nQuire for the OpenScience Lab: supporting communities of inquiry learning

We have developed a platform to support Citizen Inquiry activities, based on the nQuire Toolkit software which was originally de- signed to support inquiry-based learning activities for schools. Citizen Inquiry is an innovative way for learners to engage in practical scientific activities, in which they take the role of self-regulated scientists in informal learning contexts. The platform will be integrated with the OpenScience Laboratory and will allow individuals or groups to create inquiries that rely on virtual scientific instruments for collecting scientifically reliable data. A demonstration inquiry has been created using the Open University Virtual Microscope that enables learners to conduct investigations of lunar geology by studying rare and authentic samples of Moon rock collected during the Apollo programme. Inquiries created using such instruments are intended to arouse a sense of wonder in members of the public, attract learners to science, and build communities of users around non-professional yet authentic scientific activities. This demonstration will show the nQuire authoring tools and the prototype inquiry, focusing on the integration of the scientific tool and features that facilitate collaboration in citizen inquiries

Estimation of Groundwater Recharge in Texas Related to Aquifer Vulnerability to Contamination

This study aimed to estimate groundwater recharge rates for major porous media aquifers in Texas, essential for assessing aquifer vulnerability to contamination. Recharge rates were estimated through one-dimensional unsaturated flow modeling and limited field studies in the Southern High Plains and Seymour aquifers. Field studies involved measuring soil physics and environmental tracers in soil samples from boreholes in various land use settings. Numerical modeling of unsaturated flow utilized long-term climatic data, soils data, and vegetation data. Simulated recharge rates varied from 54 mm/yr in west Texas to 720 mm/yr in east Texas, positively correlated with precipitation. High recharge rates in east Texas suggest climate is not the limiting factor, with soil texture and vegetation playing crucial roles in reducing recharge. Layered soil profiles led to locally variable recharge estimates, but areally weighted averages were less variable and positively correlated with precipitation. Vegetation significantly reduced recharge rates in all cases, with simulations including vegetation and layered soil profiles resulting in recharge rates ranging from 0.2 to 114 mm/yr. The 30-year average recharge rates across simulated stations in the state were positively correlated with precipitation, suggesting long-term precipitation as a predictor of recharge. This comprehensive approach provides valuable insights into groundwater recharge dynamics, crucial for assessing aquifer vulnerability to contamination.Bureau of Economic Geolog

Bottle-Feeding Practices During Early Infancy and Eating Behaviors at 6 Years of Age

BACKGROUND: Evidence suggests an association of breastfeeding with a maternal feeding style (MFS) that is less controlling than formula feeding, which, in turn, may improve a child’s self-regulation of eating. This study examines associations of bottle-feeding practices during infancy with MFS and children’s eating behavior (CEB) at 6 years old. METHODS: We linked data from the Infant Feeding Practices Study II to the Year 6 Follow-Up, which include 8 MFS and CEB measures adapted from previous validated instruments. Bottle-feeding practices during the first 6 months estimated by using the Infant Feeding Practices Study II were bottle-feeding intensity (BFI), mother’s encouragement of infant to finish milk in the bottle, and infant finishing all milk in the bottle. Adjusted odds ratios (aORs) for associations of bottle-feeding practices with MFS and CEB at 6 years old were calculated by using multivariable logistic regressions controlling for sociodemographic characteristics and other feeding practices (N = 1117). RESULTS: Frequent bottle emptying encouraged by mothers during infancy increased odds of mothers encouraging their child to eat all the food on their plate (aOR: 2.37; 95% confidence interval [CI]: 1.65–3.41] and making sure their child eats enough (aOR: 1.62; 95% CI: 1.14–2.31) and of children eating all the food on their plate at 6 years old (aOR: 2.01; 95% CI: 1.05–3.83). High BFI during early infancy also increased the odds of mothers being especially careful to ensure their 6-yearold eats enough. CONCLUSIONS: Bottle-feeding practices during infancy may have longterm effects on MFS and CEB. Frequent bottle emptying encouraged by mothers and/or high BFI during early infancy increased the likelihood of mothers pressuring their 6-year-old child to eat and children’s low satiety responsiveness

Ground Water Surface Water Interactions in Texas

Groundwater-surface water interactions need to be evaluated to optimize water management in Texas. This study provides an overview of the impacts of groundwater-surface water (gw-sw) interactions on water quality and water quantity using available data. A literature review was conducted to assess the status of knowledge of gw-sw interactions. A total of 300 references were compiled. References were subdivided into those related to water quantity issues, water quality including point and nonpoint sources of contamination, and methods such as seepage and temperature approaches and modeling analyses. Additional topics covered by the reference list include impacts of climate variability and land use/land cover changes on gw-sw interactions and ecological issues. A compilation of data and information sources for assessing gw-sw interactions in Texas is also provided. This section includes web links to online report catalogs and databases and a listing of offline reports and catalogs provided by state and federal agencies.Bureau of Economic Geolog

Blended and online learning: A comparative study of virtual microscopy in Higher Education

Virtual Learning Environments (VLEs) are becoming commonplace in Higher Education. Amongst the latest VLE developments is the design and use of Virtual Microscopes (VMs) that allow for viewing and manipulation of online images by multiple students. Although students are found to be generally satisfied with the use of VMs, it is yet not known what teaching and learning conditions better support their use and lead to enhanced learning outcomes. The aim of this paper is to compare the usage patterns and perceptions of two different cohorts of undergraduate students that made use of the VM in blended and online only learning conditions respectively, and draw conclusions about the pedagogy that better supports teaching and learning with VMs. Data collected from a survey with 139 students and 11 semistructured interviews revealed that blended learning better caters for students' engagement and satisfaction due to the systematic use of the VM in course design, its complementary use with a physical microscope, and the ongoing provision of tutors' support and guidance. Equally good perceived learning gains were reported by both blended and online only students. Implications for the design of learning environments around virtual microscopy are discussed

More than a century of bathymetric observations and present-day shallow sediment characterization in Belfast Bay, Maine, USA: implications for pockmark field longevity

This paper is not subject to U.S. copyright. The definitive version was published in Geo-Marine Letters 31 (2011): 237-248, doi:10.1007/s00367-011-0228-0.Mechanisms and timescales responsible for pockmark formation and maintenance remain uncertain, especially in areas lacking extensive thermogenic fluid deposits (e.g., previously glaciated estuaries). This study characterizes seafloor activity in the Belfast Bay, Maine nearshore pockmark field using (1) three swath bathymetry datasets collected between 1999 and 2008, complemented by analyses of shallow box-core samples for radionuclide activity and undrained shear strength, and (2) historical bathymetric data (report and smooth sheets from 1872, 1947, 1948). In addition, because repeat swath bathymetry surveys are an emerging data source, we present a selected literature review of recent studies using such datasets for seafloor change analysis. This study is the first to apply the method to a pockmark field, and characterizes macro-scale (>5 m) evolution of tens of square kilometers of highly irregular seafloor. Presence/absence analysis yielded no change in pockmark frequency or distribution over a 9-year period (1999–2008). In that time pockmarks did not detectably enlarge, truncate, elongate, or combine. Historical data indicate that pockmark chains already existed in the 19th century. Despite the lack of macroscopic changes in the field, near-bed undrained shear-strength values of less than 7 kPa and scattered downcore 137Cs signatures indicate a highly disturbed setting. Integrating these findings with independent geophysical and geochemical observations made in the pockmark field, it can be concluded that (1) large-scale sediment resuspension and dispersion related to pockmark formation and failure do not occur frequently within this field, and (2) pockmarks can persevere in a dynamic estuarine setting that exhibits minimal modern fluid venting. Although pockmarks are conventionally thought to be long-lived features maintained by a combination of fluid venting and minimal sediment accumulation, this suggests that other mechanisms may be equally active in maintaining such irregular seafloor morphology. One such mechanism could be upwelling within pockmarks induced by near-bed currents.Graduate support for Brothers came from a Maine Economic Improvement Fund Dissertation Fellowship

Protein expression profiles indicative for drug resistance of non-small cell lung cancer

Data obtained from multiple sources indicate that no single mechanism can explain the resistance to chemotherapy exhibited by non-small cell lung carcinomas. The multi-factorial nature of drug resistance implies that the analysis of comprising expression profiles may predict drug resistance with higher accuracy than single gene or protein expression studies. Forty cellular parameters (drug resistance proteins, proliferative, apoptotic, and angiogenic factors, products of proto-oncogenes, and suppressor genes) were evaluated mainly by immunohistochemistry in specimens of primary non-small cell lung carcinoma of 94 patients and compared with the response of the tumours to doxorubicin in vitro. The protein expression profile of non-small cell lung carcinoma was determined by hierarchical cluster analysis and clustered image mapping. The cluster analysis revealed three different resistance profiles. The frequency of each profile was different (77, 14 and 9%, respectively). In the most frequent drug resistance profile, the resistance proteins P-glycoprotein/MDR1 (MDR1, ABCB1), thymidylate-synthetase, glutathione-S-transferase-π, metallothionein, O6-methylguanine-DNA-methyltransferase and major vault protein/lung resistance-related protein were up-regulated. Microvessel density, the angiogenic factor vascular endothelial growth factor and its receptor FLT1, and ECGF1 as well were down-regulated. In addition, the proliferative factors proliferating cell nuclear antigen and cyclin A were reduced compared to the sensitive non-small cell lung carcinoma. In this resistance profile, FOS was up-regulated and NM23 down-regulated. In the second profile, only three resistance proteins were increased (glutathione-S-transferase-π, O6-methylguanine-DNA-methyltransferase, major vault protein/lung resistance-related protein). The angiogenic factors were reduced. In the third profile, only five of the resistance factors were increased (MDR1, thymidylate-synthetase, glutathione-S-transferase-π, O6-methylguanine-DNA-methyltransferase, major vault protein/lung resistance-related protein)