Chromatic vision and structural assessment in primary congenital glaucoma

Objetivo: Avaliar visão de cores, aferir espessura da camada de fibras nervosas (CFN) em crianças com glaucoma congênito primário (GCP) e correlacionar a espessura da CFN com a performance no teste de visão de cores. Métodos: Neste estudo transversal, 21 olhos de 13 crianças com GCP foram avaliados com teste de visão de cores de Farnsworth D-15 (FW D-15) e medida da espessura da CFN com tomografia de coerência óptica de domínio espectral (SD-OCT). Parâmetros como idade, acuidade visual, escavação do disco óptico e equivalente esférico foram correlacionados com os dados de visão de cores. Baseado na performance do teste de visão de cores, foram comparados os dados de espessura global e dos setores da CFN de disco óptico (cpCFN) e de mácula (mCFN). Resultados: Média da idade foi 8,33 (5-10) anos, média da relação escavação-disco 0,65 (0,2-0,9), mediana do equivalente esférico -3,79 D (0 a -17) e mediana da acuidade visual em decimal de Snellen 0,54 (0,10-1,0). Quatro olhos (19%) apresentaram teste de visão de cores alterado com padrão de difuso de discromatopsia. Idade foi único parâmetro que influenciou o teste de visão de cores na análise estatística de forma significante. A espessura da porção nasal da cpCFN mostrou diferença estatística entre os grupos. Conclusão: Na amostra avaliada, 4 olhos apresentaram alteração de visão de cores. No grupo com alteração em visão de cores, a camada nasal cpCFN apresentou maior afinamento.Purpose: To test color vision and evaluate retinal fiber layer (RNFL) thickness in children with primary congenital glaucoma (PCG) and to correlate color vision performance to RNFL thickness. Methods: In this cross-sectional study, 21 eyes of 13 PCG children were evaluated by Farnsworth D-15 (FW D-15) test to test color vision and by spectral domain optical coherence tomography (SD-OCT) to measure the RNFL thickness. Age, visual acuity, cup-to-disc ratio and spheric equivalent data were included in the color vision test analysis. The global and sectional peripapillary RNFL (cpRNFL) and macular RNFL (mRNFL) thickness were evaluated and compared according to the color vision test performance. Results: Mean age was 8.33 (5-10) years, mean cup-to-disc ratio was 0.65 (0.2-0.9), median spherical equivalent -3.79 D (0 to -17) and median decimal Snellen visual acuity was 0.54 (0.10 to 1.0). Four eyes (19%) failed in color vision test with diffuse dyschromatopsia pattern. Age was the only parameter that was statistically significant in color vision test. SD-OCT cpRNFL nasal layer thickness showed statically difference between the groups. Conclusion: In the sample evaluated, four eyes showed abnormal color vision.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)88887.364424/2019-0

Comparison of anterior segment optical coherence tomography angiography and fluorescein angiography for iris vasculature analysis

The aim of this study is to perform imaging of irises of different colors using spectral domain anterior segment optical coherence tomography angiography (AS-OCTA) and iris fluorescein angiography (IFA) and compare their effectiveness in examining iris vasculature. This is a cross-sectional observational clinical study. Patients with no vascular iris alterations and different pigmentation levels were recruited. Participants were imaged using OCTA adapted with an anterior segment lens and IFA with a confocal scanning laser ophthalmoscope (cSLO) adapted with an anterior segment lens. AS-OCTA and IFA images were then compared. Two blinded readers classified iris pigmentation and compared the percentage of visible vessels between OCTA and IFA images. Twenty eyes of 10 patients with different degrees of iris pigmentation were imaged using AS-OCTA and IFA. Significantly more visible iris vessels were observed using OCTA than using FA (W = 5.22p < 0.001). Iris pigmentation was negatively correlated to the percentage of visible vessels in both imaging methods (OCTA, rho = - 0.73, p < 0.001IFA, rho = - 0.77, p < 0.001). Unlike FA, AS-OCTA could not detect leakage of dye, delay, or impregnation. Nystagmus and inadequate fixation along with motion artifacts resulted in lower quality images in AS-OCTA than in IFA. AS-OCTA is a new imaging modality which allows analysis of iris vasculature. In both AS-OCTA and IFA, iris pigmentation caused vasculature imaging blockage, but AS-OCTA provided more detailed iris vasculature images than IFA. Additional studies including different iris pathologies are needed to determine the most optimal scanning parameters in OCTA of the anterior segment.Univ Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, Sao Paulo, BrazilPontificia Univ Catolica Valparaiso, Fac Ciencias, Carrera Tecnol Med, Valparaiso, ChileCAPES CNPq, PEC PG, Programa Estudantes Convenio Posgrad, Sao Paulo, BrazilUniv Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL USAUniv Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, Sao Paulo, BrazilWeb of Scienc

Aqueous misdirection syndrome in persistent fetal vasculature (PFV)

We report a case of a 5-year-old girl with persistent fetal vasculature who presented with unilateral acute angle closure caused by aqueous misdirection syndrome that was apparently associated with regression of cycloplegia. Initial treatment with topical steroids, anti-glaucomatous drops, and atropine showed insufficient control of the intraocular pressure (IOP). Surgical treatment with lensectomy and vitrectomy resulted in satisfactory IOP control and no complications at the 6-month follow-up.Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, SP, BrazilWeb of Scienc

TWELVE-MONTH FOLLOW-UP OF DEXAMETHASONE IMPLANTS FOR MACULAR EDEMA FROM VARIOUS DISEASES IN VITRECTOMIZED AND NON-VITRECTOMIZED EYES: RESULTS FROM THE PAN AMERICAN COLLABORATIVE RETINA STUDY GROUP

Univ Fed Sao Paulo, Sao Paulo, BrazilUniv Fed Goias, Sao Paulo, BrazilJohns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21218 USAAsociados Macula Vitreo & Retina Costa Rica, San Jose, Costa RicaUniv Puerto Rico, San Juan, PR 00936 USAUniv Fed Sao Paulo, Sao Paulo, BrazilWeb of Scienc