Effects of Sultopride and Sulpiride on Serum Prolactin Level in Schizophrenia.

Sultopride or sulpiride was administered to 26 schizophrenic patients. In the male patients, there was a significant correlation between serum concentrations of sultopride and sulpiride and prolactin response. In the female patients, there was no significant correlation between them. In sultopride treatment, prolaction response was suggested to be predictive of a good therapeutic response

WATER INTOXICATION IN A DRUG-FREE SCHIZOPHRENIC PATIENT

A 27-year-old woman with schizophrenia disorder developed water intoxica- tion due to primary polydipsia in drug-free state. Manner of vasopressin secretion was investigated with water loading and hypertonic saline infusion. The sensitivity of vasopres- sin secretion response to changing osmolality was low in this patient, which might be involved in the occurrence of water intoxication, linked to Type Ⅳ SIADH