Investigating the gaze control ability of VALORANT players using a Python based tool

The current study investigated the gaze movements of FPS gamers in actual game environments. We developed a low-cost analysis tool using Python to identify gaze movements in real-world gaming environments. In Experiment 1, 11 middle-skilled and ten high-skilled FPS gamers performed a task under the experimental condition. Gaze position, reaction time, and accuracy were calculated during the task. Reaction time exhibited a significant positive correlation with task accuracy, suggesting that speed and accuracy were associated with higher game performance. The middle-skilled gamers had a significantly wider horizontal gaze distribution than the high-skilled gamers, and gaze distribution and reaction time showed a negative correlation. These results suggested that high-skilled players utilize peripheral vision during gameplay. In Experiment 2, 15 middle-skilled and 12 high-skilled FPS gamers performed an actual FPS game match. The gaze distribution, kill/death/assist ratio (KDA), and percentage of gaze on game information were calculated. In experiment 2, gaze locations in less important areas were positively correlated with KDA. Thus, performance was determined by the important areas where the gaze was focused rather than by the coordination of gaze position alone. Therefore, a broader range of environments is necessary to comprehend the superior performance of FPS gamers.Comment: 8 Pages, 8 figures, submitted in IEEE Transactions on Game

Pregabalin- and azithromycin-induced rhabdomyolysis with purpura: An unrecognized interaction: A case report

AbstractIntroductionRhabdomyolysis associated with the use of pregabalin or azithromycin has been demonstrated to be a rare but potentially life-threatening adverse event. Here, we report an extremely rare case of rhabdomyolysis with purpura in a patient who had used pregabalin and azithromycin.Presentation of caseWe present the case of a 75-year-old woman with a history of fibromyalgia who was admitted with mild limb weakness and lower abdominal purpura. She was prescribed pregabalin (75mg, twice daily) for almost 3 months to treat chronic back pain. Her medical history revealed that 3days before admission, she began experiencing acute bronchitis and was treated with a single dose of azithromycin (500mg). She had developed rapid onset severe myalgia, mild whole body edema, muscle weakness leading to gait instability, abdominal purpura and tender purpura on the lower extremities. Laboratory values included a white blood cell count of 25,400/mL and a creatinine phosphokinase (CPK) concentration of 1250 IU/L. Based on these findings and the patient’s clinical history, a diagnosis of pregabalin- and azithromycin-induced rhabdomyolysis was made.DiscussionThe long-term use of pregabalin and the initiation azithromycin therapy followed by a rapid onset of rhabdomyolysis is indicative of a drug interaction between pregabalin and azithromycin.ConclusionWe report an extremely rare case of rhabdomyolysis with purpura caused by a drug interaction between pregabalin and azithromycin. However, the mechanisms of the interactions between azithromycin on the pregabalin are still unknown

ヒト単球のインターロイキン6遺伝子発現に対するインターロイキン1および腫瘍壊死因子(TNF-α)の役割

取得学位 : 博士（医学）, 学位授与番号 : 医博乙第1227号,学位授与年月日：平成5年5月19日,学位授与年：199

Role of interleukin 6 for differential responsiveness of naive and memory CD4+ T cells in CD2-mediated activation

金沢大学大学院医学系研究科血管病態制御学The present study was undertaken to elucidate different requirements for CD2-mediated activation of naive (CD45RO-) and memory (CD45RO+) CD4+ T cells. A mitogenic combination of anti-CD2 (anti-T112 and anti-T113) mAbs could effectively induce the proliferation of memory CD4+ T cells even in the absence of monocytes. In marked contrast, naive CD4+ T cells did not disclose any proliferative responses to antiCD2 mAbs, when monocytes were absent in culture. This differential responsiveness of naive and memory CD4+ T cells appeared to be related largely to a difference in IL-6 - producing ability between both populations. IL-6 among monocyte-derived cytokines could correct unresponsiveness of naive CD4+ T cells to anti-CD2 stimulation. Unlike naive CD4+ T cells, memory CD4+ T cells produced IL-6 by themselves, with its mRNA being expressed on anti-CD2 stimulation. Anti-IL-6R mAb significantly inhibited proliferation of memory CD4+ T cells seen in the anti-CD2-stimulated cultures without monocytes, indicating the involvement of their own production of IL-6 in CD2-mediated activation. The results suggest an essential role of IL-6 for triggering of CD4+ T cells via the CD2 molecule

Role of interleukin 6 for differential responsiveness of naive and memory CD4+ T cells in CD2-mediated activation

The present study was undertaken to elucidate different requirements for CD2-mediated activation of naive (CD45RO-) and memory (CD45RO+) CD4+ T cells. A mitogenic combination of anti-CD2 (anti-T112 and anti-T113) mAbs could effectively induce the proliferation of memory CD4+ T cells even in the absence of monocytes. In marked contrast, naive CD4+ T cells did not disclose any proliferative responses to antiCD2 mAbs, when monocytes were absent in culture. This differential responsiveness of naive and memory CD4+ T cells appeared to be related largely to a difference in IL-6 - producing ability between both populations. IL-6 among monocyte-derived cytokines could correct unresponsiveness of naive CD4+ T cells to anti-CD2 stimulation. Unlike naive CD4+ T cells, memory CD4+ T cells produced IL-6 by themselves, with its mRNA being expressed on anti-CD2 stimulation. Anti-IL-6R mAb significantly inhibited proliferation of memory CD4+ T cells seen in the anti-CD2-stimulated cultures without monocytes, indicating the involvement of their own production of IL-6 in CD2-mediated activation. The results suggest an essential role of IL-6 for triggering of CD4+ T cells via the CD2 molecule

Primary adenocarcinoma of the stomach in von Recklinghausen's disease with high serum levels of multiple tumor markers: a case report

<p>Abstract</p> <p>Introduction</p> <p>Gastric tumors in patients affected by neurofibromatosis type 1 are usually carcinoids or stromal tumors, and rarely adenocarcinomas.</p> <p>Case presentation</p> <p>We report a case of an adenocarcinoma of the stomach in a 53-year-old Japanese man with neurofibromatosis type 1. An abdominal computed tomography scan and ultrasonography showed tumors in his liver. Gastric fibroscopy revealed a Borrmann type III tumor on his cardia that had spread to his esophagus and was highly suspicious for malignancy. Multiple biopsies showed an adenocarcinoma of the stomach, which was evaluated as gastric cancer, stage IV. Chemotherapy with TS-1 was performed. Our patient died four weeks after initial admission. Histological examination of a liver needle biopsy showed metastatic adenocarcinoma in his liver.</p> <p>Conclusion</p> <p>To the best of our knowledge, high serum levels of α-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 72-4, resulting from gastric adenocarcinoma, have not been reported previously in a patient with neurofibromatosis type 1. We report this rare case along with a review of the literature.</p

Cytological localization of highly repeated DNA sequences, the FokI sequence family and BamHI sequence families, in Vica faba chromosomes

Cytological localization of one of the highly repeated DNA sequences of Vicia faba, the FokI repeat sequence family, was determined by in situ hybridization. This sequence family was described in our previous paper (Kato et al. 1984) as tandem arrays of 59bp unit sequences. The distribution pattern of silver grains showed that the FokI family sequences are exclusively localized in certain median regions in the long arms of all five pairs of the subtelocentric (S) chromosomes, but are not found in any portions in the metacentric (M) chromosomes. These median regions in the S long arms correspond closely to the positions of C-band heterochromatin revealed by preferential Giemsa staining. Since M chromosomes also possess C-bands, the absence of the FokI repeat sequences in the M chromosomes indicates that V. faba C-band heterochromatin consists of at least two different DNA sequences. V. faba chromosomes also contain other repetitive sequences, which have been characterized as the 250, 850, 900, 990, 1150, 1500 and 1750 by BamHI sequence families (Kato et al. 1985). In situ hybridization with nicktranslated 250 and 1500bp BamHI family sequences indicated that these repeated sequences are generally spread all over the chromosome