‘Healthmania’ Diet, Supplements and the Pursuit of Health in America and Britain c. 1945-1980.

This thesis explores the history of healthy eating in the mid-to-late twentieth century, providing insight into the roots of contemporary anxieties about healthy lifestyles, dieting, and the prevention of chronic disease in the UK and the US. This thesis argues that during the post-war decades, British and American societies experienced a fundamental shift that enabled new forms of cultural preoccupations about health and diet to flourish. This shift created an obsession within the media, science and society about safeguarding good health, youth and vitality, especially through dieting, specific foods, and the ingestion of supplements. This shift was enabled by the simultaneous promotion and representation of healthy eating as a solution to chronic diseases, by neoromantic notions of health, by anxieties about modern living, but also by the growth of ideas around individual agency and responsibility for health. Drawing on a rich source base of self-help books, newspapers and magazines, advertisements, medical journals and comic books, chapters of this thesis explore the ways in which contemporary obsessions about diet and health were promoted, reported on and experienced in everyday life. Examining health obsessions in relation to gendered approaches to food and broader post-war concerns about the impact of modernity on health and lifestyle, on the valorisation of slim bodies and youth, and on chronic disease prevention and productivity, this thesis offers new perspectives on the multifaceted interactions between self-help advice literature, newspapers and magazines, mainstream medical thought, and comic books during the postwar decades.Wellcome TrustWellcome Trus

RELINE: Point-of-Interest Recommendations using Multiple Network Embeddings

The rapid growth of users' involvement in Location-Based Social Networks (LBSNs) has led to the expeditious growth of the data on a global scale. The need of accessing and retrieving relevant information close to users' preferences is an open problem which continuously raises new challenges for recommendation systems. The exploitation of Points-of-Interest (POIs) recommendation by existing models is inadequate due to the sparsity and the cold start problems. To overcome these problems many models were proposed in the literature, but most of them ignore important factors such as: geographical proximity, social influence, or temporal and preference dynamics, which tackle their accuracy while personalize their recommendations. In this work, we investigate these problems and present a unified model that jointly learns users and POI dynamics. Our proposal is termed RELINE (REcommendations with muLtIple Network Embeddings). More specifically, RELINE captures: i) the social, ii) the geographical, iii) the temporal influence, and iv) the users' preference dynamics, by embedding eight relational graphs into one shared latent space. We have evaluated our approach against state-of-the-art methods with three large real-world datasets in terms of accuracy. Additionally, we have examined the effectiveness of our approach against the cold-start problem. Performance evaluation results demonstrate that significant performance improvement is achieved in comparison to existing state-of-the-art methods

What we talk about when we talk about "global mindset": managerial cognition in multinational corporations

Recent developments in the global economy and in multinational corporations have placed significant emphasis on the cognitive orientations of managers, giving rise to a number of concepts such as “global mindset” that are presumed to be associated with the effective management of multinational corporations (MNCs). This paper reviews the literature on global mindset and clarifies some of the conceptual confusion surrounding the construct. We identify common themes across writers, suggesting that the majority of studies fall into one of three research perspectives: cultural, strategic, and multidimensional. We also identify two constructs from the social sciences that underlie the perspectives found in the literature: cosmopolitanism and cognitive complexity and use these two constructs to develop an integrative theoretical framework of global mindset. We then provide a critical assessment of the field of global mindset and suggest directions for future theoretical and empirical research

Regioisomeric and substituent effects upon the outcome of the reaction of 1-borodienes with nitrosoarene compounds

A study of the reactivity of 1-borodienes with nitrosoarene compounds has been carried out showing an outcome that differs according to the hybridization state of the boron moiety. Using an sp2 boron substituent, a one-pot hetero-Diels–Alder/ring contraction cascade occurred to afford N-arylpyrroles with low to good yields depending on the electronic properties of the substituents on the borodiene, whereas an sp3 boron substituent led to the formation of stable boro-oxazines with high regioselectivity in most of the cases, in moderate to good yields. 1H and 11B NMR studies on two boro-oxazine regioisomers showed that selective deprotection can be performed. Formation of either the pyrrole or the furan derivative is pH- and regioisomer-structure-dependent. The results obtained, together with previous B3LYP calculations, support mechanistic proposals which suggest that pyrrole, or furan, formation proceeds via oxazine formation, followed by a boryl rearrangement and an intramolecular addition–elimination sequence

Outcomes of the “BRCA Quality Improvement Dissemination Program”: An Initiative to Improve Patient Receipt of Cancer Genetics Services at Five Health Systems

OBJECTIVE: A quality improvement initiative (QII) was conducted with five community-based health systems\u27 oncology care centers (sites A-E). The QII aimed to increase referrals, genetic counseling (GC), and germline genetic testing (GT) for patients with ovarian cancer (OC) and triple-negative breast cancer (TNBC). METHODS: QII activities occurred at sites over several years, all concluding by December 2020. Medical records of patients with OC and TNBC were reviewed, and rates of referral, GC, and GT of patients diagnosed during the 2 years before the QII were compared to those diagnosed during the QII. Outcomes were analyzed using descriptive statistics, two-sample t-test, chi-squared/Fisher\u27s exact test, and logistic regression. RESULTS: For patients with OC, improvement was observed in the rate of referral (from 70% to 79%), GC (from 44% to 61%), GT (from 54% to 62%) and decreased time from diagnosis to GC and GT. For patients with TNBC, increased rates of referral (from 90% to 92%), GC (from 68% to 72%) and GT (81% to 86%) were observed. Effective interventions streamlined GC scheduling and standardized referral processes. CONCLUSION: A multi-year QII increased patient referral and uptake of recommended genetics services across five unique community-based oncology care settings

Charitable Giving and Lay Morality: Understanding Sympathy, Moral Evaluations and Social Positions

This paper examines how charitable giving offers an example of lay morality, reflecting people’s capacity for fellow-feeling, moral sentiments, personal reflexivity, ethical dispositions, moral norms and moral discourses. Lay morality refers to how people should treat others and be treated by them, matters that are important for their subjective and objective well-being. It is a first person evaluative relation to the world (about things that matter to people). While the paper is sympathetic to the ‘moral boundaries’ approach, which seeks to address the neglect of moral evaluations in sociology, it reveals this approach to have some shortcomings. The paper argues that although morality is always mediated by cultural discourses and shaped by structural factors, it also has a universalising character because people have fellow-feelings, shared human conditions, and have reason to value

A new protocol for a regioselective aldol condensation as an alternative convenient synthesis of β-ketols and α,β-unsaturated ketones

A general and convenient synthesis of β-ketols and α,β-alkenones has been achieved by a Knoevenagel condensation of a β-ketoacid with an aldehyde in aqueous medium. Saponification of a β-ketoester by an aqueous KOH 10% solution gives the potassium salt of the β-ketoacid, which is condensed in situ with an aldehyde at pH 7.8-8.0, at 60 °C for 5-6 h. The intermediate β-ketocarboxylate is smoothly decarboxylated in the reaction medium, giving the β-ketol in high yield (75-90%). Acidification of the reaction mixture at pH 1 and heating at 70 °C under vigorous stirring for 6 h, leads directly to the corresponding α,β-unsaturated ketone in good yield (65-75%)