuncture points. In the control (sham) arm (n = 37) sham acupuncture will be performed to provide a blinded comparison of results. This is the first randomized prospective trial to evaluate the effect of traditional acupuncture on RT-related side effects such as fatigue and QOL. ClinicalTrials.gov, NCT02674646 . Registered on 8 December 2015

Anti-intruder port protection “MAC (Magnetic ACoustic) System”: advances in the magnetic component performance

In the following, we report the advances made in the development of a magnetic component for peripheral monitoring of port environments for anti-intruder systems. The project was initiated by the Office of Research and Development, COMFORDRAG, Italian Navy, in 2004, with the aim of improving the detection performance of current acoustic-based anti-intruder systems, in the vicinity of quays or the seabed or in acoustic-shadow zones behind natural or artificial objects. In the five-year period from 2004 to 2008, the system has been subjected to detection-performance tests in experiments involving divers equipped with air tanks and rebreather kits in real port environments and, at the same time, the associated signal processing has been subjected to development, to enhance detection performance. In tests involving simulated diver attacks against a vessel moored alongside a quay in the port of La Spezia, the system has been proved particularly effective by detecting 9 divers out of 9. The processing of the magnetic signal has been enhanced by implementing an amplitude threshold, as a means of filtering the passive energy components, termed Passive Energy Cutting (PEC), that is, the elimination of components that comprise no useful information regarding diver transits. The use of PEC boosts the reliability of the system in terms of detection versus false alarm rate, as evidenced by the comparison of the ROC curves for the system with and without PEC

The clinical and cost-effectiveness of a Victim Improvement Package (VIP) for the reduction of chronic symptoms of depression or anxiety in older victims of common crime (the VIP trial): study protocol for a randomised controlled trial.

BACKGROUND: Older people are vulnerable to sustained high levels of psychosocial distress following a crime. A cognitive behavioural therapy (CBT)-informed psychological therapy, the Victim Improvement Package (VIP) may aid recovery. The VIP trial aims to test the clinical and cost-effectiveness of the VIP for alleviating depressive and anxiety symptoms in older victims of crime. METHODS/DESIGN: People aged 65 years or more who report being a victim of crime will be screened by Metropolitan Police Service Safer Neighbourhood Teams within a month of the crime for distress using the Patient Health Questionnaire-2 and the Generalised Anxiety Disorder-2. Those who screen positive will be signposted to their GP for assistance, and re-screened at 3 months. Participants who screen positive for depression and/or anxiety at re-screening are randomised to a CBT informed VIP added to treatment as usual (TAU) compared to TAU alone. The intervention consists of 10 individual 1-h sessions, delivered weekly by therapists from the mental health charity Mind. The primary outcome measure is the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI), used as a composite measure, assessed at 6 months after the crime (post therapy) with a 9-month post-crime follow-up. Secondary outcome measures include the EQ-5D, and a modified Client Service Receipt Inventory. A total of 226 participants will be randomised VIP:TAU with a ratio 1:1, in order to detect a standardised difference of at least 0.5 between groups, using a mixed-effects linear-regression model with 90% power and a 5% significance level (adjusting for therapist clustering and potential drop-out). A cost-effectiveness analysis will incorporate intervention costs to compare overall health care costs and quality of life years between treatment arms. An embedded study will examine the impact of past trauma and engagement in safety behaviours and distress on the main outcomes. DISCUSSION: This trial should provide data on the clinical and cost-effectiveness of a CBT-informed psychological therapy for older victims of crime with anxiety and/or depressive symptoms and should demonstrate a model of integrated cross-agency working. Our findings should provide evidence for policy-makers, commissioners and clinicians responding to the needs of older victims of crime. TRIAL REGISTRATION: International Standard Randomised Controlled Trials Number, ID: ISRCTN16929670. Registered on 3 August 2016

Profiling the vendors of COVID‐19 related product on the Darknet: An observational study

Background In a time of unprecedented global change, the COVID-19 pandemic has led to a surge in demand of COVID-19 vaccines and related certifications. Mainly due to supply shortages, counterfeit vaccines, fake documentation, and alleged cures to illegal portfolios, have been offered on darkweb marketplaces (DWMs) with important public health consequences. We aimed to profile key DWMs and vendors by presenting some in-depth case studies. Methods A non-systematic search for COVID-19 products was performed across 118 DWMs. Levels of activity, credibility, content, COVID-19 product listings, privacy protocols were among the features retrieved. Open web fora and other open web sources were also considered for further analysis of both functional and non functional DWMs. Collected data refers to the period between January 2020 and October 2021. Results A total of 42 relevant listings sold by 24 vendors across eight DWMs were identified. Four of these markets were active and well-established at the time of the study with good levels of credibility. COVID-19 products were listed alongside other marketplace content. Vendors had a trusted profile, communicated in English language and accepted payments in cryptocurrencies (Monero or Bitcoin). Their geographical location included the USA, Asia and Europe. While COVID-19 related goods were mostly available for regional supply, other listings were also shipped worldwide. Interpretation Findings emerging from this study rise important questions about the health safety of certain DWMs activities and encourage the development of targeted interventions to overcome such new and rapidly expanding public health threats. Funding CovSaf, National Research centre on Privacy, Harm Reduction and Adversarial Influence Online (REPHRAIN), Commonwealth Fund