DETERMINING GEOMETRICAL PARAMETERS FOR A REFERENCED CRICKET BAT HANDLE

This work had been intended to set and determine the geometrical parameters for a referenced cricket bat handle for our purpose, due to geometric variations found in the handles. By reviewing related literature based on past research work carried by many researcher on cricket bat. The criterion used for selecting and determining major parameters of the handle with some new technical parameters with reference to more traditional design based on to other performance-oriented geometrical features widely employed in commercial designs of cricket bat made by the different manufacturers’ of sporting equipment in present. And so far, some new and typical geometrical parameters are considered and established for a referenced Cricket bat handle, which in turn used in a cricket bat with having a detachable handle for further study.  Article visualizations

CONSTRAINING NUMERICAL VALUES FOR A REFERENCED CRICKET BAT HANDLE ON SELECTED GEOMETRICAL PARAMETERS

A survey was carried out on Grade ‘A’ cricket bats handles, made up of the finest quality of four pieces Singapore cane with 3 rubber springs. Standard cricket bats handles were chosen from four different cricket manufacturing agencies, due to having different geometrical parameters. All handle were meticulously taken off from the blade and then they were measured and recorded, aiming to constraining a new measurement for a referenced cricket bat handle of short length. The estimation was made on the behalf of the measurement (value) taken from different size of handle ranging from their minimum to maximum, and standard values of handle keeping in view on their distinct parameters separately. So, by this way determination of geometric parameters and new modification were made for constraining measurement for a referenced cricket bat handle (i.e. short in length and round in shape) found for our purpose.  Article visualizations

Comparison of 2-octyl cyanoacrylate with prolene (4-0) sutures in extra oral wound closure

Aim: To compare the healing following various maxillofacial incisions using 2-octyl cyanoacrylate (2-OCA) and prolene (4–0) sutures. Objective: To evaluate the complications and aesthetic outcome of the incision wounds after closure using 2-OCA and prolene (4–0) sutures. Materials and Methods: The patient undergoing an extraoral incision was evaluated for pain, inflammation, infection, dehiscence, scar, and surface texture. In Group I, 15 patient incisions were closed with 2-OCA and in Group II, 15 patient incisions were closed with prolene (4–0) suture. Result: A few patients experienced pain with Group I and then Group II, but infection, inflammation, and dehiscence were more in Group I than in Group II. Conclusion: A cosmetic outcome was higher in the cyanoacrylate group, and the surface texture was satisfying in the same group

Eight versus twelve weeks of sofosbuvir-velpatasvir in treatment-naïve non-cirrhotic patients with chronic hepatitis C virus infection: Study protocol for a multicentric, open labelled, randomized, non-inferiority trial (RESOLVE trial).

BackgroundHepatitis C virus (HCV) is a common cause of liver cirrhosis and hepatocellular carcinoma. Globally, nearly 71 million people have chronic HCV infection, and approximately 399,000 dies annually. In patients without cirrhosis, HCV infection is treated with 12 weeks of sofosbuvir/velpatasvir combination. Results from available small, single-centre observational studies suggest that the sofosbuvir/velpatasvir combination given for 8 weeks may be as effective as the standard 12 weeks of treatment. We propose to compare the treatment response of 12 weeks versus 8 weeks of sofosbuvir/velpatasvir in non-cirrhotic people with chronic HCV infection.MethodsThis multicentric, randomized, open-label, non-inferiority trial will include 880 (2 arms x 440) treatment naïve, viraemic (HCV RNA >10,000 IU/mL), non-cirrhotic adults (age >18 years) with chronic hepatitis C. People who are at high-risk for HCV reinfection such as haemophiliacs, people who inject drugs, those on maintenance hemodialysis or having HIV will be excluded. The presence or absence of cirrhosis will be determined with a combination of history, examination, ultrasound, liver stiffness measured with transient elastography, APRI, FIB-4, and esophagogastroduodenoscopy. Participants will be randomized to receive either 8- or 12-week sofosbuvir/velpatasvir treatment. A blood specimen will be collected before starting the treatment (to determine the HCV genotype), after 4 weeks of treatment (for early virological response), and at 12 weeks after treatment discontinuation for SVR12.DiscussionThe study will provide data on the efficacy of 8 weeks of treatment as compared to the standard of care (12 weeks) in non-cirrhotic patients with chronic HCV infection. Treatment for a shorter duration may improve treatment compliance, reduce the cost of treatment, and ease the treatment implementation from a public health perspective.Trial registrationRegistered with Clinical Trial Registry of India (http://ctri.nic.in) Registration No. CTRI/2022/03/041368 [Registered on: 24/03/2022]-Trial Registered Prospectively

NCCP-ICS joint consensus-based clinical practice guidelines on medical thoracoscopy

Medical Thoracoscopy (MT) is commonly performed by respiratory physicians for diagnostic as well as therapeutic purposes. The aim of the study was to provide evidence-based information regarding all aspects of MT, both as a diagnostic tool and therapeutic aid for pulmonologists across India. The consensus-based guidelines were formulated based on a multistep process using a set of 31 questions. A systematic search of published randomized controlled clinical trials, open labelled studies, case reports and guidelines from electronic databases, like PubMed, EmBase and Cochrane, was performed. The modified grade system was used (1, 2, 3 or usual practice point) to classify the quality of available evidence. Then, a multitude of factors were taken into account, such as volume of evidence, applicability and practicality for implementation to the target population and then strength of recommendation was finalized. MT helps to improve diagnosis and patient management, with reduced risk of post procedure complications. Trainees should perform at least 20 medical thoracoscopy procedures. The diagnostic yield of both rigid and semirigid techniques is comparable. Sterile-graded talc is the ideal agent for chemical pleurodesis. The consensus statement will help pulmonologists to adopt best evidence-based practices during MT for diagnostic and therapeutic purposes