Spectroscopy of Early F Stars: γ Doradus Candidates and Possible Metallic Shell Stars

We obtained high-resolution spectroscopic observations of 34 γ Doradus candidates. From the red-wavelength spectra, we determined spectral classes, radial velocities, and projected rotational velocities. The spectra of seven late A or early F stars show metallic lines that have composite profiles consisting of a narrow component near the center of a broad line, indicating that they may be shell stars or binaries. Several stars, including HD 152896, HD 173977, HD 175337, and HD 195068/9, show large line profile asymmetries. Two stars, HD 11443 (=α Trianguli) and HD 149420, are ellipsoidal variables and not γ Doradus stars. The percentage of binary systems in our sample may be as high as 74%

10 New γ Doradus and δ Scuti Stars

We present high-resolution spectroscopy and precision photometry of five new γ Doradus and five new δ Scuti variables. The five new γ Doradus variables substantially increase the number of confirmed stars of this class. All 10 stars fall in the spectral class range F0–F2, but they are cleanly separated into two groups by their luminosity and photometric periods. However, the period gap between the γ Doradus and δ Scuti stars is becoming very narrow since we confirm that HD 155154 is a γ Doradus star with the shortest periods reported to date (the shortest of its four periods is ∼0.312 days). We do not find any evidence in our sample for stars exhibiting both δ Scuti– and γ Doradus–type pulsations

Simultaneous photometry and spectroscopy of the newly discovered γ Doradus variable HR 8330=HD 207223

We present BV photometry and simultaneous high-resolution, high signal-to-noise ratio spectroscopy of the newly-discovered γ Doradus variable HR 8330 taken during the 1997 and 1998 observing seasons. We calculate power spectra for the B- and V-band data sets and for the time series defined throughout the observing season at each point across the Fe iiλ4508.289 and the Ti iiλ4501.278 line profiles to search for periodic variability. Period analysis reveals a single, 2.6-d period in both the photometric and the spectroscopic data, with a 237° phase lag between them. Based on the location of HR 8330 in the HR diagram and the characteristics of its photometric and spectroscopic variations, we conclude that HR 8330 is a bona fide γ Doradus-type pulsating variable

HD 62454 and HD 68192: Two New γ Doradus Variables

We present multilongitude, multicolor photometry and simultaneous high-resolution, high signal-to-noise spectroscopy of the newly discovered γ Doradus variables HD 62454 and HD 68192. From combined Johnson and Strömgren data, we are able to identify five independent periods in HD 62454 and two stable periods in HD 68192. The data presented are sufficient to rule out all physically meaningful types of variations, with the one exception of the high-order, low-degree, nonradial gravity-mode pulsations that are believed to be at work in γ Doradus stars. We also find that HD 62454 is a double-lined spectroscopic binary and we present an orbital solution

Gamma Doradus Stars: Defining a New Class of Pulsating Variables

In this paper we describe a new class of pulsating stars, the prototype of which is the bright, early, F-type dwarf, Gamma Doradus. These stars typically have between 1 and 5 periods ranging from 0.4 to 3 days with photometric amplitudes up to 0.1 in Johnson V. The mechanism for these observed variations is high-order, low-degree, non-radial, gravity-mode pulsation. Gamma Doradus stars exhibit variability on a time scale that is an order of magnitude slower than Delta Scuti stars. They may offer additional insight into stellar physics when they are better understood (e.g., they may represent the cool portion of an "iron opacity instability strip" currently formed by the Beta Cephei stars, the SPB stars, and the subdwarf B stars; they may also offer insight into the presence of g-modes in solar-like stars).Comment: 15 pages, 1 ps figure. Accepted for publication in PAS

Impact of Empiric Antimicrobial Therapy on Outcomes in Patients with Escherichia coli and Klebsiella pneumoniae Bacteremia: A Cohort Study

<p>Abstract</p> <p>Background</p> <p>It is unclear whether appropriate empiric antimicrobial therapy improves outcomes in patients with bacteremia due to <it>Escherichia coli </it>or <it>Klebsiella</it>. The objective of this study is to assess the impact of appropriate empiric antimicrobial therapy on in-hospital mortality and post-infection length of stay in patients with <it>Escherichia coli </it>or <it>Klebsiella </it>bacteremia while adjusting for important confounding variables.</p> <p>Methods</p> <p>We performed a retrospective cohort study of adult patients with a positive blood culture for <it>E. coli </it>or <it>Klebsiella </it>between January 1, 2001 and June 8, 2005 and compared in-hospital mortality and post-infection length of stay between subjects who received appropriate and inappropriate empiric antimicrobial therapy. Empiric therapy was defined as the receipt of an antimicrobial agent between 8 hours before and 24 hours after the index blood culture was drawn and was considered appropriate if it included antimicrobials to which the specific isolate displayed <it>in vitro </it>susceptibility. Data were collected electronically and through chart review. Survival analysis was used to statistically assess the association between empiric antimicrobial therapy and outcome (mortality or length of stay). Multivariable Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI).</p> <p>Results</p> <p>Among 416 episodes of bacteremia, 305 (73.3%) patients received appropriate empiric antimicrobial therapy. Seventy-one (17%) patients died before discharge from the hospital. The receipt of appropriate antimicrobial agents was more common in hospital survivors than in those who died (p = 0.04). After controlling for confounding variables, there was no association between the receipt of appropriate empiric antimicrobial therapy and in-hospital mortality (HR, 1.03; 95% CI, 0.60 to 1.78). The median post-infection length of stay was 7 days. The receipt of appropriate antimicrobial agents was not associated with shortened post-infection length of stay, even after controlling for confounding (HR, 1.11; 95% CI 0.86 to 1.44).</p> <p>Conclusion</p> <p>Appropriate empiric antimicrobial therapy for <it>E. coli </it>and <it>Klebsiella </it>bacteremia is not associated with lower in-hospital mortality or shortened post-infection length of stay. This suggests that the choice of empiric antimicrobial agents may not improve outcomes and also provides data to support a randomized trial to test the hypothesis that use (and overuse) of broad-spectrum antibiotics prior to the availability of culture results is not warranted.</p

Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

BACKGROUND:In October 2009 it was reported that 68 of 101 patients with chronic fatigue syndrome (CFS) in the US were infected with a novel gamma retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), a virus previously linked to prostate cancer. This finding, if confirmed, would have a profound effect on the understanding and treatment of an incapacitating disease affecting millions worldwide. We have investigated CFS sufferers in the UK to determine if they are carriers of XMRV. METHODOLOGY:Patients in our CFS cohort had undergone medical screening to exclude detectable organic illness and met the CDC criteria for CFS. DNA extracted from blood samples of 186 CFS patients were screened for XMRV provirus and for the closely related murine leukaemia virus by nested PCR using specific oligonucleotide primers. To control for the integrity of the DNA, the cellular beta-globin gene was amplified. Negative controls (water) and a positive control (XMRV infectious molecular clone DNA) were included. While the beta-globin gene was amplified in all 186 samples, neither XMRV nor MLV sequences were detected. CONCLUSION:XMRV or MLV sequences were not amplified from DNA originating from CFS patients in the UK. Although we found no evidence that XMRV is associated with CFS in the UK, this may be a result of population differences between North America and Europe regarding the general prevalence of XMRV infection, and might also explain the fact that two US groups found XMRV in prostate cancer tissue, while two European studies did not

Multidrug-resistant Acinetobacter Infection Mortality Rate and Length of Hospitalization

Acinetobacter infections have increased and gained attention because of the organism’s prolonged environmental survival and propensity to develop antimicrobial drug resistance. The effect of multidrug-resistant (MDR) Acinetobacter infection on clinical outcomes has not been reported. A retrospective, matched cohort investigation was performed at 2 Baltimore hospitals to examine outcomes of patients with MDR Acinetobacter infection compared with patients with susceptible Acinetobacter infections and patients without Acinetobacter infections. Multivariable analysis controlling for severity of illness and underlying disease identified an independent association between patients with MDR Acinetobacter infection (n = 96) and increased hospital and intensive care unit length of stay compared with 91 patients with susceptible Acinetobacter infection (odds ratio [OR] 2.5, 95% confidence interval [CI] 1.2–5.2 and OR 2.1, 95% CI 1.0–4.3] respectively) and 89 uninfected patients (OR 2.5, 95% CI 1.2–5.4 and OR 4.2, 95% CI 1.5–11.6] respectively). Increased hospitalization associated with MDR Acinetobacter infection emphasizes the need for infection control strategies to prevent cross-transmission in healthcare settings

A Historiometric Examination of Machiavellianism and a New Taxonomy of Leadership

Although researchers have extensively examined the relationship between charismatic leadership and Machiavellianism (Deluga, 2001; Gardner & Avolio, 1995; House & Howell, 1992), there has been a lack of investigation of Machiavellianism in relation to alternative forms of outstanding leadership. Thus, the purpose of this investigation was to examine the relationship between Machiavellianism and a new taxonomy of outstanding leadership comprised of charismatic, ideological, and pragmatic leaders. Using an historiometric approach, raters assessed Machiavellianism via the communications of 120 outstanding leaders in organizations across the domains of business, political, military, and religious institutions. Academic biographies were used to assess twelve general performance measures as well as twelve general controls and five communication specific controls. The results indicated that differing levels of Machiavellianism is evidenced across the differing leader types as well as differing leader orientation. Additionally, Machiavellianism appears negatively related to performance, though less so when type and orientation are taken into account.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project

Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. Results: The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation. Conclusion: This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection