Systematic Evaluation of Applying Space-Filling Curves to Automotive Maneuver Detection

Identifying driving maneuvers plays an essential role on-board vehicles to monitor driving and driver states, as well as off-board to train and evaluate machine learning algorithms for automated driving for example. Maneuvers can be characterized by vehicle kinematics or data from its surroundings including other traffic participants. Extracting relevant maneuvers therefore requires analyzing time-series of (i) structured, multi-dimensional kinematic data, and (ii) unstructured, large data samples for video, radar, or LiDAR sensors. However, such data analysis requires scalable and computationally efficient approaches, especially for non-annotated data. In this paper, we are presenting a maneuver detection approach based on two variants of space-filling curves (Z-order and Hilbert) to detect maneuvers when passing roundabouts that do not use GPS data. We systematically evaluate their respective performance by including permutations of selections of kinematic signals at varying frequencies and compare them with two alternative baselines: All manually identified roundabouts, and roundabouts that are marked by geofences. We find that encoding just longitudinal and lateral accelerations sampled at 10Hz using a Hilbert space-filling curve is already successfully identifying roundabout maneuvers, which allows to avoid the use of potentially sensitive signals such as GPS locations to comply with data protection and privacy regulations like GDPR.Comment: 7 pages, 4 figure

MSDeveloper: A Variability-Guided Methodology for Microservice-Based Development

This article presents a microservice-based development approach, MSDeveloper (Microservices Developer), employing variability management for product configuration through a low-code development environment. The purpose of this approach is to offer a general-purpose environment for the easier development of families of products for different domains: a domain-oriented development environment is suggested, where domain developers and product developers can utilize the environment as a software ecosystem. Thus, genericity is offered through supporting different domains. A domain is populated with feature and process models and microservices in a layered architecture. Feature models drive the product configuration, which affects the process model and the microservice layer. An experimental study was conducted to validate the applicability of the approach and the usability of the development environment. Students from different courses were assigned system modeling projects where they utilized helper tools supporting the provided methodology. Furthermore, professional software developers were consulted about this recommended domain-oriented development environment. Feedback from student projects and professionals’ remarks are analyzed and discussed

Effect of shed blood retransfusion on pulmonary perfusion after total knee arthroplasty: a prospective controlled study

Postoperative shed blood retransfusion (autotransfusion) is a commonly used salvage method following major surgical operations, such as total knee arthroplasty (TKA). The systemic effects of shed blood are still unclear. We studied the effect of residual substances in the retransfused shed blood, on lung perfusion after TKA. Fifteen unilateral and one bilateral TKAs were performed with autotransfusion (the study group) and 15 unilateral and three bilateral TKAs were performed in a control group. Lung X-rays, arterial blood gases (ABG), D-dimer values, and lung perfusion scintigraphies were performed preoperatively and postoperatively. A mean of 300.0 ± 335.6 ml of bank blood was needed in the autotransfusion group and a mean of 685.7 ± 365.5 ml of bank blood was needed in the control group (p=0.001). There was a postoperative segmental perfusion defect at the lateral segment of the superior lobe of the left lung in one patient of the control group and he also had risk factors for thrombosis. Although both groups had a decrease in lung perfusion postoperatively, there were no significant differences among the groups regarding the lung perfusion scintigraphy, chest X-rays, ABG, and D-dimer values. In conclusion, although pulmonary perfusion diminishes following TKA, shed blood retransfusion does not add any risk to pulmonary perfusion

Original Article The prevalence and diagnostic criteria of health-care associated infections in neonatal intensive care units in Turkey: A multicenter point- prevalence study

Background: Healthcare-acquired infections (HAIs) in the neonatal period cause substantial morbidity, mortality, and healthcare costs. Our purpose was to determine the prevalence of HAIs, antimicrobial susceptibility of causative agents, and the adaptivity of the Centres for Disease Control and Prevention (CDC) criteria in neonatal HAI diagnosis

Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors

Exome sequencing analysis of over 2,000 children with complex malformations of cortical development identified five independent (four homozygous and one compound heterozygous) deleterious mutations in KATNB1, encoding the regulatory subunit of the microtubule-severing enzyme Katanin. Mitotic spindle formation is defective in patient-derived fibroblasts, a consequence of disrupted interactions of mutant KATNB1 with KATNA1, the catalytic subunit of Katanin, and other microtubule-associated proteins. Loss of KATNB1 orthologs in zebrafish (katnb1) and flies (kat80) results in microcephaly, recapitulating the human phenotype. In the developing Drosophila optic lobe, kat80 loss specifically affects the asymmetrically dividing neuroblasts, which display supernumerary centrosomes and spindle abnormalities during mitosis, leading to cell cycle progression delays and reduced cell numbers. Furthermore, kat80 depletion results in dendritic arborization defects in sensory and motor neurons, affecting neural architecture. Taken together, we provide insight into the mechanisms by which KATNB1 mutations cause human cerebral cortical malformations, demonstrating its fundamental role during brain development

Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors

Exome sequencing analysis of over 2,000 children with complex malformations of cortical development identified five independent (four homozygous and one compound heterozygous) deleterious mutations in KATNB1, encoding the regulatory subunit of the microtubule-severing enzyme Katanin. Mitotic spindle formation is defective in patient-derived fibroblasts, a consequence of disrupted interactions of mutant KATNB1 with KATNA1, the catalytic subunit of Katanin, and other microtubule-associated proteins. Loss of KATNB1 orthologs in zebrafish (katnb1) and flies (kat80) results in microcephaly, recapitulating the human phenotype. In the developing Drosophila optic lobe, kat80 loss specifically affects the asymmetrically dividing neuroblasts, which display supernumerary centrosomes and spindle abnormalities during mitosis, leading to cell cycle progression delays and reduced cell numbers. Furthermore, kat80 depletion results in dendritic arborization defects in sensory and motor neurons, affecting neural architecture. Taken together, we provide insight into the mechanisms by which KATNB1 mutations cause human cerebral cortical malformations, demonstrating its fundamental role during brain development

Dealing with the gray zones in the management of gastric cancer: The consensus statement of the Istanbul Group

The geographical location and differences in tumor biology significantly change the management of gastric cancer. The prevalence of gastric cancer ranks fifth and sixth among men and women, respectively, in Turkey. The international guidelines from the Eastern and Western countries fail to manage a considerable amount of inconclusive issues in the management of gastric cancer. The uncertainties lead to significant heterogeneities in clinical practice, lack of homogeneous data collection, and subsequently, diverse outcomes