An unusual presentation of scabies infestation in a patient with Darier's disease. The use of ivermectin as an adjunctive scabicide

Darier's disease is an inherited condition of defective keratinization in which patients are predisposed to the development of severe viral infections and have an increased susceptibility to bacterial and mycotic infections. We describe a patient with Darier's disease who had a severe form of scabies infestation which responded to treatment with permethrin in combination with ivermectin. The tendency of patients with Darier's disease to develop severe forms of cutaneous infections and infestations may reflect a common underlying mechanism, and their management may require more aggressive therapeutic approaches

Papular dermatitis: response to cyclosporin

BACKGROUND/AIM: Papular dermatitis is a persistent pruritic papular dermatitis, often refractory to treatment. The objective was to examine the effectiveness of cyclosporin for the treatment of this condition. METHODS: A retrospective review was conducted of the medical records of a cohort of 16 patients with papular dermatitis who were treated with cyclosporin within the last 2 years. RESULTS: Twelve of the 16 patients improved. Of those who improved, two discontinued treatment because of side effects such as hypertension, infection, and tremors. In those that responded favorably, the cyclosporin was tapered slowly. Some patients, however, required continuous therapy due to relapse upon discontinuation of the cyclosporin. CONCLUSION: Cyclosporin is an effective treatment for papular dermatitis. (J Dermatol Treat (2000) 11: 253-257