Circulating gastrin is increased in hemochromatosis

AbstractGastric acid production is important in intestinal iron absorption. The peptide hormone gastrin exists in both amidated and non-amidated forms, which stimulate and potentiate gastric acid secretion, respectively. Since non-amidated gastrins require ferric ions for biological activity in vitro, this study investigated the connection between iron status and gastrin by measurement of circulating gastrin concentrations in mice and humans with hemochromatosis. Gastrin concentrations are increased in the plasma and gastric mucosa of Hfe−/− mice, and in the sera of humans with HFE-related hemochromatosis. The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis

Opening the Rome-Southampton window for operator mixing matrices

We show that the running of operators which mix under renormalization can be computed fully non-perturbatively as a product of continuum step scaling matrices. These step scaling matrices are obtained by taking the "ratio" of Z matrices computed at different energies in an RI-MOM type scheme for which twisted boundary conditions are an essential ingredient. Our method allows us to relax the bounds of the Rome-Southampton window. We also explain why such a method is important in view of the light quark physics program of the RBC-UKQCD collaborations. To illustrate our method, using n_f=2+1 domain-wall fermions, we compute the non-perturbative running matrix of four-quark operators needed in K->pipi decay and neutral kaon mixing. Our results are then compared to perturbation theory.Comment: 8 pages, 7 figures. v2: PRD version, minor changes and few references adde

Riparian Zone Nitrogen Management through the Development of the Riparian Ecosystem Management Model (REMM) in a Formerly Glaciated Watershed of the US Northeast

The Riparian Ecosystem Management Model (REMM) was developed, calibrated and validated for both hydrologic and water quality data for eight riparian buffers located in a formerly glaciated watershed (upper Pawcatuck River Watershed, Rhode Island) of the US Northeast. The Annualized AGricultural Non-Point Source model (AnnAGNPS) was used to predict the runoff and sediment loading to the riparian buffer. Overall, results showed REMM simulated water table depths (WTDs) and groundwater NO3-N concentrations at the stream edge (Zone 1) in good agreement with measured values. The model evaluation statistics showed that, hydrologically REMM performed better for site 1, site 4, and site 8 among the eight buffers, whereas REMM simulated better groundwater NO3-N concentrations in the case of site 1, site 5, and site 7 when compared to the other five sites. The interquartile range of mean absolute error for WTDs was 3.5 cm for both the calibration and validation periods. In the case of NO3-N concentrations prediction, the interquartile range of the root mean square error was 0.25 mg/L and 0.69 mg/L for the calibration and validation periods, respectively, whereas the interquartile range of d for NO3-N concentrations was 0.20 and 0.48 for the calibration and validation period, respectively. Moreover, REMM estimation of % N-removal from Zone 3 to Zone 1 was 19.7%, and 19.8% of N against actual measured 19.1%, and 26.6% of N at site 7 and site 8, respectively. The sensitivity analyses showed that changes in the volumetric water content between field capacity and saturation (soil porosity) were driving water table and denitrification

Entrepreneurially Minded Learning in the Unit Operations Laboratory through Community Engagement in a Blended Teaching Environment

Online and blended learning opportunities in Chemical Engineering curriculum emerged due to COVID-19. After eight weeks of in-person Unit Operations Laboratory sessions, a remote-learning open-ended final project was assigned to student teams. The assignment involved aspects related to entrepreneurial-minded learning (EML) and community-based learning (CBL). Results show correlations between self-directed learning and the EML framework. Continuous support and involvement of a community partner correlate to students\u27

Beaver Ponds: Resurgent Nitrogen Sinks for Rural Watersheds in the Northeastern United States

Beaver-created ponds and dams, on the rise in the northeastern United States, reshape headwater stream networks from extensive, free-flowing reaches to complexes of ponds, wetlands, and connecting streams. We examined seasonal and annual rates of nitrate transformations in three beaver ponds in Rhode Island under enriched nitrate-nitrogen (N) conditions through the use of 15N mass balance techniques on soil core mesocosm incubations. We recovered approximately 93% of the nitrate N from our mesocosm incubations. Of the added nitrate N, 22 to 39% was transformed during the course of the incubation. Denitrification had the highest rates of transformation (97–236 mg N m−2 d−1), followed by assimilation into the organic soil N pool (41–93 mg N m−2 d−1) and ammonium generation (11–14 mg N m−2 d−1). Our denitrification rates exceeded those in several studies of freshwater ponds and wetlands; however, rates in those ecosystems may have been limited by low concentrations of nitrate. Assuming a density of 0.7 beaver ponds km−2 of catchment area, we estimated that in nitrate-enriched watersheds, beaver pond denitrification can remove approximately 50 to 450 kg nitrate N km−2 catchment area. In rural watersheds of southern New England with high N loading (i.e., 1000 kg km−2), denitrification from beaver ponds may remove 5 to 45% of watershed nitrate N loading. Beaver ponds represent a relatively new and substantial sink for watershed N if current beaver populations persist