INDOMINABLE

INDOMINABLE, Kathleen A Fox The reformation of the feminine portrait from that of idealistic sexual beauty into a portrait of strength, community, longevity, transformation, and inane human foundational essence of societal value. This collection of portraits illustrates the uniqueness that is often overlooked for the fast, idealistic and instantly read images of women hailed as beautiful. These women contain a space they have earned with their strength of character, spirit, and unwillingness to be moved from their places of significance. Created with an expressive abstractive edge to traditional portraiture, these female portraits refuse to be easily glossed over, for their places were not easily earned and they each come with a story, a purpose, and an indomitable spirit. They are pillars known and unknown women who hold up many in ways that are important and needed but not always hailed in ways that are public or obvious. Indominable is the transitory of a colloquial definition of indomitable to give heedence to the local and significant to those closest to her

Training Community-Based Professionals to Implement an Empirically Supported Parenting Program

Professionals representing 14 community-based organizations were trained at three different sites serving urban and rural families to implement an empirically supported parenting program for families of young children with challenging behaviors. Of the 44 practitioners trained, 23 successfully completed the program, which involved passing a knowledge test and facilitating the entire 10session program with a family. A total of 28, primarily low-income families completed the program. The family outcomes obtained by the facilitators, based on multiple pre-program and post-program measures, were comparable with those reported previously in the literature for facilitators trained in university settings. The challenges inherent in efforts to increase the community’s capacity to implement empirically supported programs are addressed

Fear of Victimization Among Incarcerated Youths: Examining the Effects of Institutional “Neighborhood” Characteristics and Gang Membership

This study examines whether neighborhood factors found to predict fear of crime among the general population can be adapted to explain inmate fear of victimization inside juvenile correctional institutions. We test (a) whether institutional physical disorder, resident trust, and formal social control can predict fear of victimization, and (b) whether the importance of these factors for fear of victimization varies based on preincarceration street gang status. Using data from a large national sample of incarcerated youths, findings indicate non-gang members are more afraid of institutional victimization than gang members, confirming findings about levels of fear between these groups on the street. “Neighborhood” (institutional) physical disorder and resident trust predicted fear for gang and non-gang youths, whereas formal social control was significant only among non-gang youths. We discuss policy implications and directions for future research

Changing the Latitudes and Attitudes about Content Analysis Research

The current research employs the use of content analysis to teach research methods concepts among students enrolled in an upper-division research methods course. Students coded and analyzed Jimmy Buffett song lyrics rather than using a downloadable database or collecting survey data. Students’ knowledge of content analysis concepts increased after a lecture on the topic of content analysis, but it further improved after participating in the song coding, data cleaning, and writing of results. Additionally, students reported high satisfaction with the project and believed it was an interesting and enjoyable technique for learning about research methods. We provide suggestions for incorporating similar data collection activities in undergraduate research methods courses

Aluminum Maltolate-Induced Toxicity in NT2 Cells Occurs Through Apoptosis and Includes Cytochrome c Release

Aluminum (Al) compounds are neurotoxic and have been shown to induce experimental neurodegeneration although the mechanism of this effect is unclear. In order to study this neurotoxic effect of Al, we have developed an in vitro model system using Al maltolate and human NT2 cells. Al maltolate at 500 mM caused significant cell death with a 24-h incubation and this toxicity was even more evident after 48 h. Lower doses of Al maltolate were also effective, but required a longer incubation for cell death. Nuclear fragmentation suggestive of apoptosis was observed as early as three hours and increased substantially through 24 h. Chromatin condensation and nuclear fragmentation were confirmed by electron microscopy. In addition, TUNEL positive nuclei were also observed. The release of cytochrome c was demonstrated with Western blot analysis. This in vitro model using human cells adds to our understanding of Al neurotoxicity and could provide insight into the neurodegenerative processes in human disease

Effects of early intervention and the moderating effects of brain activity on institutionalized children's social skills at age 8

The present study examined the social skills of previously institutionalized, 8-y-old Romanian children from the Bucharest Early Intervention Project and the influence of attachment security and brain electrical activity (alpha power) on these skills. Participants included children randomized to an intervention involving foster care [Foster Care Group (FCG)], children randomized to remain in institutions [Care As Usual Group (CAUG)], and never-institutionalized children living with their families in the Bucharest community [Never-Institutionalized Group (NIG)]. A continuous rating of children's attachment security to their primary caregiver was assessed at 42 mo of age. When children were 8 y old, teachers rated their social skills, and the children's resting electroencephalogram alpha power was recorded. Teachers rated social skills of FCG children who were placed into foster care before 20 mo of age as no different from NIG children, and both of these groups were higher than CAUG children and FCG children placed after 20 mo. Electroencephalogram alpha power at age 8 significantly moderated the relations between attachment security and social skills. These findings characterize institutionalized children's social skills in middle childhood within the context of a randomized intervention while highlighting the roles of both relational and biological factors in these developmental trajectories

Peri-nuclear Clustering of Mitochondria is Triggered during Aluminum Maltolate Induced Apoptosis

Synapse loss and neuronal death are key features of Alzheimer’s disease pathology. Disrupted axonal transport of mitochondria is a potential mechanism that could contribute to both. As the major producer of ATP in the cell, transport of mitochondria to the synapse is required for synapse maintenance. However, mitochondria also play an important role in the regulation of apoptosis. Investigation of aluminum (Al) maltolate induced apoptosis in human NT2 cells led us to explore the relationship between apoptosis related changes and the disruption of mitochondrial transport. Similar to that observed with tau over expression, NT2 cells exhibit peri-nuclear clustering of mitochondria following treatment with Al maltolate. Neuritic processes largely lacked mitochondria, except in axonal swellings. Similar, but more rapid results were observed following staurosporine administration, indicating that the clustering effect was not specific to Al maltolate. Organelle clustering and transport disruption preceded apoptosis. Incubation with the caspase inhibitor zVAD-FMK effectively blocked apoptosis, however failed to prevent organelle clustering. Thus, transport disruption is associated with the initiation, but not necessarily the completion of apoptosis. These results, together with observed transport defects and apoptosis related changes in Alzheimer disease brain suggest that mitochondrial transport disruption may play a significant role in synapse loss and thus the pathogenesis or Alzheimer’s disease