Comparative effectiveness of intensity modulated radiation therapy to 3-dimensional conformal radiation in locally advanced lung cancer: pathological and clinical outcomes.

OBJECTIVE: Intensity-modulated radiotherapy (IMRT) has better normal-tissue sparing compared with 3-dimensional conformal radiation (3DCRT). We sought to assess the impact of radiation technique on pathological and clinical outcomes in locally advanced non-small cell lung cancer (LANSCLC) treated with a trimodality strategy. METHODS: Retrospective review of LANSCLC patients treated from August 2012 to August 2018 at Sheba Medical Center, Israel. The trimodality strategy consisted of concomitant chemoradiation to 60 Gray (Gy) followed by completion surgery. The planning target volume (PTV) was defined by co-registered PET/CT. Here we compare the pathological regression, surgical margin status, local control rates (LC), disease free (DFS) and overall survival (OS) between 3DCRT and IMRT. RESULTS: Our cohort consisted of 74 patients with mean age 62.9 years, male in 51/74 (69%), adenocarcinoma in 46/74 (62.1%), stage 3 in 59/74 (79.7%) and chemotherapy in 72/74 (97.3%). Radiation mean dose: 59.2 Gy (SD ± 3.8). Radiation technique : 3DCRT in 51/74 (68.9%), IMRT in 23/74 (31%). Other variables were similar between groups.Major pathological response (including pathological complete response or less than 10% residual tumor cells) was similar: 32/51 (62.7%) in 3DCRT and 15/23 (65.2%) in IMRT, p=0.83. Pathological complete response (pCR) rates were similar: 17/51 (33.3%) in 3DCRT and 8/23 (34.8%) in IMRT, p=0.9. Surgical margins were negative in 46/51 (90.1%) in 3DCRT vs. 17/19 (89.4%) in IMRT (p=1.0).The 2-year LC rates were 81.6% (95% CI 69-89.4%); DFS 58.3% (95% CI 45.5-69%) and 3-year OS 70% (95% CI57-80%). Comparing radiation techniques, there were no significant differences in LC (p=0.94), DFS (p=0.33) and OS (p=0.72). CONCLUSION: When used to treat LANSCLC in the neoadjuvant setting, both IMRT and 3DCRT produce comparable pathological and clinical outcomes. ADVANCES IN KNOWLEDGE: This study validates the real-world effectiveness of IMRT compared to 3DCRT

Case report: A novel model for educating radiation therapists in small countries: Case study of the “Train the Trainer” initiative in Israel

Introduction: Israel, as a small country faces many challenges to deliver quality RTT education. As technologies evolve, the need for RTT education becomes acute. This resulted in the Ministry of Health, IAEA and ESTRO running the train the trainers (TTT) program in a unique format. Method: An expanded TTT program was run in Israel. This resulted in the establishment of the National Center for Radiotherapy Education (NCRE). Key elements of the NCRE include national leadership, high-tech teaching environment, simulation based teaching methodologies, and evidence based education.Educational outcomes of the RTT course run in the NCRE were measured and statistically analysed. Results: The measurement of educational outcome was highly significant (p < 0.00001). The feedback from the course was very positive, with a high aggregate data mean score for all questions pertaining to the effect the course has on work, and efficient use of time. Discussion: The success of the RTT course of the NCRE is evident from the results. The impact of the TTT program went beyond RTT education, as the NRCE is a national radiotherapy education resource, utilized by all radiotherapy professionals. Conclusion: More knowledgeable RTTs may be able to work in advanced roles, taking on tasks from other sectors in the department; this could improve the efficiency of patient care and improve the safety of radiotherapy delivery. Keywords: RTT education, Train the Trainers, Simulation based educatio