Complete Caudate Lobectomy: Its Definition, Indications, and Surgical Approaches

There are three ways to approach and resect the caudate lobe of the liver, that is; and isolated caudate lobectomy, a combined resection of the liver overlying the caudate lobe, and a transhepatic anterior approach by splitting parenchyma of the liver

Regioselective photoalkylation of 2-cyano-6-methoxynaphthalene by methoxy-substituted 1,2-diarylcyclopropanes

金沢大学理工研究域物質化学系Photoreactions of 2-cyano-6-methoxynaphthalene with methoxy-substituted 1,2-diarylcyclopropanes in benzene give 2-cyano-1-(1,3-diarylpropyl)-6-methoxynaphthalenes. The excellent regioselectivity seen in these processes can be explained by initial formation of singlet exciplexes, in which the dipoles of each component are oriented in opposite directions. © 2009 Elsevier B.V. All rights reserved

Selective Dual-purpose Photocatalysis for Simultaneous H2 Evolution and Mineralization of Organic Compound Enabled by Cr2O3 Barrier Layer Coated on Rh/SrTiO3

Dual-functional photocatalysis for H-2 evolution with the simultaneous mineralization of 4-chlorophenol was achieved under de-aerated conditions using a Cr2O3/Rh/SrTiO3 photocatalyst which has Rh nanoparticles covered with a thin Cr2O3 barrier layer to selectively control and maximize the dual-functional photocatalytic activity.111511Ysciescopu

Src Homology 2–containing 5-Inositol Phosphatase (SHIP) Suppresses an Early Stage of Lymphoid Cell Development through Elevated Interleukin-6 Production by Myeloid Cells in Bone Marrow

The Src homology (SH)2–containing inositol 5-phosphatase (SHIP) negatively regulates a variety of immune responses through inhibitory immune receptors. In SHIP(−/−) animals, we found that the number of early lymphoid progenitors in the bone marrow was significantly reduced and accompanied by expansion of myeloid cells. We exploited an in vitro system using hematopoietic progenitors that reproduced the in vivo phenotype of SHIP(−/−) mice. Lineage-negative marrow (Lin(−)) cells isolated from wild-type mice failed to differentiate into B cells when cocultured with those of SHIP(−/−) mice. Furthermore, culture supernatants of SHIP(−/−) Lin(−) cells suppressed the B lineage expansion of wild-type lineage-negative cells, suggesting the presence of a suppressive cytokine. SHIP(−/−) Lin(−) cells contained more IL-6 transcripts than wild-type Lin(−) cells, and neutralizing anti–IL-6 antibody rescued the B lineage expansion suppressed by the supernatants of SHIP(−/−) Lin(−) cells. Finally, we found that addition of recombinant IL-6 to cultures of wild-type Lin(−) bone marrow cells reproduced the phenotype of SHIP(−/−) bone marrow cultures: suppression of B cell development and expansion of myeloid cells. The results identify IL-6 as an important regulatory cytokine that can suppress B lineage differentiation and drive excessive myeloid development in bone marrow

Effect of Students’ Reflection on their Teaching Practice Experiences: Discussions during Case Conferences in Teaching Practice

The purpose of this study was to clarify the effect of reflecting by student A, who participated in a teaching practice. As a result, the following three points were clarified. First, student A made more comments at case conferences than student teacher B. Moreover, student A made more comments concerning “alternatives” in which students’ reflections appear in case conferences than student teacher B. Second, the students’ reflections at case conferences revealed a commonly shared viewpoint on “teaching skills”. Student A also held the viewpoint of an “approach to the objective” and that the content of the class was appropriate to the goal of the lesson. Regarding the difference between student A and student teacher B, it was suggested that the mentoring received by student A from mentor D during the teaching practice had some degree of influence. Third, both student A and student teacher B has difficulties with “schoolchild understanding” despite mentor D talking at case conferences about this issue. Based on these findings, it is suggested that it is difficult to engage in reflection that enables student to comprehend “schoolchild understanding” in teaching practice

Direct Supply Chain from Forest to House Builder: A Japanese Business Model

AbstractWe developed a direct supply chain from a forest to a house builder for environment-friendly wooden long-life housing based on the “progressive market-in” method. This business model successfully incorporates the external environmental value of the house into its market price.In this paper, we discuss the direct supply chain business model and its environmental effect in Japan, using a micro approach (for individual economic bodies) and a macro approach for the country

Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity

APOBEC3s (A3s) are single-stranded DNA cytosine deaminases that provide innate immune defences against retroviruses and mobile elements. A3s are specific to eutherian mammals because no direct homologs exist at the syntenic genomic locus in metatherian (marsupial) or prototherian (monotreme) mammals. However, the A3s in these species have the likely evolutionary precursors, the antibody gene deaminase AID and the RNA/DNA editing enzyme APOBEC1 (A1). Here, we used cell culture-based assays to determine whether opossum A1 restricts the infectivity of retroviruses including human immunodeficiency virus type 1 (HIV-1) and the mobility of LTR/non-LTR retrotransposons. Opossum A1 partially inhibited HIV-1, as well as simian immunodeficiency virus (SIV), murine leukemia virus (MLV), and the retrotransposon MusD. The mechanism of inhibition required catalytic activity, except for human LINE1 (L1) restriction, which was deamination-independent. These results indicate that opossum A1 functions as an innate barrier to infection by retroviruses such as HIV-1, and controls LTR/non-LTR retrotransposition in marsupials