Development of a decision support tool to facilitate primary care management of patients with abnormal liver function tests without clinically apparent liver disease [HTA03/38/02]. Abnormal Liver Function Investigations Evaluation (ALFIE)

Liver function tests (LFTs) are routinely performed in primary care, and are often the gateway to further invasive and/or expensive investigations. Little is known of the consequences in people with an initial abnormal liver function (ALF) test in primary care and with no obvious liver disease. Further investigations may be dangerous for the patient and expensive for Health Services. The aims of this study are to determine the natural history of abnormalities in LFTs before overt liver disease presents in the population and identify those who require minimal further investigations with the potential for reduction in NHS costs

Academic Freedom, Political Interference and Political Accountability: The Hong Kong Experience

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A set of invariant quality factors measuring the deviation from the Kerr metric

Published online: 27 March 2013 ; Author´s personal copyA number of scalar invariant characterizations of the Kerr solution are presented. These characterizations come in the form of quality factors defined in stationary space-times. A quality factor is a scalar quantity varying in the interval [0, 1] with the value 1 being attained if and only if the space-time is locally isometric to the Kerr solution. No knowledge of the Kerr solution is required to compute these quality factors. A number of different possibilities arise depending on whether the space-time is Ricci-flat and asymptotically flat, just Ricci-flat, or Ricci non-flat. In each situation a number of quality factors are constructed and analysed. The relevance of these quality factors is clear in any situation where one seeks a rigorous formulation of the statement that a space-time is “close” to the Kerr solution, such as: its non-linear stability problem, the asymptotic settlement of a radiating isolated system undergoing gravitational collapse, or in the formulation of some uniqueness results.Junta de Andalucía, Universidad del País Vasco, Centro de Matemática da Universidade do Minho e Fundação para a Ciência e a Tecnologia (FCT