Molecular and Genetic Determinants of Glioma Cell Invasion.

A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation. Recently updated classification of diffuse gliomas based on distinct genetic and epigenetic features has culminated in a multilayered diagnostic approach to combine histologic phenotypes and molecular genotypes in an integrated diagnosis. However, it is still a work in progress to decipher how the genetic aberrations contribute to the aggressive nature of gliomas including their highly invasive capacity. Here we depict a set of recent discoveries involving molecular genetic determinants of the infiltrating nature of glioma cells, especially focusing on genetic mutations in receptor tyrosine kinase pathways and metabolic reprogramming downstream of common cancer mutations. The specific biology of glioma cell invasion provides an opportunity to explore the genotype-phenotype correlation in cancer and develop novel glioma-specific therapeutic strategies for this devastating disease

The Discourse of Feminization: Effeminate Characters in Japanese Cinema (1945-1969)

早稲田大学博士(国際コミュニケーション学)早大学位記番号:新9408doctoral thesi

A Matter of Choice: The Discipline of Interdisciplinary Programs and Japanese Cinema Studies

departmental bulletin pape

Fast Exponentiation in Extension Field with Frobenius Mappings

This paper proposes an exponentiation method with Frobenius mappings. Our method is closely related to so-called interleaving exponentiation. Different from the interleaving exponentiation methods, our method can carry out several exponentiations using same base at the same time. The efficiency to use Frobenius mappings for an exponentiation in extension field is well introduced by Avanzi and Mihailescu. This exponentiation method is based on so-called simultaneous exponentiation and uses many Frobenius mappings. Their method more decreased the number of multiplications; however, the number of Frobenius mappings inversely increased. Compared to their method , the number of multiplications needed for the proposed method becomes about 20% larger; however, that of Frobenius mappings becomes small enough

Extension Field for Xate Pairing with Freeman Curve

Recently, pairing-based cryptographies such as ID-based cryptography and group signature have been studied. For fast pairing calculation, not only pairing algorithms but also arithmetic operations in extension field must be efficiently carried out. The authors show efficient arithmetic operations of extension field for Xate pairing especially with Freeman curve

Tungsten vs Selenium as a potential source of kilonova nebular emission observed by Spitzer

Infrared emission lines arising from transitions between fine structure levels of heavy elements are expected to produce kilonova nebular emission. For the kilonova in GW170817, strong emission at 4.5 ${\rm \mu m}$ at late times was detected by the Spitzer Space Telescope but no source was detected at 3.6 ${\rm \mu m}$. This peculiar spectrum indicates that there exist strong line emitters around 4.5 ${\rm \mu m}$ and the absence of strong lines around 3.6 ${\rm \mu m}$. To model the spectrum we prepare a line list based on the selection rules in LS coupling from the experimentally calibrated energy levels in the NIST database. This method enables to generate the synthetic spectra with accurate line wavelengths. We find that the spectrum is sensitive to the abundance pattern whether or not the first r-process peak elements are included. In both cases, the synthetic spectra can match the observed data, leading to two possible interpretations. If the first peak elements are abundant a Se III line dominates the flux. If otherwise, W III with Os III, Rh III, and Ce IV can be the main sources. Observing nebular spectra for the future kilonovae in a wider wavelength range can provide more conclusive elemental identification.Comment: 5 pages, 3 figures, submitted to MNRA

Universal validity of the second law of information thermodynamics

Feedback control and erasure protocols have often been considered as a model to embody Maxwell's Demon paradox and to study the interplay between thermodynamics and information processing. Such studies have led to the conclusion, now widely accepted in the community, that Maxwell's Demon and the second law of thermodynamics can peacefully coexist because any gain provided by the demon must be offset by the cost of performing measurement and resetting the demon's memory to its initial state. Statements of this kind are collectively referred to as second laws of information thermodynamics and have recently been extended to include quantum theoretical scenarios. However, previous studies in this direction have made several assumptions, in particular about the feedback process and the measurement performed on the demon's memory, and thus arrived at statements that are not universally applicable and whose range of validity is not clear. In this work, we fill this gap by precisely characterizing the full range of quantum feedback control and erasure protocols that are overall consistent with the second law of thermodynamics. This leads us to conclude that the second law of information thermodynamics is indeed universal: it must hold for any quantum feedback control and erasure protocol, regardless of the measurement process involved, as long as the protocol is overall compatible with thermodynamics. Our comprehensive analysis not only encompasses new scenarios but also retrieves previous ones, doing so with fewer assumptions. This simplification contributes to a clearer understanding of the theory. Additionally, our work identifies the Groenewold--Ozawa information gain as the correct information measure characterizing the work extractable by feedback control.Comment: 30 pages, 1 figure. The title is changed from the previous version and one author is added. The contents are significantly update