The first light of Mini-MegaTORTORA wide-field monitoring system

Here we describe the first light of the novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-MegaTORTORA, which is being tested now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (~900 square degrees) or narrow (~100 square degrees) fields of view, either in clear light or with any combination of color (Johnson B, V or R) polarimetric filters installed, with exposure times ranging from 100 ms to 100 s. The primary goal of the system is the detection of rapid -- with sub-second characteristic time-scales -- optical transients, but it may be also used for studying the variability of the sky objects on longer time scales.Comment: 9 pages, 9 figures, based on the talk presented on "Modern stellar astronomy-2014" (Rostov-on-Don

Optical Camera with high temporal resolution to search for transients in the wide field

The wide field optical camera with high temporal resolution for the continuous monitoring of the sky in order to catch the initial stages of GRBs is described.Comment: 4 pages, 4 figures. To be published in "Il Nuovo Cimento", Proceedings of the 4th Rome Workshop on Gamma-Ray Bursts in the Afterglow Era, eds. L. Piro, L. Amati, S. Covino, B. Gendr

Accuracy comparison of several common implicit solvent models and their implementations in the context of protein-ligand binding.

In this study several commonly used implicit solvent models are compared with respect to their accuracy of estimating solvation energies of small molecules and proteins, as well as desolvation penalty in protein-ligand binding. The test set consists of 19 small proteins, 104 small molecules, and 15 protein-ligand complexes. We compared predicted hydration energies of small molecules with their experimental values; the results of the solvation and desolvation energy calculations for small molecules, proteins and protein-ligand complexes in water were also compared with Thermodynamic Integration calculations based on TIP3P water model and Amber12 force field. The following implicit solvent (water) models considered here are: PCM (Polarized Continuum Model implemented in DISOLV and MCBHSOLV programs), GB (Generalized Born method implemented in DISOLV program, S-GB, and GBNSR6 stand-alone version), COSMO (COnductor-like Screening Model implemented in the DISOLV program and the MOPAC package) and the Poisson-Boltzmann model (implemented in the APBS program). Different parameterizations of the molecules were examined: we compared MMFF94 force field, Amber12 force field and the quantum-chemical semi-empirical PM7 method implemented in the MOPAC package. For small molecules, all of the implicit solvent models tested here yield high correlation coefficients (0.87-0.93) between the calculated solvation energies and the experimental values of hydration energies. For small molecules high correlation (0.82-0.97) with the explicit solvent energies is seen as well. On the other hand, estimated protein solvation energies and protein-ligand binding desolvation energies show substantial discrepancy (up to 10kcal/mol) with the explicit solvent reference. The correlation of polar protein solvation energies and protein-ligand desolvation energies with the corresponding explicit solvent results is 0.65-0.99 and 0.76-0.96 respectively, though this difference in correlations is caused more by different parameterization and less by methods and indicates the need for further improvement of implicit solvent models parameterization. Within the same parameterization, various implicit methods give practically the same correlation with results obtained in explicit solvent model for ligands and proteins: e.g. correlation values of polar ligand solvation energies and the corresponding energies in the frame of explicit solvent were 0.953-0.966 for the APBS program, the GBNSR6 program and all models used in the DISOLV program. The DISOLV program proved to be on a par with the other used programs in the case of proteins and ligands solvation energy calculation. However, the solution of the Poisson-Boltzmann equation (APBS program) and Generalized Born method (implemented in the GBNSR6 program) proved to be the most accurate in calculating the desolvation energies of complexes

FAVOR (FAst Variability Optical Registration) -- A Two-telescope Complex for Detection and Investigation of Short Optical Transients

An astronomical complex intended to detect optical transients (OTs) in a wide field and follow them up with high time resolution investigation is described.Comment: 4 pages, 3 figures. To be published in "Il Nuovo Cimento", Proceedings of the 4th Rome Workshop on Gamma-Ray Bursts in the Afterglow Era, eds. L. Piro, L. Amati, S. Covino, B. Gendr

Effect of vasopressin on the expression of genes for key enzymes of interstitial hyaluronan turnover and concentration ability in WAG rat kidneys

In mammals, arginine-vasopressin (AVP) is a major hormone involved in the regulation of renal water reabsorption, acting via an increase in the osmotic permeability of the collecting duct epithelium. The AVP-induced intracellular events include, as an essential step, the trafficking of the vesicles containing the water channels, aquaporin-2, to the apical plasma membrane of the collecting duct principal cells. The interstitium of the renal inner medulla contains abundant linear negatively charged glycosaminoglycan hyaluronan (HA), which affects the water flow depending on their polymeric state. Using real-time RT-PCR, we tested the assumption that the renal hyaluronan may be involved in the longterm vasopressin effect on water reabsorption. The expression of the genes encoding hyaluronan synthase-2 (Has2) and hyaluronidase-1, 2 (Hyal1, Hyal2) in the kidneys of Wistar Albino Glaxo (WAG) was studied. Has2 mRNA content was the highest in the kidney papilla of the hydrated rats. The V2 receptor-selective vasopressin analog dDAVP (100 μg/kg bw, ip, twice a day for 2 days) induced a considerable decrease in Has2 mRNA content in the papilla with less pronounced changes in the cortex. In contrast to Has2, dDAVP treatment caused a significant increase in Hyal1 and Hyal2 mRNA content in the renal papilla. There was a good fit between Hyal1 and Hyal2 transcriptional level and changes in hyaluronidase activity in the renal tissue. It was suggested that vasopressin is able to inhibit the synthesis of hyaluronan and concomitantly promotes its degradation in the renal papilla interstitium, thereby facilitating water flow between elements of the renal countercurrent system. The implications for this effect are discussed in the context of the literature data

The fifth industrial revolution – innovations in the field of biotechnologies and neural networks

A comprehensive study of the phenomenon of the fifth industrial revolution is carried out. This topic is relevant due to the rapid development of biotechnologies and neural networks, transforming the environment of industries and society as a whole. Various interpretations of the term “fifth industrial revolution” are considered, and the key characteristics of previous industrial revolutions are identified and analysed. The main content of the research paper is an analysis of the scientific literature, consideration of visions of the fifth industrial revolution, as well as the identification of the main opportunities and threats that manufacturing enterprises, industries and society as a whole will face. The impact of Industry 5.0 on the economic performance of industries while meeting the needs and interests of employees, as well as ensuring environmental sustainability and resource conservation is described. The importance of the readiness of future industries to adapt to changing conditions in key value chains is emphasized. Based on the analysis of the scientific literature, the authors have revealed that the fifth industrial revolution will be determined by a new and expanded purposefulness, consisting of three basic elements: human orientation, stability and sustainability. Finally, the importance of balancing production through the development of sustainable strategic value chains, adaptable production capacities and flexible business processes was emphasized

Mini-MegaTORTORA-multichannel system for wide-field optical monitoring with high temporal resolution

We report on a multi-objective and transforming 9-channel monitoring system, the Mini-MegaTORTORA (MMT-9). This system combines a wide field of view with a subsecond temporal resolution in the monitoring regime, and is able to recofingure itself, in fractions of a second, to a follow up mode which has better sensitivity and provides us with multi-color and polarimetric information on detected transients simultaneously

Wide-field subsecond temporal resolution optical monitoring systems for the detection and study of cosmic hazards

The possibility of using multi-objective optical telescopes equipped with detectors with high time resolution is studied. Two types of instruments with six and nine channels are considered here, which include the standard high-aperture objectives with small diameters, panoramic detectors with high time resolution, and equatorial mounts. The instruments function in two regimes, the monitoring mode and the follow-up mode in which all objectives observe one field with a rapidly moving celestial object detected by monitoring. Using the FAVOR and TORTORA cameras moving satellites and meteors of 9-10 stellar magnitudes in brightness were registered. The positive experience acquired from the exploitation of the FAVOR and TORTORA systems led to awareness of the need to further develop the wide-field technique to search for fast optical transients. The main result of the realization of the project will be the construction of a new type of instrument to discover and study rapidly variable optical sources with a priori unknown location

Observations of transient events with Mini-MegaTORTORA wide-field monitoring system with sub-second temporal resolution

Here we present the summary of first years of operation and the first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-MegaTORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (900 square degrees) or narrow (100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and p olarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds. The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT also include faint meteors and artificial satellites