A study of high efficiency CO2 refrigerant VRF air conditioning system adopting multi-stage compression cycle

CO2 refrigerant is expected to be use for air conditioners due to its environmental property of GWP = 1, non-flammability and low toxicity and has already been applied to hot water supply system, refrigerators and freezers. However, since cycle COP of CO2 is poorer than that of HFC in applying to air conditioner, it cannot be expected to improve the performance significantly by simply improving the efficiency of a conventional single-stage cycle and components consisting of the cycle.  Therefore, it is important to improve the cycle efficiency, especially in the performance of cooling which is a weak point of CO2. Challenges also lie in reducing weight of components such as compressor and heat exchangers resulted in weight gain to resist high pressure and to achieve high efficiency in the system. In this study, a prototype of CO2 refrigerant VRF air conditioning system is constructed and evaluates the performance. The system is adopting the four-stage compression cycle applying a new type compressor and heat exchangers and so on aimed for high efficiency cycle and reducing weight As a result of the evaluation, it is confirmed that CO2 cycle performance can be improved in similar extent to HFC refrigerant cycle. On the other hand, this high efficiency cycle consists of a lot of components and becomes more complex than HFC refrigerant cycle; therefore the size and weight of outdoor unit increases to house these components. Further technical development will be necessary to overcome these weaknesses

Evaluation and Optimization of System Performance using HFO-mix Refrigerants for VRF and Mini-split Air-Conditioner

Global demand for air conditioning is expected to increase continuously. In order to minimize the impact on the climate as a total amount of CO2 equivalent, it is essential to continue to search for better refrigerants. On the other hand, product size and cost are important factors in providing value to users. This time, while using the experiment result of the mini-split type air-conditioner reported in the past, in addition, we conducted a new experiment on multi-type VRF air-conditioner. Then, the difference in COP performance between R-410A and alternative candidate refrigerants was evaluated. In addition, we studied the product design using R-452 B, R-454 B by simulation and compare the size when the performance is made identical by changing the system specifications with alternative refrigerant candidates. As a result, common results were obtained in both systems. It was found that R-452B and R-454B have better performance than R-410A. On the other hand, it was found that these refrigerants need to increase both the indoor heat exchanger and the outdoor heat exchanger to 120% in order to obtain the same performance as R-32

Severe Hemolytic Jaundice in a Neonate with a Novel COL4A1 Mutation

We report our experience with a preterm infant with severe hemolytic jaundice who required exchange transfusion just after birth. The patient was negative for alloimmune hemolysis as a result of maternal–fetal blood type incompatibility, and tests for inherited defects in erythrocyte metabolism, membrane function, and hemoglobin synthesis were normal. We also performed a bone marrow examination, but could not identify the cause of hemolysis. The patient had several other complications, including porencephaly, epilepsy, elevated serum levels of creatine kinase, and persistent microscopic hematuria. Later, we detected a genetic mutation in COL4A1, which was recently found to be associated with hemolytic anemia. We therefore believe that all of the patient's clinical features, including hemolytic anemia, were due to the mutation in COL4A1. Genetic testing for COL4A1 mutations is recommended in neonates who exhibit hemolytic disease of unknown etiology, especially when other complications compatible with COL4A1-related disorders are present

Sequential Coordination between Lingual and Pharyngeal Pressures Produced during Dry Swallowing

The aim of this study was to investigate oropharyngeal pressure flow dynamics during dry swallowing in ten healthy subjects. Tongue pressure (TP) was measured using a sensor sheet system with five measuring points on the hard palate, and pharyngeal pressure (PP) was measured using a manometric catheter with four measuring points. The order and correlations of sequential events, such as onset, peak, and offset times of pressure production, at each pressure measuring point were analyzed on the synchronized waveforms. Onset of TP was earlier than that of PP. The peak of TP did not show significant differences with the onset of PP, and it was earlier than that of PP. There was no significant difference between the offset of TP and PP. The onset of PP was temporally time-locked to the peak of TP, and there was an especially strong correlation between the onset of PP and TP at the posterior-median part on the hard palate. The offset of PP was temporally time-locked to that of TP. These results could be interpreted as providing an explanation for the generation of oropharyngeal pressure flow to ensure efficient bolus transport and safe swallowing