Brain Alterations and Mini-Mental State Examination in Patients with Progressive Supranuclear Palsy: Voxel-Based Investigations Using 18F-Fluorodeoxyglucose Positron Emission Tomography and Magnetic Resonance Imaging

Background/Aims: The aim of this study was to compare differences in morphological and functional changes in brain regions in individual patients with progressive supranuclear palsy (PSP) and correlate their Mini-Mental State Examination (MMSE) score with anatomy and function using magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods: Sixteen PSP patients and 20 age-matched healthy volunteers underwent FDG-PET and 3-dimensional MRI. Gray matter, white matter and metabolic activity were compared between patients and normal controls. In addition, possible correlations between the MMSE score and brain function/anatomy were examined. Results: The PSP group had reduced cerebral glucose metabolism, and lower gray and white matter volumes in the frontal lobes and midbrain compared with normal controls. In PSP subjects, the metabolic changes observed in the PET scans were greater than the loss in gray and white matter observed in the MRI scans. The MMSE scores were positively correlated with volume and FDG uptake in the frontal lobe. Conclusion: FDG-PET is a more effective tool in the diagnosis of PSP than MRI. Atrophy and hypometabolism in the frontal lobe are as important as in the basal midbrain for differentiating PSP patients who primarily exhibit cognitive dysfunction from normal controls

Can Superflares Occur on Our Sun?

Recent observations of solar type stars with the Kepler satellite by Maehara et al. have revealed the existence of superflares (with energy of 10^33 - 10^35 erg) on Sun-like stars, which are similar to our Sun in their surface temperature (5600 K - 6000 K) and slow rotation (rotational period > 10 days). From the statistical analysis of these superflares, it was found that superflares with energy 10^34 erg occur once in 800 years and superflares with 10^35 erg occur once in 5000 years on Sun-like stars. In this paper, we examine whether superflares with energy of 10^33 - 10^35 erg could occur on the present Sun through the use of simple order-of-magnitude estimates based on current ideas relating to the mechanisms of the solar dynamo.Comment: Accepted by Publ. Astron. Soc. Japan on Dec. 6, 2012 (to be published on PASJ vol. 65, No. 3, (2013) June 25