Towards energetically viable asymmetric deprotonations : selectivity at more elevated temperatures with C2-symmetric magnesium bisamides

A novel chiral magnesium bisamide has enabled the development of effective asymmetric deprotonation protocols at substantially more elevated temperatures. This new, structurally simple, C2-symmetric magnesium complex displays excellent levels of asymmetric efficiency and energy reduction in the synthesis of enantioenriched enol silane

Perceived environmental factors related to adults’ leisure-time physical activity : findings from Europe, Australia and the USA

This journal suppl. entitled: Be Avtive 2012Session 204B - Environments and physical activity: Adults: paper no. 524INTRODUCTION: A growing body of evidence shows that objective and perceived built environment factors are positively associated with physical activity in adults. However, built environment correlates are behavior-specific and the factors associated with leisure-time physical activity are less understood than those associated with active transportation. Furthermore, most previous studies of associations of built environment attributes with physical activity have been conducted in single countries. Limited within-country variability in environmental attributes and physical activity levels can potentially contribute to an underestimation of the strength of the associations. Therefore, the purpose of this study was to examine the strength, direction and shape of the associations of neighborhood environmental perceptions with recreational walking and leisure-time moderate-to-vigorous physical activity, using pooled data from four study sites (Baltimore [USA], Seattle [USA], Adelaide [Australia] and Ghent [Belgium]) in culturally- and environmentally-diverse countries. Moreover, site- and gender-specificity of the associations were examined. METHODS: Data from the four study sites were pooled. In total, 6,014 adults (20–65 years, 55.7% women) were randomly recruited in high-/low-walkable and high-/low-income neighborhoods in the four sites. All participants completed the Neighborhood Environmental Walkability Scale (environmental perceptions) and the International Physical Activity Questionnaire. General additive mixed models were used to estimate the strength and shape of the associations between environmental perceptions and leisure-time activity (walking and moderate-to-vigorous physical activity). RESULTS: Perceived residential density, aesthetics and reporting few barriers to physical activity in the neighborhood were included in a ‘recreational walking-friendliness’ index. This index was linearly positively related to recreational walking in all study sites except Ghent. No gender-differences were observed. The ‘leisure-time activity friendliness’ index consisted of perceived residential density, proximity to recreation facilities, aesthetics and perceiving few barriers in the neighborhood. This index had a positive linear association with leisure-time moderate-to-vigorous physical activity that was significant in all sites but Ghent. Again, no gender-differences in the associations were found. DISCUSSION: Similar environmental attributes were related to both outcome measures in men and women, but the present findings were clearly site-specific, imposing possible challenges for built environment recommendations. In Europe, interventions to promote leisure-time activity may need to target promotion of existing opportunities rather than built environment improvements. In the USA and Australia, a focus on the factors identified in this study, may be of most relevance for promoting leisure-time physical activity

Analysis of LIN28A in early human ovary development and as a candidate gene for primary ovarian insufficiency

Lin28 proteins are emerging as important regulators of microRNAs in endocrine systems. Lin28a regulates primordial germ cell development and puberty timing in mice, whereas the related protein LIN28B is associated with age at menarche in genome-wide association studies in humans. Here, we studied expression of LIN28A and LIN28B in early human gonad development. LIN28A increased in the developing ovary between 6 and 9 weeks post conception, but not in the developing testis. Immunohistochemistry demonstrated LIN28A in peripheral germ cells. LIN28B was expressed at lower levels in both tissues and did not increase with time. As disruption of Lin28a affects germ cell development in mice, LIN28A was considered a candidate gene for primary ovarian insufficiency (POI) in humans. However, no significant changes were found in 50 women studied. These findings show LIN28A is strongly expressed in germ cells during early human ovary development, but disruption of LIN28A is not a common cause of POI

Radio observations of a few giant sources

We present multifrequency observations with the Giant Metrewave Radio Telescope (GMRT) and the Very Large Array (VLA) of a sample of seventeen largely giant radio sources (GRSs). These observations have either helped clarify the radio structures or provided new information at a different frequency. The broad line radio galaxy, J0313+413, has an asymmetric, curved radio jet and a variable radio core, consistent with a moderate angle of inclination to the line of sight. We attempt to identify steep spectrum radio cores (SSCs), which may be a sign of recurrent activity, and find four candidates. If confirmed, this would indicate a trend for SSCs to occur preferentially in GRSs. From the structure and integrated spectra of the sources we suggest that the lobes of emission in J0139+399 and J0200+408 may be due to an earlier cycle of nuclear activity. We find that inverse-Compton losses with the cosmic microwave background radiation dominate over synchrotron radiative losses in the lobes of all the sources, consistent with earlier studies. We also show that prominence of the bridge emission decreases with increasing redshift, possibly due to inverse-Compton losses. This could affect the appearance and identification of GRSs at large redshifts.Comment: 11 pages, 2 figures (Figure 1 shows the images of 17 sources), 4 tables. accepted for publication in Monthly Notice

Education as a Predictor of Chronic Periodontitis: A Systematic Review with Meta-Analysis Population-Based Studies

The impact of socioeconomic inequalities on health is well-documented. Despite the links of periodontal disease with cardiovascular diseases, adverse pregnancy outcomes and diabetes, no meta-analysis of socioeconomic variations in periodontal disease exists. This meta-analytic review was conducted to determine the extent to which education attainment influences risk of periodontitis in adults aged 35+ years in the general population.The authors searched studies published until November 2010 using EMBASE and MEDLINE databases. References listed were then scrutinised, our own files were checked, and, finally, we contacted experts in the field. The authors included only general population-based studies conducted in adults aged 35 years and more. All articles were blind reviewed by two investigators. In the case of disagreement, a third investigator arbitrated. Using PRISMA statement, two reviewers independently extracted papers of interest.Relative to the higher education group, people with low education attainment experience a greater risk of periodontitis (OR: 1.86 [1.66–2.10]; p<0.00001). The association was partially attenuated after adjustment for covariates (OR: 1.55 [1.30–1.86]; p<0.00001). Sensitivity analyses showed that methods used to assess periodontitis, definition of cases, study country and categorization of education are largely responsible for the heterogeneity between studies. No significant bias of publication was shown using both the Egger (p = 0.16) and rank correlation tests (p = 0.35).In the studies reviewed, low educational attainment was associated with an increased risk of periodontitis. Although this evidence should be cautiously interpreted due to methodological problems in selected studies, efforts to eliminate educational inequalities in periodontitis should focus on early life interventions

Do you get what you pay for? Sales incentives and implications for motivation and changes in turnover intention and work effort

This study investigated relations between pay-for-performance incentives designed to vary in instrumentality (annual pay-for-performance, quarterly pay-for-performance, and base pay level) and employee outcomes (self-reported work effort and turnover intention) in a longitudinal study spanning more than 2 years. After controlling for perceived instrumentality, merit pay increase, and the initial values of the dependent variables, the amount of base pay was positively related to work effort and negatively related to turnover intention, where both relationships were mediated by autonomous motivation. The amounts of quarterly and annual pay-for-performance were both positively related to controlled motivation, but were differently related to the dependent variables due to different relations with autonomous motivation

Size Doesn't Matter: Towards a More Inclusive Philosophy of Biology

notes: As the primary author, O’Malley drafted the paper, and gathered and analysed data (scientific papers and talks). Conceptual analysis was conducted by both authors.publication-status: Publishedtypes: ArticlePhilosophers of biology, along with everyone else, generally perceive life to fall into two broad categories, the microbes and macrobes, and then pay most of their attention to the latter. ‘Macrobe’ is the word we propose for larger life forms, and we use it as part of an argument for microbial equality. We suggest that taking more notice of microbes – the dominant life form on the planet, both now and throughout evolutionary history – will transform some of the philosophy of biology’s standard ideas on ontology, evolution, taxonomy and biodiversity. We set out a number of recent developments in microbiology – including biofilm formation, chemotaxis, quorum sensing and gene transfer – that highlight microbial capacities for cooperation and communication and break down conventional thinking that microbes are solely or primarily single-celled organisms. These insights also bring new perspectives to the levels of selection debate, as well as to discussions of the evolution and nature of multicellularity, and to neo-Darwinian understandings of evolutionary mechanisms. We show how these revisions lead to further complications for microbial classification and the philosophies of systematics and biodiversity. Incorporating microbial insights into the philosophy of biology will challenge many of its assumptions, but also give greater scope and depth to its investigations