Nasolabial cyst in a patient with cleft lip and recurrent dacryocystitis

Nasolabial cysts are uncommon non-odontogenic cysts that appear mainly in females of the fourth and fifth decade of life. This paper presents a 45-year-old female with a nasolabial cyst, who also had ipsilateral cleft lip and a history of recurrent dacryocystitis. © 2019 Asian AOMS(+) ASOMP(+) JSOP(+) JSOMS(+) JSOM(+) and JAM

In vivo antineoplastic effects of the NSAID sulindac in an oral carcinogenesis model

The antineoplastic properties of the NSAID sulindac have long been studied. The purpose of this study was to explore sulindac's in vivo effects on oral squamous cell carcinoma (SCC) oncogenesis using the hamster cheek pouch oral carcinogenesis model (HOCM). Thirty Syrian golden hamsters were divided into three experimental and two control groups (n = 6 each). The animals' right buccal pouches were treated with carcinogen for 9 weeks in one experimental and one control group and for 14 weeks in all other three groups. The animals of two experimental groups received sulindac from the 1st week and those of the third experimental group from the 10th week. After the end of carcinogenesis, treated buccal pouches were removed and examined. In animals treated with carcinogen for 14 weeks, development of oral SCC and tumor volume were significantly lower in animals that received sulindac from the first week of the experiment. Oral SCC developing in animals that received sulindac were more frequently well differentiated compared with the control group. In animals treated with carcinogen for 9 weeks, the animals that received sulindac developed lower grade of epithelial dysplasia. Proliferation index Ki-67 and positivity for the antiapoptotic molecule survivin were lower in the animals that received sulindac. Treatment with sulindac appears to delays the progression of oral premalignant lesions to oral SCC in the HOCM, also resulting in smaller and better differentiated tumors. These in vivo antineoplastic effects may be related to sulindac's ability to decrease cell proliferation and to prevent survivin expression. ©2015 AACR

Large erupted complex odontoma with dentigerous cyst

Odontomas, the most common benign odontogenic tumors, are usually asymptomatic. Eruption of these lesions in the oral cavity can rarely be occurred, and accompanied by a wide range of clinical signs and symptoms. Among the developmental odontogenic cysts, the dentigerous cyst is the most common type. However, a dentigerous cyst associated with an erupted odontoma is an extremely rare finding. A case of a large erupted complex odontoma is presented in a 23-year-old man. Intraoral examination revealed an irregular, solid yellowish tumor-like mass measuring about 2 cm with calcified surface. Radiographic examination showed a dense well-defined radiopaque lesion located distal of the mandibular left second molar and above the crown of the impacted third molar. The mandibular molars and the attached hard and soft tissues were surgically removed. The histopathological diagnosis of complex odontoma combined with the eruption of the lesion in the oral cavity set the diagnosis of erupted complex odontoma. Histopathological examination revealed that the attached soft tissue associated with odontoma was an inflamed dentigerous cyst. In conclusion, the exposure within the oral microflora of a large in size erupted odontoma may contribute as predisposing factor for a local inflammation that needs surgical intervention. © 2017 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAM