9 research outputs found
Structure-based development of specific inhibitors for individual cathepsins and their medical applications
Specific inhibitors for individual cathepsins have been developed based on their tertiary structures of X-ray crystallography. Cathepsin B-specific inhibitors, CA-074 and CA-030, and cathepsin L specific inhibitors, CLIK-148 and CLIK-195, were designed as the epoxysuccinate derivatives. Cathepsin S inhibitor, CLIK-060, and cathepsin K inhibitor, CLIK-166, were synthesized. These inhibitors can use in vitro and also in vivo, and show no toxicity for experimental animals by the amounts used as the cathepsin inhibitor
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Deep co-added sky from Catalina Sky Survey images
A number of synoptic sky surveys are underway or being planned. Typically, they are done with small telescopes and relatively short exposure times. A search for transient or variable sources involves comparison with deeper baseline images, ideally obtained through the same telescope and camera. With that in mind, we have stacked images from the 0.68 m Schmidt telescope on Mt. Bigelow taken over 10 yr as part of the Catalina Sky Survey. In order to generate deep reference images for the Catalina Real-time Transient Survey (CRTS), close to 0.8 million images over 8000 fields and covering over 27 000 sq. deg have gone into the deep stack that goes up to 3 mag deeper than individual images. CRTS system does not use a filter in imaging; hence, there is no standard passband in which the optical magnitude is measured. We estimate depth by comparing these wide-band unfiltered co-added images with images in the g band and find that the image depth ranges from 22.0 to 24.2 across the sky, with a 200-image stack attaining an equivalent AB magnitude sensitivity of 22.8. We compared various state-of-the-art software packages for co-adding astronomical images and have used swarp for the stacking. We describe here the details of the process adopted. This methodology may be useful in other panoramic imaging applications, and to other surveys as well. The stacked images are available through a server at Inter-University Centre for Astronomy and Astrophysics. © 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]