1,826 research outputs found
Stepwise fabrication and optimization of coplanar waveguide resonator hybrid devices
From the background of microwave-optomechanical experiments involving carbon
nanotubes, the optimization of superconducting coplanar waveguide resonator
devices is discussed. Two devices, one with unmodified geometry compared to
previous work and one integrating several improvements, are lithographically
built up step by step. After each step, the low temperature GHz transmission
properties are retested. This allows to identify the impact of the fabrication
and the geometry modification on the device properties. In addition, simplified
circuit geometries are modeled numerically, confirming the experimental results
and providing further insights for optimization.Comment: 4 figure, 5 page
Media events, spectacles and risky globalization: a critical review and possible avenues for future research
We review the research conducted to date on media events and media spectacles. We posit that the main phenomena challenging the current conceptualizations of media event and media spectacle are (1) the understanding of risk, (2) the context of disasters and (3) globalization and the mediation of news in the context of transnational and transitional societies. We suggest that more research on disruptive events is needed. In the context of the new media landscape in particular, the ritual researcher may need to take into account the concepts of temporality and unpredictability as inherent features of media events and rituals – the traumatic events researcher may benefit from the concept of global risk society. Finally, we argue that more research needs to be carried out on transitional societies, as we need to learn more about the role of mediation, events and spectacles in democratization processes and in contemporary revolutions. Overall, our findings indicate that in the context of global risk society, constant disruptions and unplanned events, together with the changes in news transmission, need to be taken as a starting point also in the research frames used to understand the mediation of events in contemporary society
The SPF27 Homologue Num1 Connects Splicing and Kinesin 1-Dependent Cytoplasmic Trafficking in Ustilago maydis
The conserved NineTeen protein complex (NTC) is an integral subunit of the spliceosome and required for intron removal during pre-mRNA splicing. The complex associates with the spliceosome and participates in the regulation of conformational changes of core spliceosomal components, stabilizing RNA-RNA- as well as RNA-protein interactions. In addition, the NTC is involved in cell cycle checkpoint control, response to DNA damage, as well as formation and export of mRNP-particles. We have identified the Num1 protein as the homologue of SPF27, one of NTC core components, in the basidiomycetous fungus Ustilago maydis. Num1 is required for polarized growth of the fungal hyphae, and, in line with the described NTC functions, the num1 mutation affects the cell cycle and cell division. The num1 deletion influences splicing in U. maydis on a global scale, as RNA-Seq analysis revealed increased intron retention rates. Surprisingly, we identified in a screen for Num1 interacting proteins not only NTC core components as Prp19 and Cef1, but several proteins with putative functions during vesicle-mediated transport processes. Among others, Num1 interacts with the motor protein Kin1 in the cytoplasm. Similar phenotypes with respect to filamentous and polar growth, vacuolar morphology, as well as the motility of early endosomes corroborate the genetic interaction between Num1 and Kin1. Our data implicate a previously unidentified connection between a component of the splicing machinery and cytoplasmic transport processes. As the num1 deletion also affects cytoplasmic mRNA transport, the protein may constitute a novel functional interconnection between the two disparate processes of splicing and trafficking
Descrição da série caudal de um titanosaurídeo do Grupo Bauru, Cretáceo Superior do Brasil
A new titanosaurid, Baurutitan britoi n. gen., n. sp., is described and compared with other taxa of that sauropod clade. The specimen (MCT 1490-R) consists of the last sacral followed by a sequence of 18 caudal vertebrae that were found in the continental deposits of the Late Cretaceous Bauru Group that outcrop at the Peirópolis region, near the town of Uberaba, State of Minas Gerais, Brazil. This new taxon is distinguished from other titanosaurians by several features, including subrectangular to square outline of the anterior articulation surface of the anterior and middle caudals, strongly pointed laterally directed process intercepting the spinoprezygapophyseal lamina in caudal 1; dorsal prezygapophyseal tuberosity on the lateral margin of the prezygapophyses of caudals 2-4, that smoothens out in midcaudals. This material demonstrates that the horizontal ridge present in middle and posterior caudals of some titanosaurs, inBaurutitan britoi is homologous with a dorsal tuberosity and not with the transverse process.Um novo titanossaurídeo, Baurutitan britoi n. gen., n. sp., é descrito e comparado com outros membros desse clado de saurópodes. O espécime é composto por uma última vértebra sacral seguida de uma seqüência de 18 vértebras caudais (MCT 1490-R) proveniente das cercanias do povoado de Peirópolis, no Município de Uberaba (Estado de Minas Gerais, Brasil), tendo sido encontrado nos depósitos continentais do Grupo Bauru (Cretáceo Superior). Entre as características que distinguem esse novo táxon dos demais Titanosauria estão a face subretangular ou quadrada da articulação anterior das caudais, processo lateral bem desenvolvido interceptando a lamina espinopré-zigapofisiária da caudal 1, tubérculo dorsal na margem lateral das pré-zigapófises das caudais 2-4, que se torna em uma rugosidade que tende a se tornar menos pronunciada nas caudais médias. Este material também demonstra que em Baurutitan britoi n. gen., n. sp. a crista lateral nos centros das caudais medianas é o resultado de uma diminuição de um processo dorsal e não é homólogo do processo transverso
An attempt to optimize the outcome of penetrating keratoplasty in congenital aniridia-associated keratopathy (AAK)
Purpose
To propose an optimized microsurgical and medical approach to reduce the risk of complications after penetrating keratoplasty (PKP) in patients with aniridia-associated keratopathy (AAK).
Methods
Retrospective observational case series of 25 PKP performed in 16 patients with AAK. Preoperative indications were endothelial decompensation and vascularized scars (68%) or graft failure (32%) due to limbal stem cell deficiency. The optimized approach included a combination of a small corneal graft size (around 7.0 mm), interrupted 10–0nylon sutures, simultaneous AMT as a patch, large bandage contact lens, temporary lateral tarsorrhaphy, postoperative autologous serum eye drops, and systemic immunosuppression. Main outcome measures included: visual acuity, transplant survival, and complications encountered during follow-up of 107 weeks on average.
Results
A complete modified keratoplasty scheme was used in 10 of 25 PKP (group 1), while at least one of the modifications was missing in the other 15 PKP (group 2). After 8 weeks of follow-up, the epithelium was closed in 23 eyes. Visual acuity improved in 19 eyes at 6 months of follow-up, and remained stable in six eyes. None of the eyes showed a decrease in visual acuity. At the last post-operative follow-up, this visual improvement persisted in 14 eyes and graft survival rate after 156 weeks (3 years) was 69% in group 1 versus 44% in group 2 (p = 0.39, log-rank test). Secondary corneal neovascularization (8%), scarring (4%), ulcer (4%), or graft rejection (8%) happened mostly in the second group which was missing at least one of the suggested modifications.
Conclusions
PKP in congenital aniridia must be considered as a high-risk keratoplasty. An optimized therapeutic approach seems to be promising in order to reduce the postoperative complication rate in these most difficult eyes
Collaborating for Success: A Case Study on Mentoring, Partnering, and Teaching
Master of Library and Information Science (MLIS) graduates seeking employment in academic libraries are often expected to possess user instruction and public service skills. However, it is difficult for students to achieve this experience through coursework alone. To address this disconnect, librarians at the University of Maryland (UMD) College Park Libraries created a Research and Teaching Fellowship to allow MLIS students at UMD to gain practical instruction experience. The authors present the experience of one MLIS student in collaboration with a subject librarian and a faculty member to plan, implement, and assess an information literacy instruction session for an undergraduate course in public health. The article discusses the benefits of mentoring for the MLIS student and subject liaison librarian, and the impact on the undergraduate student learning. This article addresses a gap in the literature on opportunities for MLIS students to gain instruction, collaboration, and assessment experience by presenting a successful model in place at UMD
Public crises, public futures
This article begins to map out a novel approach to analyzing contemporary contexts of public crisis, relationships between them and possibilities that these scenes hold out for politics. The article illustrates and analyses a small selection of examples of these kinds of contemporary scenes and calls for greater attention to be given to the conditions and consequences of different forms and practices of public and political mediation. In offering a three-fold typology to delineate differences between ‘abject’, ‘audience’ and ‘agentic’ publics the article begins to draw out how political and public futures may be seen as being bound up with how the potentialities, capacities and qualities that publics are imagined to have and resourced to perform. Public action and future publics are therefore analysed here in relation to different versions of contemporary crisis and the political concerns and publics these crises work to articulate, foreground and imaginatively and practically support
Potential Distribution of Six North American Higher-Attine Fungus-Farming Ant (Hymenoptera: Formicidae) Species
Ants are among the most successful insects in Earth’s evolutionary history. However, there is a lack of knowledge regarding range-limiting factors that may influence their distribution. The goal of this study was to describe the environmental factors (climate and soil types) that likely impact the ranges of five out of the eight most abundant Trachymyrmex species and the most abundant Mycetomoellerius species in the United States. Important environmental factors may allow us to better understand each species’ evolutionary history. We generated habitat suitability maps using MaxEnt for each species and identified associated most important environmental variables. We quantified niche overlap between species and evaluated possible congruence in species distribution. In all but one model, climate variables were more important than soil variables. The distribution of M. turrifex (Wheeler, W.M., 1903) was predicted by temperature, specifically annual mean temperature (BIO1), T. arizonensis (Wheeler, W.M., 1907), T. carinatus, and T. smithi Buren, 1944 were predicted by precipitation seasonality (BIO15), T. septentrionalis (McCook, 1881) were predicted by precipitation of coldest quarter (BIO19), and T. desertorum (Wheeler, W.M., 1911) was predicted by annual flood frequency. Out of 15 possible pair-wise comparisons between each species’ distributions, only one was statistically indistinguishable (T. desertorum vs T. septentrionalis). All other species distribution comparisons show significant differences between species. These models support the hypothesis that climate is a limiting factor in each species distribution and that these species have adapted to temperatures and water availability differently
Influence of Medium Chain Fatty Acids on Some Botrytised Wine-Related Yeast Species and on Spontaneous Refermentation of Tokaj Essence
Medium chain fatty acids are candidates of partial sulphur dioxide replacement in wine, as a solution to the growing consumer concerns about chemical additives. In botrytised sweet wine specialties, large amount of sulphur dioxide addition is one of the effective practices to stop alcoholic fermentation. Increasing medium chain fatty acid levels up to 80 mg l–1 was tested as a sole inhibitor on solid agar surface. S. bacillaris seemed to be the most sensitive, S. cerevsisiae and S. bayanus were more tolerant, while Z. bailii showed the highest tolerance. Then, increasing medium chain fatty acid levels up to 40 mg l–1 combined with 100 mg l–1 sulphur dioxide was introduced into a Tokaj Essence under refermentation. After 56 days, the highest dosage had pronounced effect on the yeast population, but the refermentation was not inhibited completely. Medium chain fatty acids have varying inhibitory effect on botrytised wine-related yeasts, moreover, it could be used effectively in media with high ethanol content, unlike Tokaj Essence
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