Stiffness and Damping of Sands in Torsion Shear

A laboratory investigation was carried out into stiffness and damping of sands as sheared in a torsional shear apparatus. In the drained monotonic and cyclic loading tests, a particular care was taken of the small strain measurements in which the secant stiffness was measured over a wide range of shear strain from about 10-6 to 10-2. Despite the marked differences in the grain size and the sample preparation method among the sands, a fairly good coincidence of the secant stiffness was seen, in common, in the range of shear strain less than about 1 x 10-5 between two types of tests using the monotonic and cyclic loadings. However, the response was softer in the monotonic loading tests for the larger strains. It has also been pointed out that the damping when examined in relation to the normalized secant shear modulus was scarcely affected by the confining pressure, and that the values of damping were smaller than those so far available in the literature

Perfluorooctane Sulfonate (PFOS) and Related Perfluorinated Compounds in Human Maternal and Cord Blood Samples: Assessment of PFOS Exposure in a Susceptible Population during Pregnancy

Fluorinated organic compounds (FOCs), such as perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorooctane sulfonylamide (PFOSA), are widely used in the manufacture of plastic, electronics, textile, and construction material in the apparel, leather, and upholstery industries. FOCs have been detected in human blood samples. Studies have indicated that FOCs may be detrimental to rodent development possibly by affecting thyroid hormone levels. In the present study, we determined the concentrations of FOCs in maternal and cord blood samples. Pregnant women 17–37 years of age were enrolled as subjects. FOCs in 15 pairs of maternal and cord blood samples were analyzed by liquid chromatography–electrospray mass spectrometry coupled with online extraction. The limits of quantification of PFOS, PFOA, and PFOSA in human plasma or serum were 0.5, 0.5, and 1.0 ng/mL, respectively. The method enables the precise determination of FOCs and can be applied to the detection of FOCs in human blood samples for monitoring human exposure. PFOS concentrations in maternal samples ranged from 4.9 to 17.6 ng/mL, whereas those in fetal samples ranged from 1.6 to 5.3 ng/mL. In contrast, PFOSA was not detected in fetal or maternal samples, whereas PFOA was detected only in maternal samples (range, < 0.5 to 2.3 ng/mL, 4 of 15). Our results revealed a high correlation between PFOS concentrations in maternal and cord blood (r(2) = 0.876). However, we did not find any significant correlations between PFOS concentration in maternal and cord blood samples and age bracket, birth weight, or levels of thyroid-stimulating hormone or free thyroxine. Our study revealed that human fetuses in Japan may be exposed to relatively high levels of FOCs. Further investigation is required to determine the postnatal effects of fetal exposure to FOCs

Gene targeting for O -methyltransferase genes, mycE and mycF , on the chromosome of Micromonospora griseorubida producing mycinamicin with a disruption cassette containing the bacteriophage φC31 attB attachment site

Mycinamicin, a 16-membered macrolide antibiotic produced by Micromonospora griseorubida , comprises a macrolactone and two deoxysugars: desosamine and mycinose. Mycinose is synthesized through two modification steps: the methylation of 6-deoxyallose in mycinamicin VI and of javose in mycinamicin III. To confirm the role of mycE and mycF genes in mycinamicin biosynthesis in M. griseorubida , disruption mutants of mycE and mycF were constructed by disruption plasmids containing attB in the disruption cassette FRT -neo-oriT- FRT -attB for the integration of φC31-derivative vector plasmids; the disruption mutants were complemented through the integration of pSET152 derivatives containing intact mycE or mycF into the artificially inserted attB site. These disruption mutants did not produce mycinamicin II, but mainly accumulated mycinamicins VI and III, indicating that MycE and MycF methylated the C2″-OH group of 6-deoxyallose in mycinamicin VI and the C3″-OH group of C2″-methylated 6-deoxyallose in mycinamicin III, respectively. The complemented strains of mycE and mycF recovered the mycinamicin II productivity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79258/1/j.1574-6968.2010.01899.x.pd

Stereoselective photodimerisation of chalcones in the molten state

Photodimerisations of chalcone and its derivatives in the molten state proceed efficiently and stereoselectively to give rac-anti-head-to-head dimers in all cases tested

The Electron Spectrum in 3C279 and the Observed Emission Spectrum

The emission mechanisms of the blazar 3C 279 are studied by solving the kinetic equations of electrons and photons in a relativistically moving blob. The gamma-ray spectral energy distribution (SED) is fitted by inverse Compton scattering of external photons. The bulk Lorentz factor of the emitting blob is found to be 25, and the magnetic field is found to be 0.3 G. GeV gamma-rays are well explained by inefficiently cooled electrons because of the Klein-Nishina effects. The electron spectrum is not a broken power law with a steeper spectrum above a break energy, which is often used to fit the observed SED. The kinetic energy density of the nonthermal electrons dominates the magnetic energy density; this result is qualitatively the same as that for TeV blazars such as Mrk 421 and Mrk 501. The gamma-ray luminosity of 3C 279 is often observed to increase rapidly. We show that one of the better sampled gamma-ray flares can be explain by the internal shock model.Comment: 9 pages, 3 figures, to be published in the Astrophysical Journal, Letter