ERYTHROKINETICS IN ALUMINIUM-TREATED ANIMALS

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STUDY OF THE INFLUENCE OF MONTHLY CIRCADIAN BIOLOGICAL RHYTHMS ON THE TOTAL MORTALITY

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INFLUENCE OF ALUMINIUM ON T HE CONCENTRATION OF PHOSPHORUS AND ADENYL NUCLEOTIDES IN WHITE RAT ERYTHROCYTES

The experiment covered 126 white male rats divided into two groups: 70 poisoned rats (group one) and 56 control ones (group two). Animals from the first group were perorally introduced I per cent of water solution of AlCl3 in a dosis of 3 mg Al3+/kg body mass daily for 40 days. The concentrations of inorganic phosphorus and adenyl nucleotides such as AMP, ADP and ATP in rat erythrocytes were determined on the 5th, 10th, 15th, 20th, 30th, and 40th day of trial. An elevation of ATP concentration tending towards a shift to the left of ATP/ADP balance during the second half of the experiment was established. Inorganic phosphorus reduced significantly during the whole trial. These alterations testify to disturbed processes of erythrocytic energy Metabolism

STUDY OF T H E INFLUENCE OF MANGANESE UPON SULFHYDRIL GROUP CONTENT IN RAT ERYTHROCYTES

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BIOCHEMICAL PARAMETERS OF WORKERS EXPOSED TO MANGANESE

The study covered 34 workers from a manganese mine (group one) and 33 workers from a flux manufacture (group two). The following parameters were examined: total protein, protein fractions, immunoglobulins A, M, and G, total cholesterol, the enzyme activity of ASAT, ALAT, GLDH, LDH, and CE in the serum, as well as manganese in the blood by using the method of atomic absorption spectrophotometry. Blood manganese concentration was reliably elevated. There was reduction of total protein and albumin contents while alpha 2-globulins were enhanced for the second group only. The immunoglobulin A was increased which was more outlined for the group two whilst the total cholesterol increase was more manifested for the group one. All the enzymes were significantly activated. The necessity for dynamic follow-up of the parameters examined during the evaluation of the health risk and monitoring the health status of workers from manganese-dangerous projects was emphasized

EVALUATION OF SOME CLINICO-LABORATORY AND CYTOPHOTOMETRIC PARAMETERS AS EARLY DIAGNOSTIC TESTS FOR LEAD INTOXICATION

The clinical manifestation and extent of intoxication by lead aerosols in 51 workers from lead-dangerous manufactures has been follow ed-up. The values of erythrocytometric and laboratory parameters have been estimated. Significant aberrations in the mean erythrocyte diameter, mean erythrocyte thickness and mean erythrocyte spherical index as well as in the urinary delta-aminolevulinic acid excretion have been established during the preclinical stage of saturnism. Morphometric parameters along with delta-aminolevulinic acid possess the highest information value concerning lead intoxication followed by blood hemoglobin values. Both moderate reticulocytosis and erythrocytes with basophilic punctations are insufficiently indicative for the early etiologic diagnosis. Cytomorphometric abnormalities which become more outlined with advancing pathological alterations are of high specificity and validity as early diagnostic tests for lead intoxication

SHIFT-WORK DYNAMICS OF SOME PARAMETERS OF FATIGUE AND WORKING CAPACITY IN AIR-TRAFFIC CONTROLLERS

The purpose of the present work was to study the changes of some psychophysiological parameters in air-traffic controllers under the influence of the working process and occupational environment. Some 28 air-traffic controllers at a mean age of 34,9 years and mean length of service of 11,8 уears were examined. A dynamic following-up the changes of psychic working capacity according to the shift-work regimen - at the beginning and at the end of the morning, afternoon and night shifts was performed. Fatigue and neuro-emotional stress underwent a subjective evaluation. Objectively, the following parameters were examined: attention properties, speed and preciseness of the visual-motor reaction, movement coordination, static tremor, and rate of hand movements. The labour of the air-trafic controllers was characterized by a high intensity and was related with heavy resposibility and permanent stress situations as well. A significant subjective reduction of the working capacity along with an enhanced voluntary effort at the end of the working shifts was established. The subjective scores were lower during the night shift than those during the day shift. The changes of the attention parameters such as productivity, volume and rate of processed information during the night shift appeared to be particularly indicative when the objective examinations were concerned

MORPHOLOGICAL ALTERATIONS IN SPLEEN AND LYMPH NODES OF EXPERIMENTAL RATS TREATED WITH AICI3

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BIOLOGICAL PROPHYLAXIS OF OCCUPATIONAL EXPOSURE TO LEAD

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EXPERIMENTAL INVESTIGATION OF THE EFFECT OF PERORALLY APPLIED ALUMINIUM ON THE STRUCTURE AND FUNCTION OF SOME INTERNAL ORGANS. LUNG ALTERATIONS IN RATS

The authors examined the lung lesions caused by peroral aluminium application as a 0,1 % solution of AlСl3 in a dose of 3 mg Al3+/kg b. w. for 40 days in a total of 126 white male rats (70 experimental and 56 control). Visible structural alterations were established on the 15th day of the trial consisting in desquamation of bronchial epithelium, enhanced pmounts of acid glucosaminoglycans in the cell cytoplasm and irregular disposition of cells. Later on, the activity of SDH, alkaline phosphatase, and ATP-ase decreased but acid phosphatase activity increased. Connective-tissue fibres grew up in the wall of some bronchi. These morphological findings suggest that although perorally accepted, AlСl3 induced structural lesions in the lungs as well as metabolic disturbances in the bronchial mucosa which depended on the duration of treatment