Identifying the Public’s Psychological Concerns in Response to COVID-19 Risk Messages in Singapore

Understanding the social-psychological processes that characterize communities’ reactions to a pandemic is the first step toward formulating risk communications that can lead to better health outcomes. This study examines comments on Facebook pages of five Singapore media outlets to understand what topics are being discussed by the public in reaction to the implemented precautionary measures in Singapore so as to infer their psychological concerns. Using Anchored Correlation Explanation as a topic modelling technique, this study examines around 10,000 comments and identifies 21 topics that are discussed. The 21 topics were categorized and organized into seven broad themes of psychological concerns. Implications for theory and practice are then discussed

A rigorous real time Feynman Path Integral and Propagator

We will derive a rigorous real time propagator for the Non-relativistic Quantum Mechanic $L^2$ transition probability amplitude and for the Non-relativistic wave function. The propagator will be explicitly given in terms of the time evolution operator. The derivation will be for all self-adjoint nonvector potential Hamiltonians. For systems with potential that carries at most a finite number of singularity and discontinuities, we will show that our propagator can be written in the form of a rigorous real time, time sliced Feynman path integral via improper Riemann integrals. We will also derive the Feynman path integral in Nonstandard Analysis Formulation. Finally, we will compute the propagator for the harmonic oscillator using the Nonstandard Analysis Feynman path integral formuluation; we will compute the propagator without using any knowledge of classical properties of the harmonic oscillator

Rigorous Real-Time Feynman Path Integral for Vector Potentials

we will show the existence and uniqueness of a real-time, time-sliced Feynman path integral for quantum systems with vector potential. Our formulation of the path integral will be derived on the $L^2$ transition probability amplitude via improper Riemann integrals. Our formulation will hold for vector potential Hamiltonian for which its potential and vector potential each carries at most a finite number of singularities and discontinuities

Excretion of Host DNA in Feces Is Associated with Risk of Clostridium difficile Infection

Clostridium difficile infection (CDI) is intricately linked to the health of the gastrointestinal tract and its indigenous microbiota. In this study, we assessed whether fecal excretion of host DNA is associated with CDI development. Assuming that shedding of epithelial cell increases in the inflamed intestine, we used human DNA excretion as a marker of intestinal insult. Whole-genome shotgun sequencing was employed to quantify host DNA excretion and evaluate bacterial content in fecal samples collected from patients with incipient CDI, hospitalized controls, and healthy subjects. Human DNA excretion was significantly increased in patients admitted to the hospital for a gastrointestinal ailment, as well as prior to an episode of CDI. In multivariable analyses, human read abundance was independently associated with CDI development. Host DNA proportions were negatively correlated with intestinal microbiota diversity. Enterococcus and Escherichia were enriched in patients excreting high quantities of human DNA, while Ruminococcus and Odoribacter were depleted. These findings suggest that intestinal inflammation can occur prior to CDI development and may influence patient susceptibility to CDI. The quantification of human DNA in feces could serve as a simple and noninvasive approach to assess bowel inflammation and identify patients at risk of CDI

Ultra-fast Au(III)-mediated Arylation of Cysteine

Through mechanistic work and rational design, we have developed the fastest organometallic abiotic Cys bioconjugation. As a result, the developed organometallic Au(III) bioconjugation reagents enable selective labeling of Cys moieties down to pM concentrations and allow for the rapid construction of complex heterostructures from peptides, proteins, and oligonucleo-tides. This work showcases how organometallic chemistry can be interfaced with biomolecules and lead to the range of reac-tivities that are largely unmatched by classical organic chemistry tools

A Brief Overview of the NEBULA Future Internet Architecture

NEBULA is a proposal for a Future Internet Architecture. It is based on the assumptions that: (1) cloud computing will comprise an increasing fraction of the application workload offered to an Internet, and (2) that access to cloud computing resources will demand new architectural features from a network. Features that we have identified include dependability, security, flexibility and extensibility, the entirety of which constitute resilience.NEBULA provides resilient networking services using ultrareliable routers, an extensible control plane and use of multiple paths upon which arbitrary policies may be enforced. We report on a prototype system, Zodiac, that incorporates these latter two features