A New Test for the Absorption Mechanism of GPS Radio Sources Using Polarization Properties

We consider the use of polarization properties as a means to discriminate between Synchrotron Self-Absorption (SSA) and Free--Free Absorption (FFA) in GHz-Peaked Spectrum (GPS) sources. The polarization position angle (PA) of synchrotron radiation at high frequencies for the optically thin regime is perpendicular to the magnetic field, whereas it is parallel to the magnetic field at low frequencies for the optically thick regime. Therefore, SSA produces a change in PA of $90^{\circ}$ across the spectral peak, while FFA does not result in such a change. We analyzed polarization data from VLA observations for six GPS sources to see if such a change in PA was present. Our results indicate that there is no significant evidence for $90^{\circ}$ change in PA across the spectral peak, suggesting that FFA is more likely than SSA for low-frequency cutoffs in these sources

Effects of Traffic Control Devices and Road Scenes on a Driver\u27s Judgment of Curve Sharpness

The effects of traffic control devices and road scene on a driver\u27s judgment of curve sharpness were investigated by field experiments on a 12-km section of rural highway running through a hilly area in Hokkaido. The configurations of traffic control devices at 36 curves were obtained from the road maintenance database. The favorability of the road scene was determined subjectively. Each of the 6 subjects drove a vehicle installed with instruments. The subject estimated the sharpness of the target curve before that curve and assessed the accuracy of that judgment subjectively after the target curve. Cluster analysis detected groupings of the 36 curves in terms of driver assessment of sharpness. The traffic control devices were verified as important cues in driver assessment of curve sharpness. In addition, the road scene had a positive effect in daytime on judgment of the target curve. However, there were some dangerous curves where the subjects underestimated the sharpness before entering the curve. Traffic control devices to provide accurate information on curve depth should be developed

Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats

Poststroke depression is one of the major symptoms observed in the chronic stage of brain stroke such as cerebral ischemia. Its pathophysiological mechanisms, however, are not well understood. Using the transient right middle cerebral artery occlusion- (MCAO-, 90 min) operated rats as an ischemia model in this study, we first observed that aggravation of anhedonia spontaneously occurred especially after 20 weeks of MCAO, and it was prevented by chronic antidepressants treatment (imipramine or fluvoxamine). The anhedonia specifically associated with loss of the granular neurons in the ipsilateral side of hippocampal dentate gyrus and was also prevented by an antidepressant imipramine. Immunohistochemical analysis showed increased apoptosis inside the granular cell layer prior to and associated with the neuronal loss, and imipramine seemed to recover the survival signal rather than suppressing the death signal to prevent neurons from apoptosis. Proliferation and development of the neural stem cells were increased transiently in the subgranular zone of both ipsi- and contralateral hippocampus within one week after MCAO and then decreased and almost ceased after 6 weeks of MCAO, while chronic imipramine treatment prevented them partially. Overall, our study suggests new insights for the mechanistic correlation between poststroke depression and the delayed neurodegenerative changes in the hippocampal dentate gyrus with effective use of antidepressants on them

Postischemic Anhedonia Associated with Neurodegenerative Changes in the Hippocampal Dentate Gyrus of Rats

Poststroke depression is one of the major symptoms observed in the chronic stage of brain stroke such as cerebral ischemia. Its pathophysiological mechanisms, however, are not well understood. Using the transient right middle cerebral artery occlusion- (MCAO-, 90 min) operated rats as an ischemia model in this study, we first observed that aggravation of anhedonia spontaneously occurred especially after 20 weeks of MCAO, and it was prevented by chronic antidepressants treatment (imipramine or fluvoxamine). The anhedonia specifically associated with loss of the granular neurons in the ipsilateral side of hippocampal dentate gyrus and was also prevented by an antidepressant imipramine. Immunohistochemical analysis showed increased apoptosis inside the granular cell layer prior to and associated with the neuronal loss, and imipramine seemed to recover the survival signal rather than suppressing the death signal to prevent neurons from apoptosis. Proliferation and development of the neural stem cells were increased transiently in the subgranular zone of both ipsi- and contralateral hippocampus within one week after MCAO and then decreased and almost ceased after 6 weeks of MCAO, while chronic imipramine treatment prevented them partially. Overall, our study suggests new insights for the mechanistic correlation between poststroke depression and the delayed neurodegenerative changes in the hippocampal dentate gyrus with effective use of antidepressants on them

Local sympathetic neurons promote neutrophil egress from the bone marrow at the onset of acute inflammation

This is a pre-copyedited, author-produced version of an article accepted for publication in International Immunology following peer review. The version of record Tomoka Ao, Junichi Kikuta, Takao Sudo, Yutaka Uchida, Kenta Kobayashi, Masaru Ishii, Local sympathetic neurons promote neutrophil egress from the bone marrow at the onset of acute inflammation, International Immunology, Volume 32, Issue 11, November 2020, Pages 727–736. is available online at: https://doi.org/10.1093/intimm/dxaa025

Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains

Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse brains. Pin1 binds to phosphorylated CaMKII and weakens its activity. For this reason, the phosphorylation level of tau in the presence of Pin1 is lower than that in the absence of Pin1, and microtubule polymerization is not downregulated by CaMKII when Pin1 is present. These results suggest a novel mechanism of action of Pin1 to prevent neurodegeneration

A Helical Magnetic Field in the Jet of 3C 273

Both in the Faraday Rotation Measure and the intrinsic polarization angle, new features are revealed to indicate a helical magnetic field operating along the jet of the bright active galactic nuclei 3C 273. The helical field has been suggested to be related to the formation and collimation of jets by magnetohydrodynamic models. The distribution of the RM shows a systematic gradient with respect to the jet axis, which is expected by a helical magnetic field. In addition, the helical field can consistently explain two types in the direction of the projected magnetic field: parallel and perpendicular to the jet axis. Further, if the helical magnetic field is generated by winding up of an initial field by rotation of the accretion disk, we can uniquely determine the direction of the disk rotation, since the jet is approaching us.Comment: 7 pages, 5 figures, PASJ Letters in pres