4,793 research outputs found
Isolation, purification, and full NMR assignments of cyclopamine from Veratrum californicum
The Hedgehog signaling pathway is essential for embryogenesis and for tissue homeostasis in the adult. However, it may induce malignancies in a number of tissues when constitutively activated, and it may also have a role in other forms of normal and maladaptive growth. Cyclopamine, a naturally occurring steroidal alkaloid, specifically inhibits the Hedgehog pathway by binding directly to Smoothened, an important Hedgehog response element. To use cyclopamine as a tool to explore and/or inhibit the Hedgehog pathway in vivo, a substantial quantity is required, and as a practical matter cyclopamine has been effectively unavailable for usage in animals larger than mice
Air Pollution Exposure Assessment for Epidemiologic Studies of Pregnant Women and Children: Lessons Learned from the Centers for Children’s Environmental Health and Disease Prevention Research
The National Children’s Study is considering a wide spectrum of airborne pollutants that are hypothesized to potentially influence pregnancy outcomes, neurodevelopment, asthma, atopy, immune development, obesity, and pubertal development. In this article we summarize six applicable exposure assessment lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research that may enhance the National Children’s Study: a) Selecting individual study subjects with a wide range of pollution exposure profiles maximizes spatial-scale exposure contrasts for key pollutants of study interest. b) In studies with large sample sizes, long duration, and diverse outcomes and exposures, exposure assessment efforts should rely on modeling to provide estimates for the entire cohort, supported by subject-derived questionnaire data. c) Assessment of some exposures of interest requires individual measurements of exposures using snapshots of personal and microenvironmental exposures over short periods and/or in selected microenvironments. d) Understanding issues of spatial–temporal correlations of air pollutants, the surrogacy of specific pollutants for components of the complex mixture, and the exposure misclassification inherent in exposure estimates is critical in analysis and interpretation. e) “Usual” temporal, spatial, and physical patterns of activity can be used as modifiers of the exposure/outcome relationships. f) Biomarkers of exposure are useful for evaluation of specific exposures that have multiple routes of exposure. If these lessons are applied, the National Children’s Study offers a unique opportunity to assess the adverse effects of air pollution on interrelated health outcomes during the critical early life period
Kinks Dynamics in One-Dimensional Coupled Map Lattices
We examine the problem of the dynamics of interfaces in a one-dimensional
space-time discrete dynamical system. Two different regimes are studied : the
non-propagating and the propagating one. In the first case, after proving the
existence of such solutions, we show how they can be described using Taylor
expansions. The second situation deals with the assumption of a travelling wave
to follow the kink propagation. Then a comparison with the corresponding
continuous model is proposed. We find that these methods are useful in simple
dynamical situations but their application to complex dynamical behaviour is
not yet understood.Comment: 17pages, LaTex,3 fig available on cpt.univ-mrs.fr directory
pub/preprints/94/dynamical-systems/94-P.307
Hyperfine Fields in an Ag/Fe Multilayer Film Investigated with 8Li beta-Detected Nuclear Magnetic Resonance
Low energy -detected nuclear magnetic resonance (-NMR) was used
to investigate the spatial dependence of the hyperfine magnetic fields induced
by Fe in the nonmagnetic Ag of an Au(40 \AA)/Ag(200 \AA)/Fe(140 \AA) (001)
magnetic multilayer (MML) grown on GaAs. The resonance lineshape in the Ag
layer shows dramatic broadening compared to intrinsic Ag. This broadening is
attributed to large induced magnetic fields in this layer by the magnetic Fe
layer. We find that the induced hyperfine field in the Ag follows a power law
decay away from the Ag/Fe interface with power , and a field
extrapolated to T at the interface.Comment: 5 pages, 4 figure. To be published in Phys. Rev.
-NMR of Isolated Li Implanted into a Thin Copper Film
Depth-controlled -NMR was used to study highly spin-polarized Li
in a Cu film of thickness 100 nm deposited onto a MgO substrate. The positive
Knight Shifts and spin relaxation data show that Li occupies two sites at
low temperatures, assigned to be the substitutional () and octahedral ()
interstitial sites. Between 50 to 100 K, there is a site change from to
. The temperature dependence of the Knight shifts and spin-lattice
relaxation rates at high temperatures, i.e. when all the Li are in the
site, is consistent with the Korringa Law for a simple metal.Comment: Accepted for publication in Phys. Rev.
Angle-dependent normalization of neutron-proton differential cross sections
Systematic errors in the database of differential cross sections below
350 MeV are studied. By applying angle-dependent normalizations with the help
of the energy-dependent Nijmegen partial-wave analysis PWA93 the
-values of some seriously flawed data sets can be reduced significantly
at the expense of a few degrees of freedom. It turns out that in these special
cases the renormalized data sets can be made statistically acceptable such that
they do not have to be discarded any longer in partial-wave analyses of the
two-nucleon scattering data.Comment: 11 pages, 1 figure; expanded versio
Existence and Stability of Steady Fronts in Bistable CML
We prove the existence and we study the stability of the kink-like fixed
points in a simple Coupled Map Lattice for which the local dynamics has two
stable fixed points. The condition for the existence allows us to define a
critical value of the coupling parameter where a (multi) generalized
saddle-node bifurcation occurs and destroys these solutions. An extension of
the results to other CML's in the same class is also displayed. Finally, we
emphasize the property of spatial chaos for small coupling.Comment: 18 pages, uuencoded PostScript file, J. Stat. Phys. (In press
An Educational Program for Blind Infants
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68635/2/10.1177_002246696900300201.pd
Persistent Spin Dynamics in the V Molecular Nano-Magnet
We present muon spin lattice relaxation measurements in the V15 spin 1/2
molecular nano-magnet. We find that the relaxation rate in low magnetic fields
(<5 kG) is temperature independent below ~10 K, implying that the molecular
spin is dynamically fluctuating down to 12 mK. These measurements show that the
fluctuation time increases as the temperature is decreased and saturates at a
value of ~6 nsec at low temperatures. The fluctuations are attributed to V15
molecular spin dynamics perpendicular to the applied magnetic field direction,
induced by coupling between the molecular spin and nuclear spin bath in the
system.Comment: Accepted for publication in Phys. Rev. B, 5 pages, 5 figur
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