Improving customer satisfaction through the management of perceptions of waiting

Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1989.Includes bibliographical references (leaves 112-113).by Karen L. Katz and Blaire R. Martin.M.S

Anderson et al. Reply (to the Comment by Katz on Pioneer 10/11)

We conclude that Katz's proposal (anisotropic heat reflection off of the back of the spacecraft high-gain antennae, the heat coming from the RTGs) does not provide enough power and so can not explain the Pioneer anomaly.Comment: LaTex, 3 pages, Phys. Rev. Lett. (to be published

Accumulation of glial fibrillary acidic protein and histone H4 in brain storage bodies of Tibetan terriers with hereditary neuronal ceroid lipofuscinosis

The neuronal ceroid lipofuscinoses (NCLs) are inherited neurodegenerative diseases characterized by massive accumulation of autofluorescent storage bodies in neurons and other cells. A late-onset form of NCL occurs in Tibetan terrier dogs. Gel electrophoretic analyses of isolated storage body proteins from brains of affected dogs indicated that a protein of approximately 50 kDa was consistently prominent and a 16 kDa component was present in some brain storage body preparations. Mass spectral analysis identified the 50 kDa protein as glial fibrillary acidic protein (GFAP), isoform 2. GFAP identification was supported by immunoblot and immunohistochemical analyses. Histone H4 was the major protein in the 16 kDa component. Specific accumulation of GFAP and histone H4 in storage bodies has not been previously reported for any of the NCLs. Tibetan terrier NCL may be the canine correlate of one of the human adult-onset NCLs for which the genetic bases and storage body compositions have not yet been determined

Photometric and dynamic evolution of an isolated disc galaxy simulation

We present a detailed analysis of the evolution of a simulated isolated disc galaxy. The simulation includes stars, gas, star formation and simple chemical yields. Stellar particles are split in two populations: the old one is present at the beginning of the simulation and is calibrated according to various ages and metallicities; the new population borns in the course of the simulation and inherits the metallicity of the gas particles. The results have been calibrated in four wavebands with the spectro-photometric evolutionary model GISSEL2000 (Bruzual & Charlot 1993). Dust extinction has also been taken into account. A rest-frame morphological and bidimensional photometric analysis has been performed on simulated images, with the same tools as for observations. The effects of the stellar bar formation and the linked star formation episode on the global properties of the galaxy (mass and luminosity distribution, colours, isophotal radii) have been analysed. In particular, we have disentangled the effects of stellar evolution from dynamic evolution to explain the cause of the isophotal radii variations. We show that the dynamic properties (e.g. mass) of the area enclosed by any isophotal radius depends on the waveband and on the level of star formation activity. It is also shown that the bar isophotes remain thinner than mass isodensities a long time (> 0.7 Gyr) after the maximum of star formation rate. We show that bar ellipticity is very wavelength dependent as suggested by real observations. Effects of dust extinction on photometric and morphological measurements are systematically quantified.Comment: 14 pages, 16 figures (13 in eps, 3 in jpg format). Accepted for publication in A&

A model of fasciculation and sorting in mixed populations of axons

We extend a recently proposed model (Chaudhuri et al., EPL 87, 20003 (2009)) aiming to describe the formation of fascicles of axons during neural development. The growing axons are represented as paths of interacting directed random walkers in two spatial dimensions. To mimic turnover of axons, whole paths are removed and new walkers are injected with specified rates. In the simplest version of the model, we use strongly adhesive short-range inter-axon interactions that are identical for all pairs of axons. We generalize the model to adhesive interactions of finite strengths and to multiple types of axons with type-specific interactions. The dynamic steady state is characterized by the position-dependent distribution of fascicle sizes. With distance in the direction of axon growth, the mean fascicle size and emergent time scales grow monotonically, while the degree of sorting of fascicles by axon type has a maximum at a finite distance. To understand the emergence of slow time scales, we develop an analytical framework to analyze the interaction between neighboring fascicles.Comment: 19 pages, 13 figures; version accepted for publication in Phys Rev

The Highest-redshift Balmer Breaks as a Test of ΛCDM

Recent studies have reported tension between the presence of luminous, high-redshift galaxies and the halo mass functions predicted by standard cosmology. Here, an improved test is proposed using the presence of high-redshift Balmer breaks to probe the formation of early 104–105 M ⊙ baryonic minihalos. Unlike previous tests, this does not depend upon the mass-to-light ratio and has only a slight dependence upon the metallicity, stellar initial mass function, and star formation history, which are all weakly constrained at high redshift. We show that the strongest Balmer breaks allowed at z = 9 using the simplest ΛCDM cosmological model would allow a D 4000 as high as 1.26 under idealized circumstances and D 4000 ≤ 1.14 including realistic feedback models. Since current photometric template fitting to JWST sources infers the existence of stronger Balmer breaks out to z ≳ 11, upcoming spectroscopic follow-up will either demonstrate those templates are invalid at high redshift or imply new physics beyond “vanilla” ΛCDM

Towards convergence of turbulent dynamo amplification in cosmological simulations of galaxies

Our understanding of the process through which magnetic fields reached their observed strengths in present-day galaxies remains incomplete. One of the advocated solutions is a turbulent dynamo mechanism that rapidly amplifies weak magnetic field seeds to the order of ${\sim}\mu$G. However, simulating the turbulent dynamo is a very challenging computational task due to the demanding span of spatial scales and the complexity of the required numerical methods. In particular, turbulent velocity and magnetic fields are extremely sensitive to the spatial discretisation of simulated domains. To explore how refinement schemes affect galactic turbulence and amplification of magnetic fields in cosmological simulations, we compare two refinement strategies. A traditional quasi-Lagrangian adaptive mesh refinement approach focusing spatial resolution on dense regions, and a new refinement method that resolves the entire galaxy with a high resolution quasi-uniform grid. Our new refinement strategy yields much faster magnetic energy amplification than the quasi-Lagrangian method, which is also significantly greater than the adiabatic compressional estimate indicating that the extra amplification is produced through stretching of magnetic field lines. Furthermore, with our new refinement the magnetic energy growth factor scales with resolution following \propto \Dres^{-1/2}, in much better agreement with small-scale turbulent box simulations. Finally, we find evidence suggesting most magnetic amplification in our simulated galaxies occurs in the warm phase of their interstellar medium, which has a better developed turbulent field with our new refinement strategy.Comment: Replaced to match version accepted for publication in MNRAS. 20 pages, 17 figures and 2 appendice

Characterization of degeneration in the retina, brain and spinal cord of the Cln1 knockout mouse

Abstract only availableThe neuronal-ceroid lipofuscinoses (NCLs; often referred to as Battens Disease) are a group of hereditary disorders of childhood. Symptoms of NCLs are characterized by neurodegeneration with progressive neural cell death in the retina and central nervous system (CNS). The infantile form of NCL results from a deficiency in the protein, palmitoyl protein thioesterase-1 (PPT-1). PPT-1, encoded by the Cln1 gene, removes long chain fatty acids from modified cysteine residues in proteins. Mutations in the Cln1 gene are associated with an accumulation of autofluorescent lysosomal lipopigments in various tissues such as the retina and CNS. In the current study, we use a transgenic mouse model in which the gene for Cln1 has been mutated, i.e., 'knocked out'. Our goal is to perform histological experiments to assess the functional progression of neurodegenerative changes in the retina, brain and spinal cord as the subject ages. The retina, brain and spinal cord of the mice at different ages were fixed and embedded in plastic resin and/or paraffin. Thick sections (1 mm or 10 mm, respectively) were stained with toluidine blue or propidium iodide to detect neuronal loss and/or apoptosis as a result of the PPT-1 deficiency. Fluorescent images of the stained sections were obtained to document changes in tissue structure and the extent of degeneration. These studies provide information that will aid future studies in which stem cell transplants will be made into the Cln1 knockout mouse model. Ultimately, this approach will determine whether combined gene and stem cell therapies can be applied to patients with Battens Disease.Molecular Biology Progra