Body composition in young female eating-disorder patients with severe weight loss and controls: evidence from the four-component model and evaluation of DXA

BACKGROUND/OBJECTIVES: Whether fat-free mass (FFM) and its components are depleted in eating-disorder (ED) patients is uncertain. Dual energy X-ray absorptiometry (DXA) is widely used to assess body composition in pediatric ED patients; however, its accuracy in underweight populations remains unknown. We aimed (1) to assess body composition of young females with ED involving substantial weight loss, relative to healthy controls using the four-component (4C) model, and (2) to explore the validity of DXA body composition assessment in ED patients. SUBJECTS/METHODS: Body composition of 13 females with ED and 117 controls, aged 10-18 years, was investigated using the 4C model. Accuracy of DXA for estimation of FFM and fat mass (FM) was tested using the approach of Bland and Altman. RESULTS: Adjusting for age, height and pubertal stage, ED patients had significantly lower whole-body FM, FFM, protein mass (PM) and mineral mass (MM) compared with controls. Trunk and limb FM and limb lean soft tissue were significantly lower in ED patients. However, no significant difference in the hydration of FFM was detected. Compared with the 4C model, DXA overestimated FM by 5 +/- 36% and underestimated FFM by 1 +/- 9% in ED patients. CONCLUSION: Our study confirms that ED patients are depleted not only in FM but also in FFM, PM and MM. DXA has limitations for estimating body composition in individual young female ED patients

Impact on parents of HLA-DQ2/DQ8 genotyping in healthy children from coeliac families

Due to the association of coeliac disease and HLA-specificities DQ2 and DQ8, HLA-typing can be used for risk determination of the disease. This study was designed to evaluate the knowledge of parents from coeliac families regarding HLA-typing and the impact of HLA-typing on the perception of the health of their children. A structured questionnaire was sent to the Dutch, Spanish and German parents participating with their child in the European PreventCD study on disease prevention in high-risk families, addressing parents' understanding of and attitude towards HLA-typing, distress related to HLA-typing and perceived health and health-related quality of life of their children. Sixty-eight percent of parents of 515 children returned the questionnaires, with 85% of children being DQ2/DQ8 positive. The majority of all parents answered the questions on knowledge correctly. Forty-eight percent of parents of DQ2/DQ8-negative children thought their child could develop coeliac disease. More distress was reported by parents of DQ2/DQ8-positive children (

Composição corporal em crianças de sete a 10 anos de idade, de alto nível socioeconômico Body composition in seven-to-ten-year old children of high socioeconomic status

O objetivo deste estudo foi analisar a composição corporal de crianças de sete a 10 anos de idade, de alto nível socioeconômico. Para tanto, 511 crianças (274 meninos e 237 meninas) foram submetidas a medidas antropométricas de massa corporal, estatura e espessuras de dobras cutâneas tricipital (TR) e subescapular (SE). Com base nessas informações, foram determinados: gordura corporal relativa (% Gordura), massa corporal magra (MCM), distribuição da gordura corporal (DGC) e o somatório da espessura das dobras cutâneas TR e SE (&#931;EDC). Anova two-way foi utilizada para as comparações entre os sexos e os diferentes grupos etários, seguida pelo teste post hoc de Scheffé quando P < 0,05. Para a classificação das crianças, de acordo com as categorias de adiposidade corporal, foi utilizada distribuição de freqüência. O teste de comparação entre proporções foi adotado para verificar as diferenças entre os sexos, em cada categoria (P < 0,05). Diferenças significantes entre os sexos (P < 0,05) foram verificadas na dobra TR (meninas > meninos) e na MCM (meninos > meninas). Efeito significante da idade foi identificado em todas as variáveis analisadas, exceto na DGC, com os valores mais elevados sendo encontrados no grupo etário de 10 anos. Um percentual elevado, tanto de meninos quanto de meninas, apresentou índice de adiposidade alto, com superioridade para os meninos (28% vs. 14%, P < 0,01). Por outro lado, um contingente maior de meninas apresentou concentrações de gordura corporal relativa abaixo dos pontos de corte desejáveis (15% vs. 3%, P < 0,01). Os valores de adiposidade corporal encontrados no presente estudo sugerem que um percentual elevado de crianças, de ambos os sexos, já apresenta importantes fatores de risco à saúde, em idades precoces.<br>The objective of this study was to analyze the body composition of seven to 10 year-old children of high socioeconomic status. Therefore, 511 children (274 boys and 237 girls) were submitted to body mass, height and triceps (TR) and subscapular (SE) skinfolds thickness anthropometric measurement. Based on this information, the following topics were determined: relative body fat (% Fat), lean body mass (LBM), body fat distribution (BFD) and sum of the thickness of the TR and SE skinfolds (£TSF). Two-way ANOVA was used for comparisons between gender and the different age groups, followed by the Scheffé post hoc test when P < 0.05. For the children classification according to the categories of body adiposity, frequency distribution was used. A test of comparison between ratios was adopted to verify the differences between gender in each category (P < 0.05). Significant differences between gender (P < 0.05) were verified in TR skinfold (girls > boys) and in LBM (boys > girls). Significant age effect was identified in all analyzed variables, except for DBF, with the highest values having been found in the 10 year-old group. A high percentage both for boys and girls presented high adiposity index, with superiority for boys (28% vs. 14%, P < 0.01). On the other hand, a larger number of girls presented relative body fat concentrations below the desirable cutting points (15% vs. 3%, P < 0.01). The values of body adiposity found in the present study suggest that a high percentage of children from both gender already present important health risk factors at early ages