What's age got to do with it? Supreme Court appointees and the long run location of the Supreme Court median justice

For approximately the past forty years, Republican Presidents have appointed younger Justices than have Democratic Presidents. Depending on how one does the accounting, the average age difference will vary, but will not go away. This Article posits that Republicans appointing younger justices than Democrats may have caused a rightward shift in the Supreme Court. We use computer simulations to show that if the trend continues the rightward shift will likely increase. We also produce some very rough estimates of the size of the ideological shift, contingent on the size of the age differential. In addition, we show that the Senate’s role in confirming nominated Justices has a significant moderating effect on the shift. Last, we consider the interaction between our results and the oft-proposed eighteen year staggered terms for Supreme Court Justices. We show that such an institutional change would almost completely wipe out the ideological effect of one Party appointing younger Justices

What’s age to do with it? Supreme Court appointees and the long run location of the Supreme Court median justice

[No abstract

Sommerfeld Enhancements for Thermal Relic Dark Matter

The annihilation cross section of thermal relic dark matter determines both its relic density and indirect detection signals. We determine how large indirect signals may be in scenarios with Sommerfeld-enhanced annihilation, subject to the constraint that the dark matter has the correct relic density. This work refines our previous analysis through detailed treatments of resonant Sommerfeld enhancement and the effect of Sommerfeld enhancement on freeze out. Sommerfeld enhancements raise many interesting issues in the freeze out calculation, and we find that the cutoff of resonant enhancement, the equilibration of force carriers, the temperature of kinetic decoupling, and the efficiency of self-interactions for preserving thermal velocity distributions all play a role. These effects may have striking consequences; for example, for resonantly-enhanced Sommerfeld annihilation, dark matter freezes out but may then chemically recouple, implying highly suppressed indirect signals, in contrast to naive expectations. In the minimal scenario with standard astrophysical assumptions, and tuning all parameters to maximize the signal, we find that, for force-carrier mass m_phi = 250 MeV and dark matter masses m_X = 0.1, 0.3, and 1 TeV, the maximal Sommerfeld enhancement factors are S_eff = 7, 30, and 90, respectively. Such boosts are too small to explain both the PAMELA and Fermi excesses. Non-minimal models may require smaller boosts, but the bounds on S_eff could also be more stringent, and dedicated freeze out analyses are required. For concreteness, we focus on 4 mu final states, but we also discuss 4 e and other modes, deviations from standard astrophysical assumptions and non-minimal particle physics models, and we outline the steps required to determine if such considerations may lead to a self-consistent explanation of the PAMELA or Fermi excesses.Comment: 31 pages, published versio

Is there an excess of black holes around 20M⊙20 M_{\odot}? Optimising the complexity of population models with the use of reversible jump MCMC

Some analyses of the third gravitational wave catalogue released by the LIGO-Virgo-KAGRA collaboration (LVK) suggest an excess of black holes around $15-20 M_{\odot}$. In order to investigate this feature, we introduce two flexible population models, a semi-parametric one and a non-parametric one. Both make use of reversible jump Markov chain Monte-Carlo to optimise their complexity. We also illustrate how the latter can be used to efficiently perform model selection. Our parametric model broadly agrees with the fiducial analysis of the LVK, but finds a peak of events at slightly larger masses. Our non-parametric model shows this same displacement. Moreover, it also suggests the existence of an excess of black holes around $20 M_{\odot}$. We assess the robustness of this prediction by performing mock injections and running hierarchical analyses on those. We find that such a feature might be due to statistical fluctuations, given the small number of events observed so far, with a $5\%$ probability. We estimate that with a few hundreds of observations, as expected for O4, our non-parametric model will, be able to robustly determine the presence of this excess. It will then allow for an efficient agnostic inference of the properties of black holes.Comment: correct typo in equation

Effects of clonidine and some α-adrenergic antagonists alone and in combination on schedule-controlled behavior in pigeons and mice

Schedule-controlled responding was maintained under multiple fixed-interval, fixed-ratio schedules in pigeons and single fixed-ratio schedules in mice. In pigeons, clonidine, an α 2 -receptor agonist, produced dose-related decreases in responding under both fixed-interval and fixedratio schedules; fixed-interval responding was decreased at a lower dose than fixed-ratio responding. Low to intermediate doses of yohimbine, an α 2 -receptor antagonist, increased responding under the fixed-interval schedule without appreciably affecting responding under the fixed-ratio schedule; higher doses decreased responding under both schedules. In mice, both clonidine and yohimbine produced dose-related decreases in responding under fixed-ratio schedules. Decreases in response rates produced by clonidine were antagonized by low to intermediate doses of yohimbine. Decreases in response rates under fixed-ratio schedules produced by yohimbine were antagonized only slightly, if at all, by clonidine. Under the fixed-interval schedule, clonidine potentiated the response-rate increasing effects of intermediate doses of yohimbine and slightly antagonized the rate-decreasing effects. Although some effects of clonidine were antagonized by yohimbine, at no dose combination did performances completely resemble control performances. Prazosin, an α 1 -receptor antagonist, was ineffective both when administered alone and as an antagonist of the effects of clonidine. The behavioral effects of clonidine appeared to be mediated by α 2 rather than α 1 receptors. Additionally, yohimbine appears to have significant behavioral effects other than α 2 -antagonist actions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46431/1/213_2004_Article_BF00427419.pd

Insulin mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by Rosiglitazone

Background: Obesity associated hypertension is likely to be due to multiple mechanisms. Identification of the renin-angiotensin system (RAS) within adipose tissue does, however, suggest a potential causal role for it in obesity-associated hypertension. Obese patients are often hyperinsulinaemic, but mechanisms underlying insulin upregulation of the RAS in adipose tissue are unclear. TNFα, an inducer of angiotensinogen in hepatocytes, is elevated in hyperinsulinaemic, obese individuals, and may provide a link in mediating insulin upregulation of the RAS in adipose tissue. Further, thiazolidinediones lower blood pressure in vivo and downregulation of the RAS in adipose tissue may contribute to this effect. We therefore examined the effect of rosiglitazone (RSG), on the insulin mediated upregulation of the RAS. Methods and Results: Sera were obtained from the arterial circulation and from venous blood draining subcutaneous abdominal adipose tissue. Isolated human abdominal subcutaneous adipocytes (n=12) were treated with insulin (1-1000nM) and insulin in combination with RSG (10nM), and RSG (10nM) alone to determine angiotensinogen expression, angiotensin II, bradykinin and TNFα secretion. Subcutaneous adipocytes were also treated with TNFα (10-100ng/mL) to examine the direct effect on angiotensinogen expression and angiotensin II secretion. The findings showed that the arterio-venous difference in angiotensin II levels was significant (↑23%; p<0.001). Insulin increased TNFα secretion in a concentration-dependent manner (p<0.01) whilst RSG (10nM) significantly reduced the insulin mediated rise in TNFα (p<0.001), as well as AGT and angiotensin II. TNFα also increased angiotensinogen and angiotensin II in isolated adipocytes. Conclusions: Our in vivo data suggest that human subcutaneous adipose tissue is a significant source of angiotensin II. This study also demonstrates a potential TNFα mediated mechanism through which insulin may stimulate the RAS and may contribute to explain obesity associated hypertension. RSG downregulates the RAS in subcutaneous adipose tissue and this effect may contribute to the long-term effect of RSG on blood pressure