Italian Center-Right Parties And Immigration: A Political Patronage Approach

Articlehttp://deepblue.lib.umich.edu/bitstream/2027.42/97001/1/UMURJ-Issue07_2010-TPavone.pd

P1‐504: Influence Of Patient Mci On Physician Conception Of Risk And Decision‐Making For Cardiovascular Treatments

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153216/1/alzjjalz2019061109.pd

University of Michigan Undergraduate Research Journal, Issue 7, Winter 2010

Articlehttp://deepblue.lib.umich.edu/bitstream/2027.42/97002/1/UMURJ-Issue07_2010.pd

Activation of the γ-Tubulin Complex by the Mto1/2 Complex

SummaryThe multisubunit γ-tubulin complex (γ-TuC) is critical for microtubule nucleation in eukaryotic cells [1, 2], but it remains unclear how the γ-TuC becomes active specifically at microtubule-organizing centers (MTOCs) and not more broadly throughout the cytoplasm [3, 4]. In the fission yeast Schizosaccharomyces pombe, the proteins Mto1 and Mto2 form the Mto1/2 complex, which interacts with the γ-TuC and recruits it to several different types of cytoplasmic MTOC sites [5–10]. Here, we show that the Mto1/2 complex activates γ-TuC-dependent microtubule nucleation independently of localizing the γ-TuC. This was achieved through the construction of a “minimal” version of Mto1/2, Mto1/2[bonsai], that does not localize to any MTOC sites. By direct imaging of individual Mto1/2[bonsai] complexes nucleating single microtubules in vivo, we further determine the number and stoichiometry of Mto1, Mto2, and γ-TuC subunits Alp4 (GCP2) and Alp6 (GCP3) within active nucleation complexes. These results are consistent with active nucleation complexes containing ∼13 copies each of Mto1 and Mto2 per active complex and likely equimolar amounts of γ-tubulin. Additional experiments suggest that Mto1/2 multimers act to multimerize the fission yeast γ-tubulin small complex and that multimerization of Mto2 in particular may underlie assembly of active microtubule nucleation complexes

Handbook of Computational Economics

In this chapter, we assess recent contributions of computational models to the study of politics. We focus primarily on agent-based models developed by economists and political scientists. These models address collective action problems, questions related to institutional design and performance, issues in international relations, and electoral competition. In our view, complex systems and computational techniques will have a large and growing impact on research on politics in the near future. This optimism follows from the observation that the concepts used in computational methodology in general and agent-based models in particular resonate deeply within political science because of the domains of study in the discipline and because early findings from agent-based models align with widely known empirical regularities in the political world. In the process of making our arguments, we survey a portion of the growing literature within political science.

P1‐555: Impact Of Patient Mild Cognitive Impairment On Physician Decision‐Making For Treatment

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/152690/1/alzjjalz201806567.pd

Impact of Patient Mild Cognitive Impairment on Physician Decision-Making for Treatment

Background: Older patients with mild cognitive impairment (MCI) should receive evidence-based treatments when clinically indicated. However, patients with MCI appear less likely than cognitively normal patients to receive evidence-based treatments. Objective: To explore the influence of a patient's MCI diagnosis on physician decision-making. Methods: Qualitative study of 18 physicians from cardiology, neurology, and internal medicine using semi-structured interviews. We sought to understand whether and how a patient's having MCI has influenced physicians' decisions about five categories of treatments or tests (surgery, invasive tests, non-invasive tests, rehabilitation, and preventive medication). We used qualitative content analysis to identify the unifying and recurrent themes. Results: Most physician participants described MCI as influencing their recommendations for at least one treatment or test. We identified two major themes as factors that influenced physician recommendations in patients with MCI: Physicians assume that MCI patients' decreased cognitive ability will impact treatment; and physicians assume that MCI patients have poor health status and physical functioning that will impact treatment. These two themes were representative of physician beliefs that MCI patients have impaired independent decision-making, inability to adhere to treatment, inability to communicate treatment preferences, and increased risk and burden from treatment. Conclusion: A patient's MCI diagnosis influences physician decision-making for treatment. Some physician assumptions about patients with MCI were not evidence-based. This phenomenon potentially explains why many patients with MCI get fewer effective treatments or tests than cognitively normal patients. Interventions that improve how physicians understand MCI and make decisions for treatments in patients with MCI are needed

P2‐533: Impact Of Mild Cognitive Impairment On Patient And Care Partner Preferences For Cardiovascular Treatment

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153104/1/alzjjalz2018061227.pd