A Simulation of High Latitude F-Layer Instabilities in the Presence of Magnetosphere-Ionosphere Coupling

A magnetic-field-line-integrated model of plasma interchange instabilities is developed for the high latitude ionosphere including magnetospheric coupling effects. We show that primary magnetosphere-ionosphere coupling effect is to incorporate the inertia of the magnetospheric plasma in the analysis. As a specific example, we present the first simulation of the E x B instability in the inertial regime, i.e., nu sub i omega where nu sub i is the ion-neutral collision frequency and omega is the wave frequency. We find that the inertial E x B instability develops in a fundamentally different manner than in the collisional case ni sub i omega. Our results show that striations produced in the inertial regime are spread and retarded by ion inertial effects, and result in more isotropic irregularities than those seen in the collisional case

Mode resolved density of atmospheric aerosol particles

In this study, we investigate the mode resolved density of ultrafine atmospheric particles measured in boreal forest environment. The method used here enables us to find the distinct density information for each mode in atmospheric fine particle population: the density values for nucleation, Aitken, and accumulation mode particles are presented. The experimental data was gained during 2 May 2005–19 May 2005 at the boreal forest measurement station "SMEAR II" in Hyytiälä, Southern Finland. The density values for accumulation mode varied from 1.1 to 2 g/cm<sup>3</sup> (average 1.5 g/cm<sup>3</sup>) and for Aitken mode from 0.4 to 2 g/cm<sup>3</sup> (average 0.97 g/cm<sup>3</sup>). As an overall trend during the two weeks campaign, the density value of Aitken mode was seen to gradually increase. With the present method, the time dependent behaviour of the particle density can be investigated in the time scale of 10 min. This allows us to follow the density evolution of the nucleation mode particles during the particle growth process following the nucleation burst. The density of nucleation mode particles decreased during the growth process. The density values for 15 nm particles were 1.2–1.5 g/cm<sup>3</sup> and for grown 30 nm particles 0.5–1 g/cm<sup>3</sup>. These values are consistent with the present knowledge that the condensing species are semi-volatile organics, emitted from the boreal forest

Promoting Development in Shared River Basins : Case Studies from International Experience

Transboundary freshwater systems create inevitable linkages and interdependencies between countries. The use of shared water resources by one country will, in most cases, impact other countries sharing the same system. At the same time, coordination among countries in the development of transboundary basins can yield greater benefits than would be available to individual countries pursuing individual development. UN Sustainable Development Goal 6 Target 5 recognizes this potential, calling on the world community to implement integrated water resources management at all levels, ‘including through transboundary cooperation as appropriate’. With a growing number of basins in which water use and demand permanently or temporarily exceeds the amount of renewable water available, and uncertainty from climate change, SDG Target 6.5 becomes increasingly relevant to development interventions designed to secure availability of supplies and create resilience. This is a companion document to the study "Promoting Development in Shared River Basins: Tools for Enhancing Transboundary Basin Management," which aims to contribute to relevant knowledge for achieving SDG Target 6.5. It presents six case studies from international experience on coordinated management in transboundary basins: Kura-Araks Basin; Columbia Basin; Chu and Talas Basins; Vuoksi Basin; Douro Basin; and Rhône Basin. The case studies demonstrate real-world application of selecting appropriate tools for individual transboundary situations along a three-stage process of coordinated basin development, which is detailed in the main study

Cutting productivity of windfalls in Finland

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Хромоколоноскопия как метод улучшения эндоскопического изображения

КОЛОНОСКОПИЯЭНДОСКОПИЯхромоскопияПОЛИПЫМЕТИЛЕНОВЫЙ СИНИ

EC-Earth3-AerChem: A global climate model with interactive aerosols and atmospheric chemistry participating in CMIP6

This paper documents the global climate model EC-Earth3-AerChem, one of the members of the EC-Earth3 family of models participating in the Coupled Model Intercomparison Project Phase 6 (CMIP6). EC-Earth3-AerChem has interactive aerosols and atmospheric chemistry and contributes to the Aerosols and Chemistry Model Intercomparison Project (AerChemMIP). In this paper, we give an overview of the model, describe in detail how it differs from the other EC-Earth3 configurations, and outline the new features compared with the previously documented version of the model (EC-Earth 2.4). We explain how the model was tuned and spun up under preindustrial conditions and characterize the model's general performance on the basis of a selection of coupled simulations conducted for CMIP6. The net energy imbalance at the top of the atmosphere in the preindustrial control simulation is on average -0.09 W m-2 with a standard deviation due to interannual variability of 0.25 W m-2, showing no significant drift. The global surface air temperature in the simulation is on average 14.08 ∼ C with an interannual standard deviation of 0.17 ∼ C, exhibiting a small drift of 0.015 ± 0.005 ∼ C per century. The model's effective equilibrium climate sensitivity is estimated at 3.9 ∼ C, and its transient climate response is estimated at 2.1 ∼ C. The CMIP6 historical simulation displays spurious interdecadal variability in Northern Hemisphere temperatures, resulting in a large spread across ensemble members and a tendency to underestimate observed annual surface temperature anomalies from the early 20th century onwards. The observed warming of the Southern Hemisphere is well reproduced by the model. Compared with the ECMWF (European Centre for Medium-Range Weather Forecasts) Reanalysis version 5 (ERA5), the surface air temperature climatology for 1995-2014 has an average bias of -0.86 ± 0.05 ∼ C with a standard deviation across ensemble members of 0.35 ∼ C in the Northern Hemisphere and 1.29 ± 0.02 ∼ C with a corresponding standard deviation of 0.05 ∼ C in the Southern Hemisphere. The Southern Hemisphere warm bias is largely caused by errors in shortwave cloud radiative effects over the Southern Ocean, a deficiency of many climate models. Changes in the emissions of near-term climate forcers (NTCFs) have significant effects on the global climate from the second half of the 20th century onwards. For the SSP3-7.0 Shared Socioeconomic Pathway, the model gives a global warming at the end of the 21st century (2091-2100) of 4.9 ∼ C above the preindustrial mean. A 0.5 ∼ C stronger warming is obtained for the AerChemMIP scenario with reduced emissions of NTCFs. With concurrent reductions of future methane concentrations, the warming is projected to be reduced by 0.5 ∼ C

Future changes in Mekong River hydrology: impact of climate change and reservoir operation on discharge

The transboundary Mekong River is facing two ongoing changes that are expected to significantly impact its hydrology and the characteristics of its exceptional flood pulse. The rapid economic development of the riparian countries has led to massive plans for hydropower construction, and projected climate change is expected to alter the monsoon patterns and increase temperature in the basin. The aim of this study is to assess the cumulative impact of these factors on the hydrology of the Mekong within next 20–30 yr. We downscaled the output of five general circulation models (GCMs) that were found to perform well in the Mekong region. For the simulation of reservoir operation, we used an optimisation approach to estimate the operation of multiple reservoirs, including both existing and planned hydropower reservoirs. For the hydrological assessment, we used a distributed hydrological model, VMod, with a grid resolution of 5 km × 5 km. In terms of climate change's impact on hydrology, we found a high variation in the discharge results depending on which of the GCMs is used as input. The simulated change in discharge at Kratie (Cambodia) between the baseline (1982–1992) and projected time period (2032–2042) ranges from −11% to +15% for the wet season and −10% to +13% for the dry season. Our analysis also shows that the changes in discharge due to planned reservoir operations are clearly larger than those simulated due to climate change: 25–160% higher dry season flows and 5–24% lower flood peaks in Kratie. The projected cumulative impacts follow rather closely the reservoir operation impacts, with an envelope around them induced by the different GCMs. Our results thus indicate that within the coming 20–30 yr, the operation of planned hydropower reservoirs is likely to have a larger impact on the Mekong hydrograph than the impacts of climate change, particularly during the dry season. On the other hand, climate change will increase the uncertainty of the estimated reservoir operation impacts: our results indicate that even the direction of the flow-related changes induced by climate change is partly unclear. Consequently, both dam planners and dam operators should pay closer attention to the cumulative impacts of climate change and reservoir operation on aquatic ecosystems, including the multibillion-dollar Mekong fisheries

Adjustment of Insulin Pump Settings in Type 1 Diabetes Management: Advisor Pro Device Compared to Physicians’ Recommendations

Aims: To compare insulin dose adjustments made by physicians to those made by an artificial intelligence-based decision support system, the Advisor Pro, in people with type 1 diabetes (T1D) using an insulin pump and self-monitoring blood glucose (SMBG). Methods: This was a multinational, non-interventional study surveying 17 physicians from 11 countries. Each physician was asked to provide insulin dose adjustments for the settings of the pump including basal rate, carbohydrate-to-insulin ratios (CRs), and correction factors (CFs) for 15 data sets of pumps and SMBG of people with T1D (mean age 18.4 ± 4.8 years; eight females; mean glycated hemoglobin 8.2% ± 1.4% [66 ± 11mmol/mol]). The recommendations were compared among the physicians and between the physicians and the Advisor Pro. The study endpoint was the percentage of comparison points for which there was an agreement on the direction of insulin dose adjustments. Results: The percentage (mean ± SD) of agreement among the physicians on the direction of insulin pump dose adjustments was 51.8% ± 9.2%, 54.2% ± 6.4%, and 49.8% ± 11.6% for the basal, CR, and CF, respectively. The automated recommendations of the Advisor Pro on the direction of insulin dose adjustments were comparable)49.5% ± 6.4%, 55.3% ± 8.7%, and 47.6% ± 14.4% for the basal rate, CR, and CF, respectively(and noninferior to those provided by physicians. The mean absolute difference in magnitude of change between physicians was 17.1% ± 13.1%, 14.6% ± 8.4%, and 23.9% ± 18.6% for the basal, CR, and CF, respectively, and comparable to the Advisor Pro 11.7% ± 9.7%, 10.1% ± 4.5%, and 25.5% ± 19.5%, respectively, significant for basal and CR. Conclusions: Considerable differences in the recommendations for changes in insulin dosing were observed among physicians. Since automated recommendations by the Advisor Pro were similar to those given by physicians, it could be considered a useful tool to manage T1D

Analogue peptides for the immunotherapy of human acute myeloid leukemia

Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the immune system as the tumor develops, leading to tolerance or some degree of host tumor cell destruction. To try to break tolerance against self-antigens, one of the methods employed has been to modify peptides at the anchor residues to enhance their ability to bind major histocompatibility complex molecules, extending their exposure to the T-cell receptor. These modified or analogue peptides have been investigated as stimulators of the immune system in patients with different cancers with variable but sometimes notable success. In this review we describe the background and recent developments in the use of analogue peptides for the immunotherapy of acute myeloid leukemia describing knowledge useful for the application of analogue peptide treatments for other malignancies

Metabolic investigations prevent liver transplantation in two young children with citrullinemia type I

Acute liver failure may be caused by a variety of disorders including inborn errors of metabolism. In those cases, rapid metabolic investigations and adequate treatment may avoid the need for liver transplantation. We report two patients who presented with acute liver failure and were referred to our center for liver transplantation work-up. Urgent metabolic investigations revealed citrullinemia type I. Treatment for citrullinemia type I avoided the need for liver transplantation. Acute liver failure as a presentation of citrullinemia type I has not previously been reported in young children. Although acute liver failure has occasionally been described in other urea cycle disorders, these disorders may be underestimated as a cause. Timely diagnosis and treatment of these disorders may avoid liver transplantation and improve clinical outcome. Therefore, urea cycle disorders should be included in the differential diagnosis in young children presenting with acute liver failure