Ailesel hiperkolesterolemide aferez tedavisi kimlere önerilmelidir?

[No abstract available

Chronic thromboembolic pulmonary hypertension [Kronik tromboembolik pulmoner hipertansiyon]

Although chronic thromboembolic pulmonary hypertension (CTEPH) is a serious disease with high mortality, it is potentially a curable form of pulmonary hypertension. It is thought to develop from organized pulmonary arterial obstructions by single and recurrent pulmonary thromboemboli or from in situ thrombosis. Definitive treatment requires surgical resection of the thromboembolic material. Early diagnosis and pulmonary thromboendarterectomy may improve hemodynamics and functional capacity, and thus survival. Without treatment, progressive pulmonary hypertension, right heart failure, and death will ensue. The purpose of this article is to provide a brief overview of CTEPH, to review current methods of diagnosis, and to summarize the effects of drug therapy and interventions on CTEPH, together with a detailed account on the effects of pulmonary endarterectomy

Egg consumption and cardiovascular health [Yumurta tüketimi ve kardiyovasküler saglik]

PubMed ID: 19875912Egg has been accepted as a symbol of high cholesterol diet for years and its consumption has been a matter of debate for cardiovascular health. Clinical studies have yielded conflicting results, increasing the amplitude of arguments. This article reviews the current literature related to egg consumption and summarizes the merits and demerits of egg consumption on a scientific basis. Current guidelines recommend to restrict dietary cholesterol consumption to 200 mg daily for cardiovascular health. Therefore, when making dietary suggestions especially for patients with cardiovascular disease, diabetes, severe risk factors and hypercholesterolemia, or a family history of premature atherosclerosis, we should keep in mind that an average egg yolk contains >200 mg cholesterol even though its negative effect on serum lipid levels is less than that of other sources of dietary cholesterol

Current approach to the treatment of pulmonary arterial hypertension and our experience in the Cardiology Department Of Medicine Faculty Of Ege University [Pulmoner arteryel hipertansiyon tedavisine güncel yaklaşim ve Ege Üniversitesi Tip Fakültesi Kardiyoloji Klinigi'nin deneyimi]

PubMed ID: 20200464Pulmonary arterial hypertension is a progressive disease marked by increased pulmonary artery resistance leading to right heart failure and has very high mortality. Survival rates have somewhat improved in recent years due to the development of new drugs and early diagnosis. This review aims to summarize the current therapeutic approach to pulmonary arterial hypertension and share our experience at our center

Apoptosis and cardiovascular disease [Apoptozis ve kardiyovasküler hastaliklar]

PubMed ID: 12460831Apoptosis is defined as a genetically programmed cell death. Apoptotic cell death plays an important role both in heart development and cardiac disease. This review deals with the key features of this process. The modification of possible interactions between extrinsic and intrinsic factors affecting the cell during apoptotic process may be of major interest in preventing the progression of cardiovascular disease. Current issues on the pathogenetic role of apoptosis in heart disease and how these knowledge can be applied in clinical usage is also evaluated in this review

Apoptosis and cardiovascular disease [Apoptozis ve kardiyovasküler hastaliklar]

PubMed ID: 12460831Apoptosis is defined as a genetically programmed cell death. Apoptotic cell death plays an important role both in heart development and cardiac disease. This review deals with the key features of this process. The modification of possible interactions between extrinsic and intrinsic factors affecting the cell during apoptotic process may be of major interest in preventing the progression of cardiovascular disease. Current issues on the pathogenetic role of apoptosis in heart disease and how these knowledge can be applied in clinical usage is also evaluated in this review

Seven years of experience in patients with pulmonary arterial hypertension in Ege University Hospital: Diagnostic approach of a single center [Ege Üniversitesi Hastanesi'nde pulmoner arteryel hipertansiyonlu hastalarla 7 yillik deneyimimiz: Tek merkezin tanisal yaklaşimi]

PubMed ID: 18676304Objective: Pulmonary arterial hypertension (PAH) is a term used to define a variety of progressive conditions that have in common, increased pulmonary vascular resistance leading to right heart failure and death. There has been considerable decrease in mortality and morbidity with the advances in PAH treatment over the past decade. However, since there is no epidemiologic study in Turkey, the prevalence of PAH and its importance is not known yet. This study aimed to evaluate the diagnostic clinical experience of Ege University Medical School Cardiology Department with PAH patients. Methods: We evaluated the diagnostic approach to patients referred to our department with the diagnosis of PAH since 2000 by retrospective analysis method. Results: The diagnosis of pulmonary hypertension was definite in 70 patients (mean age 47±16 years, 61% women). Etiology from most prevalent to least was as following: congenital heart diseases (27%), chronic thromboembolic pulmonary hypertension (24%), connective tissue diseases-scleroderma (14%), idiopathic PAH (8%), diastolic dysfunction (3%), pulmonary disease (3%), pulmonary veno-occlusive disease (2%), hepatopulmonary hypertension (1%), and HIV-infection associated PAH (1%). At diagnosis, 68% of patients were in NYHA functional class-III or IV. Six-minute walk test was 263±127m. Mean pulmonary artery pressure was 65±20 mmHg. The prognostic marker pro-BNP (brain natriuretic peptid) level was 3208±4145 pg/ml. Conclusion: Our practice shows that PAH is diagnosed late in the course of the disease in Turkey. This can be overcome with structured management in designated centers with multidisciplinary team-working in a shared care approach. There is also an urgent need for an epidemiological registry in order to determine the burden of PAH in Turkey and increase the awareness of doctors