A Review on <i>Annona muricata</i> and Its Anticancer Activity

The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. Medicinal plants are universally acknowledged as the cornerstone of preventative medicine and therapeutic practices. Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins. This review focuses on the role of A. muricata extract against various types of cancer, modulation of cellular proliferation and necrosis, and bioactive metabolites responsible for various pharmacological activities along with their ethnomedicinal uses. Additionally, this review highlights the molecular mechanism of the role of A. muricata extract in downregulating anti-apoptotic and several genes involved in the pro-cancer metabolic pathways and decreasing the expression of proteins involved in cell invasion and metastasis while upregulating proapoptotic genes and genes involved in the destruction of cancer cells. Therefore, the active phytochemicals identified in A. muricata have the potential to be employed as a promising anti-cancer agent

Influence of <i>Eucalyptus</i> Agroforestry on Crop Yields, Soil Properties, and System Economics in Southern Regions of India

Agroforestry benefits farmers, making it a sustainable alternative to monoculture. To create a viable Eucalyptus clone-based agroforestry system, a field experiment was carried out in Tamil Nadu, India. The economics and changes in the soil qualities were evaluated by growing agricultural and horticultural crops, namely pearl millet, sorghum, maize, sesame, small onions, green gram, and red gram, as intercrops under eight-month-old eucalyptus clone trees using a randomised block design in three replications at a spacing of 3 m × 1.5 m. The plots for the intercrops and the eucalyptus clones were kept apart for comparison. Maize showed the greatest drop in plant height during all the phases, including 30 DAS, 60 DAS, and harvest, while small onions showed the least reduction in plant height. Sesame and small onions showed the greatest drop in dry matter production, whereas sorghum showed the least. In terms of the intercrop yield reduction, maize had the biggest reduction and green gram had the lowest. Red gram had the largest crop equivalent yield, whereas maize had the lowest. The volume of the trees was generally increased more favourably by red gram than by green gram. The intercrops had some effects on the nutrients in the soil. Red gram intercropping had the highest levels of EC, soil organic carbon, available soil nitrogen, available soil phosphorus, and available soil potassium, while the sole tree treatment had the lowest levels. Small onions, red gram, and sesame were the crops; tree + small onion, tree + red gram, and tree + sesame were the intercrop combinations with the highest gross income, net income, and B:C in the intercropping treatment alone. Tree + green gram had the highest land equivalent ratio (LER) and the red gram, sesame, and small onion intercrops were shown to be the most profitable. Although the present study supports a complementary relationship, the lack of awareness among farmers of Eucalyptus allelopathy formed the major limitation