Histochemical and Morphological Characteristics in Cultures of Normal Human Adrenal Cortex and Adrenocortical Tumors

Histochemical and morphological studies in culture were carried out on 4 cases from the normal human adrenal cortex (NHA), 1 case from CUSHING\u27S adenoma (CS), 4 cases from CONN\u27S adenoma (primary aldosteronism, PA) and 1 case from adrenocortical carcinoma (ACC). Cultured cells from CS and ACC transformed rapidly into fibroblast-like cells, while those from NHA and PA remained on the substratum as epithelial-like cells in the beginning but gradually changed into fibroblast-like cells. Cultured cells from CS and ACC were negative for oil red 0 staining, while lipid droplets in the cytoplasm were prominent in the PA-and NHA-cultured cells. Cells active for 3β-hydroxysteroid dehydrogenase(3β-HSD) were admixed among the ACC-cultured cells and present sporadically in the CS culture. In primary culture of PA and NHA, cells in early passage revealed activity for 3β-HSD but fibrobast-like cells hardly revealed activity. In all the cases, ultrastructural features of the cultured cells varied from those of the original cells, but the cultured cells were contacted each other with interdigitation and desmosome-like structures

Development of a Rapid Temperature Scanning System for Pulsed Magnetic Fields and its Applications

AbstractAn apparatus, which scans temperature in sub-seconds for measuring the temperature dependence of the resistivity, is proposed. This apparatus contains a thermal bath and a sample platform on which a thin-film thermometer and a thin-film heater are sputtered. By thermally isolating the sample platform from surrounding parts, the sample temperature can be scanned at a high sweep rate of 200-300K/s. As a demonstration of the apparatus, the resistivity of a niobium-titanium alloy is measured in a pulsed magnetic field. In addition, as another application of the apparatus, the dielectric polarization measurement of the quantum-paraelectric material SrTiO3 is described

Diffuse Large B-Cell Lymphoma 18 Years After Bilateral Lacrimal Gland IgG4-Related Disease: Case Report and Literature Review

IgG4-related disease is a recently established clinical entity. The disease might serve as the background for later development of systemic lymphoma. This study aims to confirm the diagnosis of IgG4-related disease by re-staining lacrimal gland lesions diagnosed previously with low-grade lymphoma in a patient who developed systemic diffuse large B-cell lymphoma (DLBCL) 18 years later. A 53-year-old man developed bilateral lacrimal gland swelling and right submandibular gland swelling and was diagnosed by excision as low-grade lymphoma. In follow-up, positron emission tomography showed high uptake in the median hyoid 11 years later but no malignancy was detected by laryngeal submucosal biopsy. He was well with no treatment until 18 years later when he had palatal swelling and was diagnosed with DLBCL by oral floor biopsy. He had systemic lymphadenopathy, infiltration in paranasal sinuses, hypopharynx, small intestine, kidney, and prostate. He underwent 8 courses of R-CHOP and 3 courses of high-dose methotrexate and achieved complete remission with no relapse for 1 year thereafter. Re-immunostaining of paraffin blocks of bilateral lacrimal gland lesions showed IgG and IgG4-positive lymphocytes and plasma cells among lymphoid follicles separated by fibrous bundles, with 10 or more IgG4-positive cells in high-power field. The IgG4/IgG-positive cell ratio was 100% and the number of κ chain-positive cells and λ chain-positive cells was the same. The bilateral lacrimal lesions were thus re-diagnosed as IgG4-related disease. In conclusion, systemic DLBCL occurred approximately 20 years after lacrimal gland IgG4-related disease. Literature review revealed 12 patients with IgG4-related disease, including the present patient, who later developed lymphoma in the other organs

Thermal phase transitions to valence-bond-solid phase in the two-dimensional generalized SU(N) Heisenberg models

International Conference on Strongly Correlated Electron Systems 2014 (SCES2014) 7–14 July 2014, Grenoble, France.We study thermal transitions of the generalized SU(N) Heisenberg models with four-body interactions on a square lattice and with six-body interactions on a honeycomb lattice. In both models for the N=3 and 4 cases, a singlet-dimer state is stabilized at a very low temperature, where a rotational symmetry of lattice is broken spontaneously. We discuss the universality class of thermal transition to the singlet dimer phases, performing quantum Monte Carlo calculations. From the finite-size scaling analysis, we find that the criticality for the square lattice case is well explained by the 2D weak Ising universality, while the 2D three-state Potts universality is observed in the honeycomb lattice case