14 research outputs found
Filling Empty Seats: How Status and Organizational Hierarchies Affect Exploration Versus Exploitation in Team Design
Introducing New Educational Game Principles: A Case For Education And Behavior Engineering
RELATIONS BETWEEN NURSERY SCHOOL ATTENDANCE AND TEACHERS' RATINGS OF SOME ASPECTS OF CHILDREN'S ADJUSTMENT IN KINDERGARTEN1
Platelet membrane abnormalities in myeloproliferative disorders: decrease in glycoproteins Ib and IIb/IIIa complex is associated with deficient receptor function
A SNP panel for early detection of artificial chimerism in HSCT patients using TaqMan technology
Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer\u27s disease
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer\u27s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p \u3c 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures (R = 0.48, p \u3c 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes (R = 0.48, p \u3c 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming