A Rapid Screening Psychometric Test

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66666/2/10.1177_000992286900800506.pd

International perspectives on the future of geography education: an analysis of national curricula and standards

Geography as a school subject is expressed in a wide variety of ways across different national jurisdictions. This article explores some of the issues arising from attempts to represent geography as a subject for study in schools through the organisational structures offered by national standards and/or national curricula. It serves as an introduction to this special issue, which primarily concerns itself with the contemporary analysis of geography education in seven national settings across the globe. We stress the importance of considering political, cultural, social and philosophical traditions when analysing the curriculum choices made for geography education. Although it may be assumed that geography as a disciplinary specialism is concerned with a body of knowledge that is common across the globe, the creative tensions generated between the disciplines, educational trends and matters of social or policy concern play out differently, making comparisons across jurisdictions hazardous. Understanding this, we argue, is of great significance to those who plan and shape the geography curriculum. Despite the difficulties we hope to offer something more useful than a series of descriptions of geography teaching in different national settings. The purpose of this paper is to introduce a set of robust and irresistible arguments for the inclusion of the study of geography in schools. We argue that geographical knowledge is a vital component of the education of young people across the globe, even though it may be expressed in different ways in different national settings

Mouse Chromosome 3

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46995/1/335_2004_Article_BF00648421.pd

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Process and pattern of curriculum innovation

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN013611 / BLDSC - British Library Document Supply CentreGBUnited Kingdo