Suzaku Observation of Abell 1555 and Abell 1558: Searching for Non-thermal Emission from Large Scale Structure Formation

We report X-ray observations of two galaxy clusters Abell 1555 and Abell 1558 with Suzaku, which are included in a large scale filamentary structure and a supercluster, to search for non-thermal emission driven by shocks produced in structure formation. These two clusters are detected by Suzaku/XIS for the first time in the X-ray band of 0.5-7 keV. No significant flux is detected by HXD in the energy band of 13-40 keV, and upper limits are reported. From the analysis of the XIS data, we find that the spectrum of A1555 is fit by a thermal plus power-law model, significantly better than a single-temperature pure thermal spectrum. If this power-law component is due to inverse-Compton scattering, the fraction of total baryon energy imparted to non-thermal electrons is consistent with the typical value inferred from the observation of other clusters. However, other scenarios (e.g., under lying AGNs, multi-temperature thermal models) cannot be excluded and further investigation of this system is desired. Basic physical properties of A1555 (e.g., total mass) are also reported.Comment: 10 pages, 6 figures. Accepted for publication in the PAS

Building primary care in Japan: Literature review.

Japan's health system is well known for achieving one of the world's highest life expectancy with universal health coverage. However, the country now faces challenges of a rapidly aging population and changes in patterns and burden of disease. Primary care is an important component of a well-functioning health system. In Japan, primary care services are provided in both the community and hospital settings. The distinction between primary and secondary care may not always be clear. This review is based on the framework from the 2015 WHO publication on primary care systems in Europe. Our aim is to describe the journey of primary care in Japan, with its past, present, and future as a valuable addition to the academic English literature. We also hope that this article would inspire readers outside of Japan who might face similar issues in their respective countries

Computed tomography findings of intersigmoid hernia

Purpose: To evaluate the computed tomography findings of intersigmoid hernias. Material and methods: Between April 2010 and March 2018, 7 patients who were surgically diagnosed with intersigmoid hernia in 3 institutions were enrolled in this study. Two radiologists evaluated imaging findings for the herniated small bowel, the distance between the occlusion point and bifurcation of the left common iliac artery, and the anatomic relationship with adjacent organs. Results: All patients were male, and their mean age (standard deviation, range) was 61.0 (13.5, 36-85) years. The mean size of the bowel loops was 5.2 (1.3, 4.0-8.3) cm in the caudal direction, 3.6 (0.8, 2.5-5.1) cm in the lateral, and 3.4 (0.6, 2.5-4.7) cm in the anterior-posterior direction. The volume was 37.9 (27.8, 15.6-103.0) cm3 approximated by an ellipse, and 24.0 (17.7, 9.9-65.6) cm3 approximated by a truncated cone. The obstruction point was located 3.6 (0.6, 2.8-4.7) cm inferior to the bifurcation of the left common iliac artery. In all cases, the small bowel ran under the point at which the inferior mesenteric vessels bifurcated to the superior rectal vessels and the sigmoid vessels and formed a sac-like appearance between the left psoas muscle and the sigmoid colon. The ureter ran dorsal to the point of the bowel stenosis, and the left gonadal vein ran outside the small bowel loops. Conclusions: All cases showed common imaging findings, which may be characteristic of men's intersigmoid hernia. In addition, the fossa's position was lower, and the size was larger than in the previous study, which may be a risk factor

Psychosocial twin cohort studies in Japan: the Keio Twin Research Center (KoTReC)

The Keio Twin Research Center (KoTReC) was established in 2009 at Keio University to combine two longitudinal cohort projects — the Keio Twin Study (KTS) for adolescence and adulthood and the Tokyo Twin Cohort Project (ToTCoP) for infancy and childhood. KoTReC also conducted a two-time panel study of self-control and psychopathology in twin adolescence in 2012 and 2013 and three independent anonymous cross-sectional twin surveys (ToTcross) before 2012 — the ToTCross, the Junior and Senior High School Survey and the High School Survey. This article introduces the recent research designs of KoTReC and its publications

A robot uses its own microphone to synchronize its steps to musical beats while scatting and singing

Abstract—Musical beat tracking is one of the effective technologies for human-robot interaction such as musical ses-sions. Since such interaction should be performed in various environments in a natural way, musical beat tracking for a robot should cope with noise sources such as environmental noise, its own motor noises, and self voices, by using its own microphone. This paper addresses a musical beat tracking robot which can step, scat and sing according to musical beats by using its own microphone. To realize such a robot, we propose a robust beat tracking method by introducing two key techniques, that is, spectro-temporal pattern matching and echo cancellation. The former realizes robust tempo estimation with a shorter window length, thus, it can quickly adapt to tempo changes. The latter is effective to cancel self noises such as stepping, scatting, and singing. We implemented the proposed beat tracking method for Honda ASIMO. Experimental results showed ten times faster adaptation to tempo changes and high robustness in beat tracking for stepping, scatting and singing noises. We also demonstrated the robot times its steps while scatting or singing to musical beats. I

Suzaku Observation of Abell 1689: Anisotropic Temperature and Entropy Distributions Associated with the Large-Scale Structure

(Abridged) We present results of Suzaku observations of the intracluster medium (ICM) in Abell 1689, combined with complementary analysis of the SDSS data and weak and strong lensing analysis of Subaru/Suprime-Cam and HST/ACS observations. Faint X-ray emission from the ICM around the virial radius is detected at 4.0 sigma significance. We find anisotropic gas temperature and entropy distributions in cluster outskirts correlated with large-scale structure of galaxies. The high temperature and entropy region in the northeastern (NE) outskirts is connected to an overdense filamentary structure. The outskirt regions in contact with low density void environments have low gas temperatures and entropies, deviating from hydrostatic equilibrium. These results suggest that thermalization of the ICM occurs faster along the filamentary structures than the void regions. A joint X-ray and lensing analysis shows that the hydrostatic mass is $\sim60-90$ of spherical lensing one but comparable to a triaxial halo mass within errors in 0.6r_{2500} \simlt r \simlt 0.8r_{500}, and that it is significantly biased as low as \simlt60% within $0.4r_{2500}$, irrespective of mass models. The thermal gas pressure within $r_{500}$ is, at most, $\sim50$--60% of the total pressure to balance fully the gravity of the spherical lensing mass, and $\sim30$--40% around the virial radius. Although these constitute lower limits when one considers the possible halo triaxiality, these small relative contributions of thermal pressure would require additional sources of pressure, such as bulk and/or turbulent motions.Comment: 24 pages, 15 figures, 9 tables. Accepted for publication in Ap

PE-46 The Design of the Lynx X-Ray Microcalorimeter

Lynx is an x-ray telescope, one of four large satellite mission concepts currently being studied by NASA to be the next astrophysics flagship mission after WFIRST. One of Lynx's three instruments is an imaging spectrometer consisting of an x-ray microcalorimeter behind an X-ray optic with an angular resolution of 0.5 arc-seconds and approximately 3 sq m of area at 1 keV. This instrument will provide unparalleled diagnostics of distant extended structures and in particular will allow the detailed study of the role of cosmic feedback in the evolution of the Universe. We discuss the design and read-out of the of the array configuration including a number of sub-array options for increasing the capabilities to maximize the scientific return of the Lynx observatory

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer

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