Polynuclear formation in aqueous solutions containing iron (III) and selected carboxylic acids

Thesis (M.A.)--Boston UniversityOver the past several years various workers have accumulated evidence for the existence of polynuclear complexes of a number of metal ions. In this connection it has been established that iron(III) forms polynuclear species with a variety of common complexing agents. In the present work an investigation was carried out on systems containing iron(III) and selected carboxylic acids. An attempt was made to classify the systems according to whether or not they formed polynuclear species. For some systems it was established under what conditions polynuclear species are present and under what conditions they are not present. [TRUNCATED

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field