All-Digital Computing-in-Memory Macro Supporting FP64-Based Fused Multiply-Add Operation

Recently, frequent data movement between computing units and memory during floating-point arithmetic has become a major problem for scientific computing. Computing-in-memory (CIM) is a novel computing paradigm that merges computing logic into memory, which can address the data movement problem with excellent power efficiency. However, the previous CIM paradigm failed to support double-precision floating-point format (FP64) due to its computing complexity. This paper presents a novel all-digital CIM macro-DCIM-FF to complete FP64 based fused multiply-add (FMA) operation for the first time. With 16 sub-CIM cells integrating digital multipliers to complete mantissa multiplication, DCIM-FF is able to provide correct rounded implementations for normalized/denormalized inputs in round-to-nearest-even mode and round-to-zero mode, respectively. To evaluate our design, we synthesized and tested the DCIM-FF macro in 55-nm CMOS technology. With a minimum power efficiency of 0.12 mW and a maximum computing efficiency of 26.9 TOPS/W, we successfully demonstrated that DCIM-FF can run the FP64-based FMA operation without error. Compared to related works, the proposed DCIM-FF macro shows significant power efficiency improvement and less area overhead based on CIM technology. This work paves a novel pathway for high-performance implementation of an FP64-based matrix-vector multiplication (MVM) operation, which is essential for hyperscale scientific computing

Effects of Craniotomy and Endoscopic Endonasal Transsphenoidal Surgery on Bodyweight in Adult-Onset Craniopharyngioma: A Single-Center Retrospective Study

Craniopharyngioma (CP) is a histologically benign tumor with high mortality and morbidity. Although surgical treatment is essential in managing CP, the best surgical approach is debated. A retrospective cohort of 117 patients with adult-onset CP (AOCP) treated between 2018 and 2020 in Beijing Tiantan Hospital was identified and examined. The effects of traditional craniotomy (TC) and endoscopic endonasal transsphenoidal surgery (EETS) on the extent of surgical resection, hypothalamic involvement (HI), postoperative endocrine function, and postoperative weight were compared in the cohort. The cohort comprised 43 males and 74 females, divided into the TC (n = 59) and EETS (n = 58) groups. The EETS group possessed a higher rate of gross total resection (GTR) (adjusted odds ratio (aOR) = 4.08, p = 0.029) and improved HI (aOR = 2.58, p = 0.041) than the TC group. Worse postoperative HI was only observed in the TC group (5 patients). The EETS was associated with fewer adverse hormonal outcomes, including posterior pituitary dysfunction (aOR = 0.386, p = 0.040) and hypopituitarism (aOR = 0.384, p = 0.031). Additionally, multivariate logistic regression analysis confirmed that EETS was related to fewer cases of weight gain >5% (aOR = 0.376, p = 0.034), significant weight change (aOR = 0.379, p = 0.022), and postoperative obesity (aOR = 0.259, p = 0.032). Compared to TC, EETS shows advantages in accomplishing GTR, hypothalamus protection, postoperative endocrine function reservation, and postoperative weight control. These data suggest that the EETS deserves more application in managing patients with AOCP