A clinical evaluation of the Hydrocurve and Naturvue hydrogel contact lenses

Seven patients were fit with two types of hydrogel lenses. Right eyes were fit with Naturvue lenses and left eyes were fit with Hydrocurve II lenses. Each patient was followed for approximately two months to determine which lens was performing better based on several criteria. At the end of the study it was found that Hydrocurve II performed better for three patients, Naturvue performed better for two, and both lenses performed equally well on the remaining two

Wildlife Benefits of Switchgrass Production in Kentucky

Switchgrass (Panicum virgatum) is a warm-season perennial grass native to much of the United States including Kentucky (USDA). Switchgrass can be grown on marginal soils and regularly produces high biomass yields (4 to 8 tons of dry matter per acre) in Kentucky. Switchgrass varieties are broadly classified into two ecotypes: lowland and upland. Lowland varieties, such as ‘Alamo,’ typically produce higher yields, while upland varieties, such as ‘Cave-in-Rock’ and ‘Kanlow,’ generally have higher forage quality

Novel Approaches to Developing On-Farm Biomass Production Systems

Energy security and climate change are issues facing many countries today. Finding clean, renewable fuel sources has provided a challenge to look beyond the obvious and search for new ways to use old resources. Switchgrass (Panicum virgatum L.) is a warm season grass native to many parts of the United States. In 2007, the University of Kentucky (UK) College of Agriculture started a collaborative project with the UK Cooperative Extension, farmers in northern Kentucky, Kentucky Forage and Grassland Council and East Kentucky Power Cooperative to explore and demonstrate how switchgrass can be grown, harvested and utilized in an economical and environmentally friendly way (Greenwell 2012a,b). This pilot project was funded by the KY Agricultural Development Fund and successfully established 60 ha of switchgrass between 2007-2011 and produced \u3e 500 t of biomass that was combusted for electricity production. Switchgrass was chosen as the biomass crop of choice for this area for a variety of reasons. It can be grown on marginal soils that are not well suited to row crops. It produces high yields with relatively low inputs and can be harvested with equipment that is common on typical US farms. Because it is a native grass, there is little concern of it becoming invasive and it provides wildlife habitat for local animal species. Additionally, when harvested at a vegetative stage, it produces high quality forage

Neuropathologic Burden and Dementia in Nonagenarians and Centenarians

Background and objectivesThe aim of this study was to compare 2 large clinicopathologic cohorts of participants aged 90+ and to determine whether the association between neuropathologic burden and dementia in these older groups differs substantially from those seen in younger-old adults.MethodsAutopsied participants from The 90+ Study and Adult Changes in Thought (ACT) Study community-based cohort studies were evaluated for dementia-associated neuropathologic changes. Associations between neuropathologic variables and dementia were assessed using logistic or linear regression, and the weighted population attributable fraction (PAF) per type of neuropathologic change was estimated.ResultsThe 90+ Study participants (n = 414) were older (mean age at death = 97.7 years) and had higher amyloid/tau burden than ACT <90 (n = 418) (mean age at death = 83.5 years) and ACT 90+ (n = 401) (mean age at death = 94.2 years) participants. The ACT 90+ cohort had significantly higher rates of limbic-predominant age-related TDP-43 encephalopathy (LATE-NC), microvascular brain injury (μVBI), and total neuropathologic burden. Independent associations between individual neuropathologic lesions and odds of dementia were similar between all 3 groups, with the exception of μVBI, which was associated with increased dementia risk in the ACT <90 group only (odds ratio 1.5, 95% CI 1.2-1.8, p < 0.001). Weighted PAF scores indicated that eliminating μVBI, although more prevalent in ACT 90+ participants, would have little effect on dementia. Conversely, eliminating μVBI in ACT <90 could theoretically reduce dementia at a similar rate to that of AD neuropathologic change (weighted PAF = 6.1%, 95% CI 3.8-8.4, p = 0.001). Furthermore, reducing LATE-NC in The 90+ Study could potentially reduce dementia to a greater degree (weighted PAF = 5.1%, 95% CI 3.0-7.3, p = 0.001) than either ACT cohort (weighted PAFs = 1.69, 95% CI 0.4-2.7).DiscussionOur results suggest that specific neuropathologic features may differ in their effect on dementia among nonagenarians and centenarians from cohorts with different selection criteria and study design. Furthermore, microvascular lesions seem to have a more significant effect on dementia in younger compared with older participants. The results from this study demonstrate that different populations may require distinct dementia interventions, underscoring the need for disease-specific biomarkers

APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease

Apolipoprotein E4 (APOE4) genotype is the strongest genetic risk factor for late-onset Alzheimer disease and confers a proinflammatory, neurotoxic phenotype to microglia. Here, we tested the hypothesis that bone marrow cell APOE genotype modulates pathological progression in experimental Alzheimer disease. We performed bone marrow transplants (BMT) from green fluorescent protein–expressing human APOE3/3 or APOE4/4 donor mice into lethally irradiated 5-month-old APPswe/PS1ΔE9 mice. Eight months later, APOE4/4 BMT–recipient APPswe/PS1ΔE9 mice had significantly impaired spatial working memory and increased detergent-soluble and plaque Aβ compared with APOE3/3 BMT–recipient APPswe/PS1ΔE9 mice. BMT-derived microglia engraftment was significantly reduced in APOE4/4 recipients, who also had correspondingly less cerebral apoE. Gene expression analysis in cerebral cortex of APOE3/3 BMT recipients showed reduced expression of tumor necrosis factor-α and macrophage migration inhibitory factor (both neurotoxic cytokines) and elevated immunomodulatory IL-10 expression in APOE3/3 recipients compared with those that received APOE4/4 bone marrow. This was not due to detectable APOE-specific differences in expression of microglial major histocompatibility complex class II, C-C chemokine receptor (CCR) type 1, CCR2, CX3C chemokine receptor 1 (CX3CR1), or C5a anaphylatoxin chemotactic receptor (C5aR). Together, these findings suggest that BMT-derived APOE3-expressing cells are superior to those that express APOE4 in their ability to mitigate the behavioral and neuropathological changes in experimental Alzheimer disease

Manipulation of Magnetic Dipole Emission from Eu 3+ with Mie-Resonant Dielectric Metasurfaces

Mie-resonant high-index dielectric nanoparticles and metasurfaces have been suggested as a viable platform for enhancing both electric and magnetic dipole transitions of fluorescent emitters. While the enhancement of the electric dipole transitions by such dielectric nanoparticles has been demonstrated experimentally, the case of magnetic-dipole transitions remains largely unexplored. Here, we study the enhancement of spontaneous emission of Eu3+ ions, featuring both electric and magnetic-dominated dipole transitions, by dielectric metasurfaces composed of Mie-resonant silicon nanocylinders. By coating the metasurfaces with a layer of an Eu3+ doped polymer, we observe an enhancement of the Eu3+ emission associated with the electric (at 610 nm) and magnetic-dominated (at 590 nm) dipole transitions. The enhancement factor depends systematically on the spectral proximity of the atomic transitions to the Mie resonances as well as their multipolar order, both controlled by the nanocylinder size. Importantly, the branching ratio of emission via the electric or magnetic transition channel can be modified by carefully designing the metasurface, where the magnetic dipole transition is enhanced more than the electric transition for cylinders with radii of about 130 nm. We confirm our observations by numerical simulations based on the reciprocity principle. Our results open new opportunities for bright nanoscale light sources based on magnetic transitions.Financial support by the Thuringian State Government within its ProExcellence initiative (ACP2020) and the German Research Foundation (STA 1426/2-1) is gratefully acknowledged. K.E.C., D.N.N., and Y.S.K. acknowledge the support by the Australian Research Council (DP150103733). Y.S.K. acknowledges a support from the Alexander von Humboldt Foundation. S.N. acknowledges financial support by the Karlsruhe School of Optics and Photonics and by the DFG Priority Programm 1839 Tailored Disorder. The authors also acknowledge their participation in the Erasmus Mundus NANOPHI project, contract number 2013 5659/002- 001. N.N., M.A.N., and S.M. would like to acknowledge the support by NSF EiR grant # 1830886

CO, CI and CII observations of NGC 7023

We present new data on the photodissociation regions associated with the reflection nebula NGC7023. 13CO(3-2) emission, delineates a molecular cloud containing a cavity largely devoid of molecular gas around this star. Neutral carbon is closely associated with the 13CO emission while ionized carbon is found inside and at the edges of the cavity. The ionized carbon appears to be, at least in part, associated with HI. We have mapped the northern and southern rims in 12CO(6-5) emission and found a good association with the H2 rovibrational emission, though the warm CO gas permeates a larger fraction of the molecular cloud than the vibrationally excited H2. The results are compared with PDR models. We suggest that a second PDR has been created at the surface of the molecular cloud by the scattered radiation from HD 200775. This second PDR produces a layer of atomic carbon at the surface of the sheet, which increases the predicted [C]/[CO] abundance ratio to 10%, close to the observed value.Comment: 34 pages, 8 figure

Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism

Blood-based bioenergetic profiling provides a minimally invasive assessment of mitochondrial health shown to be related to key features of aging. Previous studies show that blood cells recapitulate mitochondrial alterations in the central nervous system under pathological conditions, including the development of Alzheimer’s disease. In this study of nonhuman primates, we focus on mitochondrial function and bioenergetic capacity assessed by the respirometric profiling of monocytes, platelets, and frontal cortex mitochondria. Our data indicate that differences in the maximal respiratory capacity of brain mitochondria are reflected by CD14+ monocyte maximal respiratory capacity and platelet and monocyte bioenergetic health index. A subset of nonhuman primates also underwent [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) imaging to assess brain glucose metabolism. Our results indicate that platelet respiratory capacity positively correlates to measures of glucose metabolism in multiple brain regions. Altogether, the results of this study provide early evidence that blood-based bioenergetic profiling is related to brain mitochondrial metabolism. While these measures cannot substitute for direct measures of brain metabolism, provided by measures such as FDG-PET, they may have utility as a metabolic biomarker and screening tool to identify individuals exhibiting systemic bioenergetic decline who may therefore be at risk for the development of neurodegenerative diseases