Patterns of multiple primaries in fortyfour cancer patients: a single-center clinical experience

Introduction. Multiple primaries are defined as the existence of more than one synchronous or metachronous cancer type in the same individual. Due to a longer follow-up time after a primary cancer diagnosis, the likelihood of detection of a second primary is also increased. We report on patterns of multiple primaries in a cohort of cancer patients from a single institution.  Material and methods. We identified 44 patients with multiple primaries that were diagnosed, treated, and followed up between March 2011 and January 2022 from our prospectively maintained database at the Hatay Education and Research Hospital Cancer Unit.  Results. The median follow-up time was 60 months (range; 3–103). The median time between the diagnosis of the first primary and the second primary was 29 months (range; 0–94). The median OS was 76 months (95% Cl 26.6–125.4) from the first diagnosis and 27 months (95% Cl 0.65–53.4) from the diagnosis of the second primary for the entire cohort. The first diagnosed tumor was localized in the gastrointestinal system in 43.2% of patients and 65.9% of all tumors were adenocarcinoma. The first diagnosed cancer was at an early stage (Stages I and II) in 63.6% of patients. At the staging evaluation of the second primary, 54.5% of patients were found to be in the early stage (Stages I and II) and 45.5% were found to be in the late stage (Stages III and IV).  Conclusions. Our study is important as this is the largest cohort study about practical implications of managing multiple primaries. The risk of second and further primaries should be kept in mind in the active follow-up Introduction and surveillance of cancer patients

A comparison of chevron and lindgren-turan osteotomy techniques in hallux valgus surgery: A prospective randomized controlled study

Objective: The aim of this prospective randomized controlled single-blind study was to compare the results of Chevron and Lindgren-Turan osteotomy techniques for treatment of moderate hallux valgus. Methods: A total of 66 female patients (34 in Chevron group, 32 Lindgren-Turan group) were recruited in this study and followed up for an average of 26.08 months. Operative procedures were performed by 2 surgeons, and patients were evaluated by an another researcher who was blinded to the surgical technique. The groups were compared for their radiological and clinical results. Results: Both techniques was clinically and radiologically effective (p0.05). Compared to the Chevron group, the Lindgren-Turan group was found to have shorter surgical duration (p<0.05) and significantly more shortening at the first metatarsal (p<0.05). Conclusion: In moderate hallux valgus deformity, both the Chevron and Lindgren-Turan osteotomy techniques are clinically and radiologically safe, effective, and reliable alternatives. No superiority was detected in either technique. Although shortening at the first metatarsal in the Lindgren-Turan group was radiologically significant, the results were clinically tolerable

Mesenchymal hamartoma of the liver

Mezenkimal hamartom, karaciğerin nadir görülen benign lezyonlarından biridir. Sıklıkla yaşamın ilk iki yılında, büyük abdominal kitle olarak ortaya çıkar. Daha çok sağ lobda görülen bu lezyonlar, gelişimsel bir anomali ya da reaktif bir değişiklik olarak kabul edilir. Karın sağ tarafında kitle yakınması ile getirilen, 14 aylık kız çocuk sağ adrenal glandda kitle ön tanısı ile operasyona alındı ve operasyon sırasında karaciğer sağ lobda 16 cm. çaplarında lezyon görüldü. Lezyondan alınan biyopsi materyalinin histopatolojik incelemesinde, miksomatöz stroma içinde yer alan duktus yapıları ve hepatosit adalarından oluşan iyi sınırlı tümöral gelişim izlendi. İmmunohistokimyasal boyamalarda, bu duktus yapılarının keratin ve vimentin ile pozitif boyandığı saptandı. Lezyon mezenkimal hamartom olarak değerlendirildi. Olgu nadir görülmesi nedeniyle sunuldu.Mesenchymal hamartoma is a rare benign lesion of liver. The most common presentation is big abdominal mass in the first 2 years of life. Mostly these lesions are seen in the right lob. Hamartoma is thought to be a developmental abnormality or reactive change. Fourteen months old female child was referred to our hospital and she underwent surgical treatment for the diagnosis of right adrenal gland mass. At surgery, the mass was 16 cm. in diameter in the right lobe of liver. Histhopathological examinations of the tissue revealed a lesion with a well defined borders. The tumor was consist of some islands of hepatocytes and ductal structures which were embedded in myxomatous stroma. Immunohistochemical stains showed positively for cytokeratin and vimentin in the ductal structures. In the light of these features the diagnosis was mesenchymal hamartoma. Because of its rarity, the case was presente

Effects of second generation tetracyclines on penicillin-epilepsy-induced hippocampal neuronal loss and motor incoordination in rats

Epileptic seizures cause pathological changes such as sclerosis and pyramidal neuronal loss in the hippocampus. Experimentally, epilepsy can be induced by application of various chemicals directly to the cerebral cortex. In this study, epilepsy was induced in rats by intracortical application of 500 IU penicillin G, and the effect of minocycline and doxycycline on the resulting motor incoordination (rotarod) and hippocampal neuronal loss in CA1, CA2 and CA3 fields (optical fractionator method) were investigated. The rotarod performance was reduced in the epilepsy group to 285.1 ± 6.9 s (P &lt; 0.05 vs. sham-300 s). Minocycline and doxycycline increased this performance to 297.4 ± 1.0 s and 296.9 ± 1.2 s respectively. No significant difference was detected between minocycline and doxycycline. The present results also showed that the number of neurons (× 103) in the sham group was 150 ± 9. In the penicillin-epileptic rats, the number was decreased to 105 ± 7 (P &lt; 0.01). Minocycline, but not doxycycline (125 ± 8), significantly increased the number to 131 ± 3 (P &lt; 0.05). In conclusion, the second generation tetracycline minocycline decreased the loss of hippocampal neurons and motor incoordination in penicillin-epileptic rats. Minocycline could protect against a variety of neurological insults including epilepsy. © 2006 Elsevier Inc. All rights reserved

Beyond traditional therapies: clinical significance of complex molecular profiling in patients with advanced solid tumours—results from a Turkish multi-centre study

Objective: The objective of this multi-centre, real-world study was to examine the potential influence of comprehensive molecular profiling on the development of treatment decisions or adjustments for patients with advanced solid malignancies. We then evaluated the impact of these informed choices on patient treatment outcomes. Methods: The study encompassed 234 adult patients (mean age: 52.7 ± 14.3 years, 54.7% women) who were diagnosed with solid tumours at 21 different medical centres in Turkey. Remarkably, 67.9% of the patients exhibited metastasis at the time of diagnosis. We utilized an OncoDNA (Gosselies, Belgium) platform (OncoDEEP) integrating next-generation sequencing with additional tests to harvest complex molecular profiling data. The results were analyzed in relation with two specific outcomes: (i) the impact on therapeutic decisions, including formulation or modifications, and (ii) associated treatment response. Results: Out of the 228 patients with final molecular profiling results, 118 (50.4%) had their treatment modified, whilst the remaining 110 (47.0%) did not. The response rates were comparable, with 3.9 versus 3.4% for complete response, 13.6 versus 29.3% for partial response, 66.9 versus 51.7% for progressive disease and 15.5 versus 15.5% for stable disease for treatments informed and not informed by complex molecular profiling, respectively (P = 0.16). Conclusion: Our real-world findings highlight the significant impact of complex molecular profiling on the treatment decisions made by oncologists for a substantial portion of patients with advanced solid tumours. Regrettably, no significant advantage was detected in terms of treatment response or disease control rates. © The Author(s) 2024. Published by Oxford University Press. All rights reserved