Influence of container structures and content solutions on dispensing time of ophthalmic solutions

Keiji Yoshikawa1, Hiroshi Yamada21Yoshikawa Eye Clinic, Tokyo, Japan; 2Santen Pharmaceutical Co., Ltd., Osaka, JapanPurpose: To investigate the influence of container structures and content solutions on the time of dispensing from eye dropper bottles.Methods: Eye dropper bottle models, solution models (filtrate water/surfactant solution) and a dispensing time measuring apparatus were prepared to measure the dispensing time.Results: With filtrate water and pressure thrust load of 0.3 MPa, the dispensing time significantly increased from 1.1 ± 0.5 seconds to 4.6 ± 1.1 seconds depending on the decrease of inner aperture diameters from 0.4 mm to 0.2 mm (P < 0.0001). When using the bottle models with inner aperture diameters of 0.4 mm or larger, the dispensing time became constant. The dispensing time using surfactant solution showed the same tendency as above. When pressure thrust load was large (0.07 MPa), the solution flew out continuously with inner aperture diameters of 0.4 mm or larger and the dispensing time could not be measured. The inner aperture diameter most strongly explained the variation of the dispensing time in both the content solutions in the multiple linear regression analysis (filtrate water: 46%, R2 = 0.462, surfactant solution: 56%, R2 = 0.563).Conclusions: Among content solutions and container structures, the dispensing time was mostly influenced by the diameter of the inner aperture of bottles.Keywords: dispensing time, model eye dropper bottle, model ophthalmic solution, nozzle internal space volume, nozzle inner aperture diamete

Ability of Three Temperate Grasses to Compete with \u3cem\u3ePhalaris arundinacea\u3c/em\u3e L.

Weeds with rhizomes have become an ever-increasing problem in the grasslands of Hokkaido in northern Japan. Many meadows in the Tenpoku region, located in the northernmost part of Hokkaido, have been invaded by Phalaris arundinacea L., a grass with aggressive colonising ability known as the primary and most difficult to control weed in the Tenpoku region. However, dairy farmers in the grasslands of the Tenpoku region most commonly cultivate Phleum pratense L., in spite of its low competitive ability. The Tenpoku region frequently experiences years of low rainfall or drought, but P. pratense has low tolerance to drought (Okamoto et al., 2012; Okamoto and Furudate, 2010). Lolium perenne L. and Dactylis glomerata L. are also cultivated in the Tenpoku region, where they are used as rough forages; however, they are much less commonly cultivated than P. pratense. These species are thought to possess not only higher competitive ability than other grasses, but also higher drought tolerance than P. pratense, and thus may be more suitable for cultivation in some parts of the Tenpoku region. Therefore, we suggest that farmers choose a grass species suitable for their land. To further develop this concept, it is necessary to elucidate the differences among the abilities of these species to compete with invading P. arundinacea. Therefore, the objective of this study was to evaluate and compare the competitive ability of these temperate grass species (L. perenne, D. glomerata, and P. pratense) with those of P. arundinacea

Grid-Based Exclusive Region Design for 3D UAV Networks: A Stochastic Geometry Approach

This paper presents a stochastic geometry analysis of radio interference and a grid-based design of a primary exclusive region (PER) for spectrum sharing in the 3D unmanned aerial vehicle (UAV) networks. When a UAV network shares frequency bands with a primary system (e.g., a weather radar system), the UAVs must avoid harmful interference with the primary system. To facilitate the design of a complex-shaped PER according to a primary user's antenna pattern, spatial grid models, namely cylindrical and cubic grid models, are introduced. In the cylindrical grid model, to approximate the distribution of the interference at the radar, the cumulants of the interference are expressed by expressions with simple integrals or even closed-form expressions based on the assumption that the distributions of the UAVs in each grid cell follow an inhomogeneous 3D Poisson point process (PPP). In the cubic grid model, the shape of the grid cell is approximated by the cylindrical grid cell to derive the cumulants of the interference because they cannot be calculated in the same manner as in the cylindrical grid model. Using the derived interference cumulants to determine a PER to satisfy the radar's outage probability target, an optimization problem that minimizes the number of the UAVs forbidden from transmitting signals is formulated. The numerical results confirm that the approximated interference distribution using cumulants is in acceptable agreement with the simulation results and the PER obtained from the proposed optimization problem improves the number of the transmitting UAVs by reducing the volume of grid cells

Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region

In June 2020, the Japanese government approved boron neutron capture therapy for the treatment of head and neck cancer. The treatment is usually performed in a single fraction, with the neutron irradiation time being approximately 30–60 min. As neutrons scatter in air and loses its intensity, it is preferable to bring the patient as close to the beam port as possible to shorten the irradiation time. However, this can be a challenge, especially for patients with head and neck cancer, as the shoulders are an obstacle to a clean positioning. In this study, a novel neutron collimation system for an accelerator based neutron source was designed to allow for a more comfortable treatment, without compromising the irradiation time. Experimental measurements confirmed the simulation results and showed the new collimator can reduce the irradiation time by approximately 60% (under the same condition where the distance between the source and the patient surface was kept the same). The dose delivered to the surrounding healthy tissue was reduced with the new collimator, showing a 25% decrease in the D₅₀ of the mucosal membrane. Overall, the use of the newly designed collimator will allow for a more comfortable treatment of the head and neck region, reduce the treatment time, and reduce the dose delivered to the surrounding healthy tissue

Differences in the Optimal Motion of Android Robots for the Ease of Communications Among Individuals With Autism Spectrum Disorders

Android robots are employed in various fields. Many individuals with autism spectrum disorders (ASD) have the motivation and aptitude for using such robots. Interactions with these robots are structured to resemble social situations in which certain social behaviors can occur and to simulate daily life. Considering that individuals with ASD have strong likes and dislikes, ensuring not only the optimal appearance but also the optimal motion of robots is important to achieve smooth interaction and to draw out the potential of robotic interventions. We investigated whether individuals with ASD found it easier to talk to an android robot with little motion (i.e., only opening and closing its mouth during speech) or an android robot with much motion (i.e., in addition to opening and closing its mouth during speech, moving its eyes from side to side and up and down, blinking, deeply breathing, and turning or moving its head or body at random). This was a crossover study in which a total of 25 participants with ASD experienced mock interviews conducted by an android robot with much spontaneous facial and bodily motion and an android robot with little motion. We compared demographic data between participants who answered that the android robot with much motion was easier to talk to than android robot with little motion and those who answered the opposite. In addition, we investigated how each type of demographic data was related to participants\u27 feeling of comfort in an interview setting with an android robot. Fourteen participants indicated that the android robot with little motion was easier to talk to than the robot with much motion, whereas 11 participants answered the opposite. There were significant differences between these two groups in the sensory sensitivity score, which reflects the tendency to show a low neurological threshold. In addition, we found correlations between the sensation seeking score, which reflects the tendency to show a high neurological threshold, and self-report ratings of comfort in each condition. These results provide preliminary support for the importance of setting the motion of an android robot considering the sensory traits of ASD

Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study

AbstractBackgroundThe radiographic evaluation of the response to preoperative chemotherapy for bone and soft tissue sarcomas is based mostly on the change in primary tumor size before and after chemotherapy, as is done for many solid cancers. Its prognostic correlation, however, has hardly been validated.MethodsWe conducted a retrospective validation study of the Japanese Orthopaedic Association (JOA) radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas as a JOA Committee on Musculoskeletal Tumors cooperative study. A total of 125 consecutive patients with high-grade bone (n = 77) and soft tissue (n = 48) sarcomas treated with neoadjuvant chemotherapy and definitive surgery in 25 tertiary referral hospitals were selected for the study. We investigated the correlation between the tumor size-based radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas provided by the JOA Committee on Musculoskeletal Tumors (hereafter called the JOA criteria) and the patients’ overall survival using the Kaplan-Meier method and the log-rank test.ResultsThe JOA criteria correlated relatively well with survival for malignant bone tumors (mostly comprising osteosarcoma and Ewing’s sarcoma) but not for soft tissue sarcomas, suggesting that the tumor size-based radiographic evaluation criteria for the response to preoperative chemotherapy in patients with soft tissue sarcomas is invalid.ConclusionsThe JOA criteria, based on the change in primary tumor size, is valid for malignant bone tumors but invalid for soft tissue sarcomas. Other new evaluation modalities of the response to preoperative chemotherapy using innovative functional imaging techniques are needed for soft tissue sarcomas

Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN®): review of development and future perspectives

The mechanism of action of protein-bound polysaccharide K (PSK; KRESTIN®) involves the following actions: (1) recovery from immunosuppression induced by humoral factors such as transforming growth factor (TGF)-β or as a result of surgery and chemotherapy; (2) activation of antitumor immune responses including maturation of dendritic cells, correction of Th1/Th2 imbalance, and promotion of interleukin-15 production by monocytes; and (3) enhancement of the antitumor effect of chemotherapy by induction of apoptosis and inhibition of metastasis through direct actions on tumor cells. The clinical effectiveness of PSK has been demonstrated for various cancers. In patients with gastric or colorectal cancer, combined use of PSK with postoperative adjuvant chemotherapy prolongs survival, and this effect has been confirmed in multiple meta-analyses. For small-cell lung carcinoma, PSK in conjunction with chemotherapy prolongs the remission period. In addition, PSK has been shown to be effective against various other cancers, reduce the adverse effects of chemotherapy, and improve quality of life. Future studies should examine the effects of PSK under different host immune conditions and tumor properties, elucidate the mechanism of action exhibited in each situation, and identify biomarkers